Environment‐Sensitive Two‐Photon Probe for Intracellular Free Magnesium Ions in Live Tissue

Kim, Hwan Myung; Jung, Cheol Woong; Kim, Bo Ra; Jung, Soonyoung; Hong, Jin Hee; Ko, Young‐Gyu; Lee, Kyoung J.; Cho, Bong Rae

doi:10.1002/ange.200700169

Cited by 36 publications

(26 citation statements)

References 21 publications

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“…After this, troublesome formation of amides 8 a (31 % yield) and 8 b (35 % yield) was achieved by reaction between amines 7 a and 7 b and 3-(naphthalen-1-ylamino) propanoic acid, using 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDCI) as a coupling agent. [23] Compounds 1 and 2 were finally obtained by reaction between naphthylamines 8 a and 8 b and N-ethyl-5-hydroxy-2-methyl-4-nitrosobenzenaminium chloride in methanol, under acidic catalyst and heated at reflux (45 and 35 % yield for 1 and 2, respectively). [24] Importantly, this last step did not only allow the benzophenoxazine dye group of both fluorescent guests to be constructed, but also concomitant cleavage of the methoxymethylethers to eventually obtain compound 1.…”

Section: Full Papermentioning

confidence: 99%

Encapsulation and Release Mechanisms in Coordination Polymer Nanoparticles

Amorín-Ferré

Busquè

Bourdelande

et al. 2013

Chemistry A European J

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The interplay of guest encapsulation and release mechanisms in nanoscale metal–organic vehicles and its effect on the drug‐delivery kinetics of these materials were investigated through a new multidisciplinary approach. Two rationally‐designed molecular guests were synthesized, which consist of a red‐fluorescent benzophenoxazine dye covalently tethered to a coordinating catechol group and a protected, non‐coordinating catechol moiety. This allowed loading of the guests into compositionally and structurally equivalent coordination polymer particles through distinct encapsulation mechanisms: coordination and mechanical entrapment. The two types of particles delivered their fluorescent cargo with remarkably different kinetic profiles, which could be satisfactorily modeled considering degradation‐ and diffusion‐controlled release processes. This demonstrates that careful selection of the method of guest incorporation into coordination polymer nanoparticles allows selective tuning of the rate of drug delivery from these materials and, therefore, of the time window of action of the encapsulated therapeutic agents.

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Section: Full Papermentioning

confidence: 99%

Encapsulation and Release Mechanisms in Coordination Polymer Nanoparticles

Amorín-Ferré

Busquè

Bourdelande

et al. 2013

Chemistry A European J

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“…Moreover, most of the output signals of the fluoride sensors are limited to the change of single-photon-related absorption or emission properties, although in the past 20 years many twophoton chemosensors have also been greatly developed to image the distribution of ions in cellular processes with deeper penetration and higher 3D spatial selectivity than that the single-photon technique can attain [28][29][30][31][32][33]. Following our preliminary work of exploring novel two-photon-excited fluorescent (TPEF) chemosen- All the measurement were carried out with C = 10 M. a 1 GM = 10 −50 cm 4 s −1 photon −1 molecule −1 , the wavelength of the input laser is 800 nm.…”

Section: Introductionmentioning

confidence: 99%

A trivalent organoboron compound as one and two-photon fluorescent chemosensor for fluoride anion

Cao

Liu

2008

Sensors and Actuators B: Chemical

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“…Many algorithms exist for solving partial differential equations (PDEs) for light beam propagation, including the Runge-Kutta method, beam propagation method, finite difference time domain, split-step method, finite element method and Crank-Nicholson method to name a few that have been used in photonics [1][2][3][4][5][6][7][8][9][10][11][12][13] . Most of these involve a description of the wave nature of the electromagnetic field.…”

Section: Introductionmentioning

confidence: 99%

Graphical computational method for active materials in simulation of optical electromagnetics

2014

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Traditional numerical analyses of laser beam transmission through "active" nonlinear materials have involved many assumptions that narrow their general applicability. As more complex optical phenomena are widely employed in research and industry, it is necessary to expand the use of numerical simulation methods. Historically, laser-matter interactions have involved calculations of "classical" wave propagation by Maxwell's equations and photon absorption through rate equations using numerous approximations.We describe a novel numerical modeling framework that adapts itself for simulation of different types of active materials provided by a simple graphical input. Our framework combines classical electric field propagation with "active" photon absorption kinetics using computational active photonic building blocks (APBB). It allows investigating a plane electromagnetic wave propagating through generic organic or inorganic photoactive materials; while, "active" photo-transitions are implemented using the APBB algorithm on the user interface.To date we have used the method in multiphoton absorbers, upconversion, semiconductor quantum dots, rare earth ions, organic chromophores, singlet oxygen formation, energy transfer, and optically-induced chemical reactions. We will demonstrate the method with applications of amplification in rare-earth ions and multiple two-photon absorbers materials in tandem.

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Environment‐Sensitive Two‐Photon Probe for Intracellular Free Magnesium Ions in Live Tissue

Cited by 36 publications

References 21 publications

Encapsulation and Release Mechanisms in Coordination Polymer Nanoparticles

Encapsulation and Release Mechanisms in Coordination Polymer Nanoparticles

A trivalent organoboron compound as one and two-photon fluorescent chemosensor for fluoride anion

Graphical computational method for active materials in simulation of optical electromagnetics

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