Present paper deals with the effect of Hall and ion slips on MHD blood flow through a catheterized multi-stenosis artery with thrombosis. Blood is considered a base fluid, and the suspension of Au and GO nanoparticles are used to form the hybrid nano-blood suspension. The hemodynamic mathematical model is presented to mimic the blood flow inside the artery subjected to Joule heating, thermal radiation, Hall and ion slip effects. The effect of the shape of nanoparticles and the variable viscosity depending upon hematocrit is taken into account. The mathematical model is presented in a curvilinear coordinate system, and a mild stenosis assumption is used to get the closed-form solutions. The reduced governing equations are solved using the Crank Nicholson scheme with “MATLAB.” The effect of various pertinent parameters on flow patterns are illustrated graphically. It is observed that increasing the Hall and ion slips parameter causes the increment in the fluid velocity due to an enhancement in the cyclotron frequency of the particles. The hybrid nanoparticles Au-GO/blood has a higher temperature profile than pure blood and unitary nanoparticles, as the thermal conductivity increases with an increase in nanoparticle concentration. Scientists and clinical researchers may find the present study useful in understanding the various illness’s conditions, including cancers, infections, and the removal of blood clots. Furthermore, current research may be helpful in the biomedical area, such as magnetic resonance angiography (MRA), which creates an image of an artery to identify any abnormalities in the artery. The current findings are consistent with recent findings in earlier blood flow research studies.