Enumeration of Nucleated Red Blood Cells with the ADVIA 2120 Hematology System: An International Multicenter Clinical Trial

Kratz, Alexander; Maloum, Karim; O’Malley, Conor; Zini, Gina; Rocco, Vincenzo; Zelmanovic, David; Kling, Gail

doi:10.1532/lh96.06010

Cited by 54 publications

(52 citation statements)

References 4 publications

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“…[13,14] Because infectious conditions are associated with increased immature granulocyte levels, several investigators have examined whether this level can be used to predict the development of sepsis. [15,16] On the other hand, the serum myeloperoxidase index (MPXI) is a new index of the level of serum myeloperoxidase (MPO), which is a newly observed inflammatory marker.…”

Section: Introductionmentioning

confidence: 99%

The use of delta neutrophil index and myeloperoxidase index as diagnostic predictors of strangulated mechanical bowel obstruction in the emergency department

Sung

Lee

et al. 2016

Medicine

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Early detection of bowel strangulation is difficult in patients with mechanical bowel obstruction (MBO). There have been no previous reports of predicting strangulation in MBO cases using the delta neutrophil index (DNI), which is a measure of the proportion of circulating immature granulocytes, or the myeloperoxidase index (MPXI), which is a measure of serum myeloperoxidase level. Therefore, we evaluated differences in initial DNI and MPXI upon presentation at the emergency department (ED) according to strangulation presence in MBO patients.This is a retrospective observational study of consecutive patients older than 18 years who were diagnosed with MBO over a 31-month period. MBO was ultimately confirmed by computed tomography (CT) findings by a radiology specialist. Patients were categorized by a strangulation group (SG) and nonstrangulation group (NSG). The SG was defined by surgical and pathologic findings after the surgical operation. Initial serum counts of white blood cells and neutrophils, C-reactive protein levels, and DNI and MPXI scores were investigated in the ED.Fifteen of 160 patients were allocated to the SG (9.4%), and among the inflammatory markers, median initial DNI value was the only one that was significantly higher in the SG (0% vs 3.2%, P = 0.003). Although the areas under the receiver operation characteristic (ROC) curves for initial DNI and CT for differentiating strangulated from nonstrangulated bowel obstruction were 0.713 (95% confidence interval [CI]: 0.636–0.782) and 0.883 (95% CI: 0.823–0.928), respectively; there was no significant difference between DNI and CT (P = 0.147). The area under the curve (AUC) for predicting strangulated bowel disease from a combination of initial DNI score and CT findings (0.983, 95% CI: 0.948–0.997) was higher than the AUC for CT alone, although the difference was not significant (P = 0.052).In conclusion, initial DNI, which was performed in the ED, was found to be significantly higher in the SG than in the NSG. Initial DNI might be a useful additional parameter for improving the prediction accuracy of CT.

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Section: Introductionmentioning

confidence: 99%

The use of delta neutrophil index and myeloperoxidase index as diagnostic predictors of strangulated mechanical bowel obstruction in the emergency department

Sung

Lee

et al. 2016

Medicine

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“…DNI is calculated by an automatic counter (ADVIA 120; Siemens Healthcare Diagnostics) using myeloperoxidase (MPO) channels and nuclear lobularity channels in the test system [12]. The difference between the leukocyte differentials assayed in the two channels is designated as the DNI, which correlates with the fraction of immature granulocytes in peripheral blood calculated by manual counting.…”

Section: Introductionmentioning

confidence: 99%

Limitation of the delta neutrophil index for assessing bacteraemia in immunocompromised children

Ahn

Choi

Kim

et al. 2014

Clinica Chimica Acta

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“…[19][20][21] DNI is assessed by an automated blood cell analyzer and tests required for the DNI can be performed at the same time as routine complete blood count (CBC) test. 22 It measures the fraction of immature granulocytes in the circulation.…”

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confidence: 99%

Delta neutrophil index: A reliable marker to differentiate perforated appendicitis from non‐perforated appendicitis in the elderly

Shin

Cho

Kim

et al. 2017

Clinical Laboratory Analysis

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Background Delta neutrophil index (DNI) is a new inflammatory marker and the present study aimed to evaluate the predictive value of the DNI for the presence of a perforation in elderly with acute appendicitis. Methods This retrospective observational study was conducted on 108 consecutive elderly patients (≥65 years old) with acute appendicitis treated over a 24‐month period. Results Sixty‐nine of the 108 patients (median, IQR: 72, 67‐77 years) were allocated to the perforated appendicitis group (63.9%) and 39 to the non‐perforated appendicitis group (36.1%). WBC, neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio and DNI were significantly higher in the perforated group. In multiple logistic regression analyses, initial DNI was the only independent marker that can significantly predict the presence of perforation in multiple regression [odds ratio 9.38, 95% confidence interval (2.51‐35.00), P=.001]. Receiver operator characteristic curve analysis showed that DNI is a good predictor for the presence of appendiceal perforation at an optimal cut‐off for DNI being 1.4% (sensitivity 67.7%, specificity 90.0%, AUC 0.807). Conclusion Clinicians can reliably differentiate acute perforated appendicitis from non‐perforated appendicitis by DNI level of 1.4 or more in elderly patients.

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Enumeration of Nucleated Red Blood Cells with the ADVIA 2120 Hematology System: An International Multicenter Clinical Trial

Cited by 54 publications

References 4 publications

The use of delta neutrophil index and myeloperoxidase index as diagnostic predictors of strangulated mechanical bowel obstruction in the emergency department

The use of delta neutrophil index and myeloperoxidase index as diagnostic predictors of strangulated mechanical bowel obstruction in the emergency department

Limitation of the delta neutrophil index for assessing bacteraemia in immunocompromised children

Delta neutrophil index: A reliable marker to differentiate perforated appendicitis from non‐perforated appendicitis in the elderly

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