Environmental and biological influences on the stability of silver nanoparticles

Liu, Wei; Zhou, Qunfang; Liu, Jiyan; Fu, Jianjie; Liu, Sijin; Jiang, Guibin

doi:10.1007/s11434-010-4332-8

Cited by 28 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once AgNPs aggregate, a significant loss of antibacterial activity occurs due to their inability to penetrate the plasma membrane and loss of surface area (High School Nanoscience Program). Consequently, the decreased stability of AgNPs may lead to loss of their nanoscale properties [26] . Further, aggregation of AgNPs decreased their effect and cellular uptake and modifies their bioavailability and toxicity [27] .…”

Section: Discussionmentioning

confidence: 99%

Histological and immunohistochemical study on the potential toxicity of sliver nanoparticles on the structure of the spleen in adult male albino rats

Mazen

Saleh

Mahmoud

et al. 2017

Egyptian Journal of Histology

View full text Add to dashboard Cite

Introduction: Silver nanoparticles (AgNPs) remain one of the controversial research areas regarding their distribution, dissolution and their toxicity to biological systems. Aim of the work: To evaluate the potential toxicity of different doses of AgNPs on the spleen of adult Albino rats. Materials and Methods: Forty adult male albino rats were divided into two main groups; control group: included ten rats that received intraperitoneal saline solution, daily, and experimental group: included thirty rats that received intraperitoneal AgNPs dissolved in saline solution, and were equally subdivided into three subgroups. Subgroup IIa received AgNPs (100 mg/ kg/d), subgroup IIb received AgNPs (500 mg/kg/d) and subgroup IIc received AgNPs (1000 mg/kg/d). After 28 days, rats were euthanized and the spleen specimens were prepared for light and electron microscope studies. Results: Spleen of AgNPs-treated rats revealed dose-dependent structural changes in the form of reduced sized white pulp follicles with depletion of lymphocytes, degeneration and apoptosis. Nanoparticles were seen in both white and red pulps. There was a highly statistical significant increase in the optical density of caspase-3 in subgroups IIa, IIb and IIc when compared to that of the control group. Conclusions: AgNPs induced structural alterations in the spleen with evidence of inflammatory response and oxidative stress. These effects were dose-dependent.

show abstract

Section: Discussionmentioning

confidence: 99%

Histological and immunohistochemical study on the potential toxicity of sliver nanoparticles on the structure of the spleen in adult male albino rats

Mazen

Saleh

Mahmoud

et al. 2017

Egyptian Journal of Histology

View full text Add to dashboard Cite

show abstract

“…Like other nanoparticles, the particles' tendency to agglomerate is one of the major obstacles of silver nanoparticle formation. Furthermore, in the biological experimental aspect of the silver nanoparticles, the agglomeration of the AgNPs in biological media such as DMEM tends to increase, making it difficult to accurately study the concentration dependent effects of the AgNPs [28]. Thus, it is important to select a ligand that is physically suitable in preventing the agglomeration of the silver ions at the nano-level by acting as a stabilizing agent.…”

Section: That Agmentioning

confidence: 99%

Investigating the versatility of multifunctional silver nanoparticles: preparation and inspection of their potential as wound treatment agents

et al. 2015

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) are capable of inhibiting the growth of a broad spectrum of bacterial species. The minute size of the nanoparticulates enhances their biocidal activity and is thus widely utilized as antibacterial agents. The most recently researched and recognized antibacterial and wound-healing properties of published AgNPs were investigated in this article. The following parameters of the AgNPs affecting their properties and potency were explored: particle size, shape, and type of ligand or stabilizing agent. Research regarding the antibacterial activity enhancement of high-valent silver nanoparticles compared to those of the lower valent forms were summarized and analyzed. Nanocrystalline silver is capable of binding to components that may enhance their preparation and antibacterial properties. By forming complexes with ligands that exhibit desired properties, silver nanoparticles can be synthesized to exhibit those desired properties without compromising their performance. This review will provide a detailed discussion regarding the parameter-dependent bactericidal properties of silver nanoparticles and nanocomposite silver complexes as potent multifunctional wound-healing agents. Graphical AbstractKeywords Silver nanoparticles Á High-valence silver Á Antibacterial Á Wound healing Á Cell proliferation Abbreviations AgNPsSilver nanoparticles ADP Adenosine diphosphate ATP Adenosine triphosphate SEM Scanning electron microscopy AFM Atomic force microscopy DLS Dynamic light scattering TEM Transmission electron microscopy XPS X-ray photoelectron spectroscopy XRD Powder X-ray diffraction

