Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans

Zheng, Xuehan; Zhang, Kun; Zhao, Yanbin; Fent, Karl

doi:10.1016/j.envint.2020.106159

Cited by 59 publications

(36 citation statements)

References 169 publications

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“…We further analysed the data to determine changes in a circadian rhythm by autocorrelation analysis using MATLAB. Circadian rhythms are a fundamental behavioural trait and an essential factor governing organisms’ physiology and behavioural activities (Melvin 2017 ; Zheng et al 2021 ). Circadian rhythms have an essential role in sleep cycles, hormone secretion, blood pressure, and other routine life processes.…”

Section: Discussionmentioning

confidence: 99%

“…Circadian rhythms regulate immune processes in an organism (Ren et al 2018 ), which can be adjusted due to chemical-mediated changes in internal homeostasis towards adaptation (Yang et al 2018 ). Cellular free radicals and the circadian clock are interconnected; thus, alterations in antioxidants’ defence mechanisms result in fish circadian disruption (Zheng et al 2021 ). NaOCl has the potential to cross-link fibrinogen and affect blood plasma antioxidants defence mechanisms (immunostimulatory properties) (Manucat-Tan et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of eco-toxic effects of commonly used water disinfectant on zebrafish (Danio rerio) swimming behaviour and recovery responses: an early-warning biomarker approach

Ren

Ramesh

et al. 2022

Environ Sci Pollut Res

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Eco-toxicity profiles for commonly used disinfectants were lacking. Available traditional toxicity techniques have some limitations (assessments and ethical issues). Behaviour toxicology is a promising research area towards early warning and non-invasive approaches. We studied the potential eco-toxic effects of sodium hypochlorite (NaOCl) on the swimming behaviour of zebrafish. Zebrafish were exposed to different concentrations (Treatment I, Treatment II, Treatment III, and Treatment IV) of NaOCl for 360 h. Recovery study (144 h) was conducted for NaOCl treatment groups. The swimming behaviour of zebrafish was quantified efficiently using an online monitoring system (OMS). OMS dataset was processed for determination of behavioural differences by MATLAB and SPSS. Compared to the control group, the swimming strength of zebrafish under NaOCl treatments declined significantly ( p < 0.001). Avoidance behaviour has occurred on zebrafish under NaOCl exposure periods. Furthermore, NaOCl toxicity also adjusted circadian rhythms on zebrafish. Zebrafish swimming strength was significantly ( p < 0.001) improved under-recovery periods. Moreover, normal diurnal patterns have occurred. NaOCl could cause behavioural abnormalities in non-target organisms. Continuous exposure to common disinfectants could cause external and internal stress on non-target organisms, resulting in behavioural changes and circadian rhythm adjustments. Continuous changes in behavioural and circadian rhythms might reduce organisms’ fitness and adaptation capacity. This study highlights (1) the importance of computer-based toxicity assessments, and (2) swimming behaviour is an early warning biomarker for eco-toxicity studies. Graphic Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11356-021-18333-1.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of eco-toxic effects of commonly used water disinfectant on zebrafish (Danio rerio) swimming behaviour and recovery responses: an early-warning biomarker approach

Ren

Ramesh

et al. 2022

Environ Sci Pollut Res

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“… 59 In the literature, numerous studies show how prolonged exposure to BPA affects the homeostasis of this system. 60 Levels of circulating sex steroid hormones are responsible to the modulation of circadian rhythms and particularly of circadian locomotor rhythms and estrus phase is associated with higher locomotor activity in rodents. 61 Therefore, the persistence of estrus could be responsible of the higher distance traveled by our BPAtreated mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)

et al. 2021

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Bisphenol A (BPA), an organic synthetic compound found in some plastics and epoxy resins, is classified as an endocrine disrupting chemical. Exposure to BPA is especially dangerous if it occurs during specific “critical periods” of life, when organisms are more sensitive to hormonal changes (i.e., intrauterine, perinatal, juvenile or puberty periods). In this study, we focused on the effects of chronic exposure to BPA in adult female mice starting during pregnancy. Three months old C57BL/6J females were orally exposed to BPA or to vehicle (corn oil). The treatment (4 µg/kg body weight/day) started the day 0 of pregnancy and continued throughout pregnancy, lactation, and lasted for a total of 20 weeks. BPA-treated dams did not show differences in body weight or food intake, but they showed an altered estrous cycle compared to the controls. In order to evidence alterations in social and sociosexual behaviors, we performed the Three-Chamber test for sociability, and analyzed two hypothalamic circuits (well-known targets of endocrine disruption) particularly involved in the control of social behavior: the vasopressin and the oxytocin systems. The test revealed some alterations in the displaying of social behavior: BPA-treated dams have higher locomotor activity compared to the control dams, probably a signal of high level of anxiety. In addition, BPA-treated dams spent more time interacting with no-tester females than with no-tester males. In brain sections, we observed a decrease of vasopressin immunoreactivity (only in the paraventricular and suprachiasmatic nuclei) of BPA-treated females, while we did not find any alteration of the oxytocin system. In parallel, we have also observed, in the same hypothalamic nuclei, a significant reduction of the membrane estrogen receptor GPER1 expression.

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“…Insects have a tremendous impact on ecosystems and the economy. However, research on the daily (and circadian) control of xenobiotic metabolism in insects, including insecticides, is still scarce in comparison to studies done on vertebrates [ 38 , 39 , 40 , 41 , 42 , 43 ]. Fortunately, in recent years, the current data has been successively supplemented with new reports [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Oscillator Affects Susceptibility of Caterpillars to Insecticides: Studies on the Egyptian Cotton Leaf Worm—Spodoptera littoralis (Lepidoptera: Noctuidae)

Darwich

Chrzanowski

Bernatowicz

et al. 2022

Insects

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The molecular oscillator is the core of the biological clock and is formed by genes and proteins whose cyclic expression is regulated in the transcriptional-translational feedback loops (TTFLs). Proteins of the TTFLs are regulators of both their own and executive genes involved in the control of many processes in insects (e.g., rhythmic metabolism of xenobiotics, including insecticides). We disrupted the clock operation in S. littoralis larvae by injecting the dsRNA of clock genes into their body cavity and culturing the larvae under continuous light. As a result, the daily susceptibility of larvae to insecticides was abolished and the susceptibility itself increased (in most cases). In the fat body, midgut, and Malpighian tubules (the main organs metabolizing xenobiotics) of the larvae treated with injected-dsRNA, the daily activity profiles of enzymes involved in detoxification—cytochrome P450 monooxygenases, Glutathione-S-transferase, and esterase—have changed significantly. The presented results prove the role of the molecular oscillator in the regulation of larvae responses to insecticides and provide grounds for rational use of these compounds (at suitable times of the day), and may indicate clock genes as potential targets of molecular manipulation to produce plant protection compounds based on the RNAi method.

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Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans

Cited by 59 publications

References 169 publications

Assessment of eco-toxic effects of commonly used water disinfectant on zebrafish (Danio rerio) swimming behaviour and recovery responses: an early-warning biomarker approach

Assessment of eco-toxic effects of commonly used water disinfectant on zebrafish (Danio rerio) swimming behaviour and recovery responses: an early-warning biomarker approach

Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)

Molecular Oscillator Affects Susceptibility of Caterpillars to Insecticides: Studies on the Egyptian Cotton Leaf Worm—Spodoptera littoralis (Lepidoptera: Noctuidae)

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