International audienceIn this study, a continuous process combining plasma and photocatalysis, at pilot scale, has been investigated on pollution treatment. The degradation efficiency and by-products formation has been monitored through the variation of multiple parameters such as inlet concentration, specific energy, and residence time. Results show that process combination leads to an enhancement of pollutant degradation compared to the separate systems even at high flow rate (250 m(3) h(-1)). Synergy factor due to this association ranged from 1.10 to 1.17. Furthermore, CO2 selectivity has significantly improved when comparing the combined system to that with plasma alone. Moreover, we note that adding a photocatalyst in the discharge zone leads to a reduction of ozone and CO formation compared to plasma process alone. Based on this investigation, a methodology of scaling up the combined system was proposed. Indeed, as a practical application, an industrial reactor has been developed and tested for treating a real pollution from animal quartering centers. This investigation indicates that the combined system of photocatalysis with plasma is a promising method for removing air pollutants