show abstract

“…In these studies, it has been reported that the effect of nanoparticles on cells largely depends on the cell type and the characterization of AgNPs, including size, shape, surface charge and coating, dispersity and disperse medium, mode of entry, and exposure time and concentration. 7 The type of nanoparticles entering the cell is also determined based on these properties, which can include diffusion, transmembrane channels, or adhesive interactions. 7 Despite the huge benefits of AgNPs, these contributing factors sometimes cause unfavorably toxicity with culture media or other cellular biomolecules.…”

Section: Introductionmentioning

confidence: 99%

“…7 The type of nanoparticles entering the cell is also determined based on these properties, which can include diffusion, transmembrane channels, or adhesive interactions. 7 Despite the huge benefits of AgNPs, these contributing factors sometimes cause unfavorably toxicity with culture media or other cellular biomolecules. Based on these findings, understanding the mechanisms involved in the effectiveness of these nanoparticles are still unclear and more importantly, there is a great deal of uncertainty about their usage feasibility as a drug or drug delivery agent.…”

Section: Introductionmentioning

confidence: 99%

The possible effect of silver nanoparticles on glyceraldehyde‐3‐phosphate dehydrogenase activity and formation of amyloid‐like aggregates in MCF‐7 cell line

et al. 2020

View full text Add to dashboard Cite

Silver nanoparticles (AgNPs) are widely used in medicine, however, the underlying mechanisms of their action on cellular signaling have not been completely determined, and fundamental studies are required to clarify them. We aimed to investigate AgNPs effects on glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) as both the internal control gene and the redox‐sensitive enzyme involved in apoptosis‐related pathways and the formation of amyloid aggregates. To achieve this purpose, MCF‐7 cells were treated with different concentrations (0, 3, 22, and 200 μg/ml) of AgNPs and then cell viability, generation of reactive oxygen species (ROS), induction of apoptosis, expression of GAPDH gene, the formation of amyloid aggregates, and GAPDH activity were assessed. The results indicated that treatment with AgNPs significantly reduced cell viability and increased apoptosis in a dose‐dependent manner. The ROS levels increased at lower concentrations of AgNPs (up to 22 μg/ml) and during short‐term exposure (30 min). The level of GAPDH gene expression was significantly upregulated by 1.22, 1.47, and 1.56 fold, in the concentrations of 3, 22, and 200 μg/ml, respectively. The amount of amyloid aggregates was significantly increased in a dose‐dependent manner. The results of enzyme activity showed that AgNPs were affected on the activity of GAPDH protein, however, it has fluctuated that could not be interpreted by our limited data. In conclusion, our results suggested that AgNPs could affect the GAPDH gene expression and enzyme activity, therefore the selection of GAPDH as a gene and protein internal control in the (AgNPs)‐related studies requires careful consideration. Additionally, AgNPs may cause apoptosis due to the increase in the production of amyloid aggregates.

show abstract

Environmental and biological influences on the stability of silver nanoparticles

Cited by 28 publications

References 26 publications

Histological and immunohistochemical study on the potential toxicity of sliver nanoparticles on the structure of the spleen in adult male albino rats

Histological and immunohistochemical study on the potential toxicity of sliver nanoparticles on the structure of the spleen in adult male albino rats

Investigating the versatility of multifunctional silver nanoparticles: preparation and inspection of their potential as wound treatment agents

The possible effect of silver nanoparticles on glyceraldehyde‐3‐phosphate dehydrogenase activity and formation of amyloid‐like aggregates in MCF‐7 cell line

Contact Info

Product

Resources

About