Entstehungsmechanismus von L-Asparaginase-Nebenwirkungen und deren Bekämpfung

Kodama, J; Higashino, Kazuo; Kobayashi, Shiro; Izumi, Kwanji; Satani, Makoto; Takamitsu, Yoshihiro; Yoshioka, Keiichiro; Bando, K; Kawai, Katsuyuki; Wada, Hiroshi

doi:10.1007/bf01630658

Blut

1974

DOI: 10.1007/bf01630658

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Entstehungsmechanismus von L-Asparaginase-Nebenwirkungen und deren Bekämpfung

J Kodama¹,

Kazuo Higashino²,

Shiro Kobayashi³

et al.

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1977

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Extrakorporale Asparaginasetherapie bei Allergie und toxischen Nebenwirkungen

Pralle

Löffler

1977

Blut

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L-asparaginase therapy is often limited by allergy or toxicity and probably in some cases by antibody mediated inactivation of the enzyme. These problems can be avoided by extracorporeal application of l-asparaginase. As the enzyme is a stable tetramer with high molecular weight it cannot pass through the dialysis membrane in contrast to the amino acid l-asparagin which is destroyed. The resulting l-asparagin depletion of the plasma is sufficient for therapeutic success. Effective extracorporeal l-asparaginase therapy is demonstrated in two patients with ALL who were resistant to other chemotherapy and could not be treated intravenously because of allergy and toxicity.

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Extrakorporale Asparaginasetherapie bei Allergie und toxischen Nebenwirkungen

Pralle

Löffler

1977

Blut

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Entstehungsmechanismus von L-Asparaginase-Nebenwirkungen und deren Bekämpfung

Cited by 1 publication

References 11 publications

Extrakorporale Asparaginasetherapie bei Allergie und toxischen Nebenwirkungen

Extrakorporale Asparaginasetherapie bei Allergie und toxischen Nebenwirkungen

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