Envelope and spectral frequency-following responses to vowel sounds

Aiken, Steven J.; Picton, Terence W.

doi:10.1016/j.heares.2008.08.004

Cited by 334 publications

(357 citation statements)

References 61 publications

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“…This finding is consistent with previous research showing that the inferior colliculus phase-locks to the envelope and frequency of amplitude modulation of sound (Hall, 1979;Cariani and Delgutte, 1996;Joris et al, 2004;Aiken and Picton, 2008). When we compared musicians and nonmusicians, we found that musicians showed more accurate representation of the envelope periodicity of the stimulus than nonmusicians.…”

Section: Combination Tones In the Brainstemsupporting

confidence: 93%

“…In this study, we used F R s of 1.6 (166 Hz/99 Hz) and 1.7 (166 Hz/93 Hz), and very few studies have demonstrated cochlear distortion products with such wide F R s (Knight and Kemp, 1999, 2001Dhar et al, 2005). Another possibility is that 2f 1 Ϫ f 2 in the FFR reflects the amplitude modulation frequency of the 2f 1 and f 2 components of the stimulus, given that inferior colliculus neurons readily respond to the frequency of the amplitude modulation (Hall, 1979;Cariani and Delgutte, 1996;Joris et al, 2004;Aiken and Picton, 2008). The spectrograms of the stimuli show an obvious amplitude modulation between 2f 1 and f 2 (Fig.…”

Section: Combination Tones In the Brainstemmentioning

confidence: 99%

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Selective Subcortical Enhancement of Musical Intervals in Musicians

Skoe²,

et al. 2009

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By measuring the auditory brainstem response to two musical intervals, the major sixth (E3 and G2) and the minor seventh (E3 and F#2), we found that musicians have a more specialized sensory system for processing behaviorally relevant aspects of sound. Musicians had heightened responses to the harmonics of the upper tone (E), as well as certain combination tones (sum tones) generated by nonlinear processing in the auditory system. In music, the upper note is typically carried by the upper voice, and the enhancement of the upper tone likely reflects musicians' extensive experience attending to the upper voice. Neural phase locking to the temporal periodicity of the amplitude-modulated envelope, which underlies the perception of musical harmony, was also more precise in musicians than nonmusicians. Neural enhancements were strongly correlated with years of musical training, and our findings, therefore, underscore the role that long-term experience with music plays in shaping auditory sensory encoding.

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Section: Combination Tones In the Brainstemsupporting

confidence: 93%

Section: Combination Tones In the Brainstemmentioning

confidence: 99%

Selective Subcortical Enhancement of Musical Intervals in Musicians

Skoe²,

et al. 2009

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“…Wave amplitudes measured from ABRs also provide insight into the representation of phasic information to short stimuli, based on clearly defined peaks that have been mapped onto specific generators in the auditory brainstem and midbrain (Lev and Sohmer 1972;Rowe 1981;Chen and Chen 1991). Frequency-following responses (FFRs) to tonal carriers or to the modulation envelope (envelopefollowing responses or EFRs), though still not widely used in the clinic, are rapidly gaining prominence as a means of assessing processing of complex sounds from the auditory pathway (Cunningham et al 2001;Aiken and Picton 2008;Swaminathan et al 2008;Basu et al 2010;Clinard et al 2010;Krishnan et al 2010;Parbery-Clark et al 2011;Anderson et al 2012). FFRs and EFRs are evoked in response to longer, often more spectro-temporally complex stimuli (Krishnan 1999(Krishnan , 2002Krishnan et al 2004;Swaminathan et al 2008), and are strongly influenced by rostral brainstem and midbrain generators (Kiren et al 1994;Kuwada et al 2002;Akhoun et al 2010;Chandrasekaran and Kraus 2010;Parthasarathy and Bartlett 2012).…”

Section: Introductionmentioning

confidence: 99%

Age-Related Changes in the Relationship Between Auditory Brainstem Responses and Envelope-Following Responses

