The flow-through various disk movement has wide range of applications in manufacturing processes like, computer storage equipment’s, rotating machines, electronic and various types of medical equipment’s. Inspired from these applications, here we scrutinised the consequences of homogeneous-heterogeneous reactions and uniform heat source/sink on the three-dimensional (3D) hybrid SWCNT-MWCNT’s flow on time dependent moving upward/downward rotating disk. The renowned innovation of this paper is the application of the hybrid nanofluid made up of SWCNT and MWCNT’s. Heat generation/absorption effect for the disk that does not move up or down creates a dual flow on the disk. Alternatively, the rotation and upright motion of the disk creates a 3D flow on the surface which has not been considered in the open literature. The modelled PDE’s are reduced in to ODE’s by opting suitable similarity variables and boundary constraints. Here, we used RKF-45 method to obtain the numerical approximations by adopting shooting technique. The analysis of rate of heat transfer is done through graphs. Further, change in velocity, thermal and concentration profiles for various non-dimensional parameters are deliberated briefly and illustrated with the help of suitable plots. The results reveal that, the, rise in values of homogeneous and heterogeneous reaction parameters improve the rate of reaction which results in reduction of the distribution rate and diminishes the concentration gradient. An increase in expansion/contraction parameter enhances the velocity and thermal gradients.