Parthasarathy

Datta

Torres

et al. 2014

JARO

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Hearing thresholds and wave amplitudes measured using auditory brainstem responses (ABRs) to brief sounds are the predominantly used clinical measures to objectively assess auditory function. However, frequency-following responses (FFRs) to tonal carriers and to the modulation envelope (envelope-following responses or EFRs) to longer and spectro-temporally modulated stimuli are rapidly gaining prominence as a measure of complex sound processing in the brainstem and midbrain. In spite of numerous studies reporting changes in hearing thresholds, ABR wave amplitudes, and the FFRs and EFRs under neurodegenerative conditions, including aging, the relationships between these metrics are not clearly understood. In this study, the relationships between ABR thresholds, ABR wave amplitudes, and EFRs are explored in a rodent model of aging. ABRs to broadband click stimuli and EFRs to sinusoidally amplitude-modulated noise carriers were measured in young (3-6 months) and aged (22-25 months) Fischer-344 rats. ABR thresholds and amplitudes of the different waves as well as phase-locking amplitudes of EFRs were calculated. Age-related differences were observed in all these measures, primarily as increases in ABR thresholds and decreases in ABR wave amplitudes and EFR phaselocking capacity. There were no observed correlations between the ABR thresholds and the ABR wave amplitudes. Significant correlations between the EFR amplitudes and ABR wave amplitudes were observed across a range of modulation frequencies in the young. However, no such significant correlations were found in the aged. The aged click ABR amplitudes were found to be lower than would be predicted using a linear regression model of the young, suggesting altered gain mechanisms in the relationship between ABRs and FFRs with age. These results suggest that ABR thresholds, ABR wave amplitudes, and EFRs measure complementary aspects of overlapping neurophysiological processes and the relationships between these measurements changes asymmetrically with age. Hence, measuring all three metrics provides a more complete assessment of auditory function, especially under pathological conditions like aging.

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“…Responses to stimuli of alternating polarities were averaged together to minimize stimulus artifacts and cochlear microphonic, preserving the FFR to the stimulus envelope (Aiken and Picton, 2008). In the FFR to the Participants were presented with the consonant-vowel syllable /ba/ with a duration of 170 ms.…”

Section: Data Processing and Analysesmentioning

confidence: 99%

Involvement of the Serotonin Transporter Gene in Accurate Subcortical Speech Encoding

et al. 2016

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A flourishing line of evidence has highlighted the encoding of speech sounds in the subcortical auditory system as being shaped by acoustic, linguistic, and musical experience and training. And while the heritability of auditory speech as well as nonspeech processing has been suggested, the genetic determinants of subcortical speech processing have not yet been uncovered. Here, we postulated that the serotonin transporter-linked polymorphic region (5-HTTLPR), a common functional polymorphism located in the promoter region of the serotonin transporter gene (SLC6A4), is implicated in speech encoding in the human subcortical auditory pathway. Serotonin has been shown as essential for modulating the brain response to sound both cortically and subcortically, yet the genetic factors regulating this modulation regarding speech sounds have not been disclosed. We recorded the frequency following response, a biomarker of the neural tracking of speech sounds in the subcortical auditory pathway, and cortical evoked potentials in 58 participants elicited to the syllable /ba/, which was presented Ͼ2000 times. Participants with low serotonin transporter expression had higher signal-to-noise ratios as well as a higher pitch strength representation of the periodic part of the syllable than participants with medium to high expression, possibly by tuning synaptic activity to the stimulus features and hence a more efficient suppression of noise. These results imply the 5-HTTLPR in subcortical auditory speech encoding and add an important, genetically determined layer to the factors shaping the human subcortical response to speech sounds.

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Envelope and spectral frequency-following responses to vowel sounds

Cited by 334 publications

References 61 publications

Selective Subcortical Enhancement of Musical Intervals in Musicians

Selective Subcortical Enhancement of Musical Intervals in Musicians

Age-Related Changes in the Relationship Between Auditory Brainstem Responses and Envelope-Following Responses

Involvement of the Serotonin Transporter Gene in Accurate Subcortical Speech Encoding

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