Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism

Lea, Richard G.; Byers, Andrew; Sumner, Rebecca; Rhind, S. M.; Zhang, Zulin; Freeman, Sarah; Moxon, Rachel; Richardson, Holly M.; Green, Martin J.; Craigon, J.

doi:10.1038/srep31281

Cited by 40 publications

(71 citation statements)

References 61 publications

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“…In conclusion, from the major differences observed between breeds in sperm kinematic traits, which confirm the diversity in other sperm traits already described, it may be advisable to refrain from a generalization for dogs when carrying out reproductive studies in this species (Hewitt, Leahy, Sheldon, & England, ; Peña, Barrio, Quintela, & Herradón, ; Sánchez‐Calabuig et al, ). On the other hand, dog breeds could constitute a very useful model to examine a diversity of responses in reproductive studies, including the effect of environmental contaminants on sperm traits (Lea et al, ) and also for understanding the different aspects of female reproductive biology that may influence the evolution of sperm traits, as carried out in other taxa focusing on intra‐ and interspecific comparisons (Anderson et al, ; Roldan et al, ; Soler, García et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, dog breeds could constitute a very useful model to examine a diversity of responses in reproductive studies, including the effect of environmental contaminants on sperm traits (Lea et al, 2016) and also for understanding the different aspects of female reproductive biology that may influence the evolution of sperm traits, as carried out in other taxa focusing on intra-and interspecific | 801 VALVERDE Et AL.…”

Section: Discussionmentioning

confidence: 99%

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Dog sperm swimming parameters analysed by computer‐assisted semen analysis of motility reveal major breed differences

Valverde

Arnau

García‐Molina

et al. 2019

Reprod Domestic Animals

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Contents Dogs have undergone an intensive artificial selection process ever since the beginning of their relationship with humans. As a consequence, a wide variety of well‐defined breeds exist today. Due to the enormous variation in dog phenotypes and the unlikely chance of gene exchange between them, the question arises as to whether they should still be regarded as a single species or, perhaps, they be considered as different taxa that possess different reproductive traits. The aim of this study was therefore to characterize some male reproductive traits, focusing on kinematic characteristics of dog spermatozoa from several breeds. Thirty‐seven dogs from the following breeds were used: Staffordshire Bull Terrier, Labrador Retriever, Spanish Mastiff, Valencian Rat Hunting Dog, British Bulldog and Chihuahua. Semen samples were obtained via manual stimulation and diluted to a final sperm concentration of 50 million/ml, and they were subsequently analysed by the computer assisted semen analysis (CASA‐Mot) ISAS®v1 system. Eight kinematic parameters were evaluated automatically. All parameters showed significant different values among breeds and among individuals within each breed. The fastest sperm cells were those of Staffordshire Bull Terriers and the slowest were recorded in Chihuahuas. The intra‐male coefficient of variation (CV) was higher than the inter‐male CV for all breeds with the Staffordshire Bull Terrier showing the lowest values. When taking into consideration the cells by animal and breed, discriminant analyses showed a high capability to predict the breed. Cluster analyses showed a hierarchical classification very close to that obtained after phylogenetic studies with genome markers. In conclusion, future workers on dog spermatozoa should bear in mind major differences between breeds and realize that results cannot be extrapolated from one to another. Because sperm characteristics are associated with breed diversity, dogs may represent a good model to examine changes in reproductive parameters associated with selection processes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dog sperm swimming parameters analysed by computer‐assisted semen analysis of motility reveal major breed differences

Valverde

Arnau

García‐Molina

et al. 2019

Reprod Domestic Animals

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“…Further understanding of breed priorities according to the brachycephalic index would allow targeted implementation of breed standards and criteria. While comparative data on conception and prevalence of caesarean sections is lacking across all dog breeds, a recent study highlighted a general reduction in the fertility of male dogs [35]. In a retrospective cohort study of Norwegian purebred dogs, 8% of pups died before eight days of age, in 10,810 litters and 224 breeds [36].…”

Section: Discussionmentioning

confidence: 99%

Selection of Breeding Stock among Australian Purebred Dog Breeders, with Particular Emphasis on the Dam

Czerwinski

McArthur

Smith

et al. 2016

Animals

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Simple SummaryOne of the most important factors influencing the health and welfare of puppies is the decision made by the breeder on which dam and sire they will breed from. Unfortunately, our understanding of what dog breeders consider important when selecting their dogs, particularly the dam, is limited. In order to bridge this gap, we conducted an online survey of Australian purebred dog breeders. We identified four major factors that the breeder considered important in relation to the dam: Maternal Care; Offspring Potential; Dam Temperament; and Dam Genetics and Health. Overall, the priorities and practices of dog breeders surveyed were variable across breeds. Importantly, it seemed that not all breeders understood the importance of maternal care behaviour, despite the significant role it may play on future puppy behaviour.AbstractEvery year, thousands of purebred domestic dogs are bred by registered dog breeders. Yet, little is known about the rearing environment of these dogs, or the attitudes and priorities surrounding breeding practices of these dog breeders. The objective of this study was to explore some of the factors that dog breeders consider important for stock selection, with a particular emphasis on issues relating to the dam. Two-hundred and seventy-four Australian purebred dog breeders, covering 91 breeds across all Australian National Kennel Club breed groups, completed an online survey relating to breeding practices. Most breeders surveyed (76%) reported specialising in one breed of dog, the median number of dogs and bitches per breeder was two and three respectively, and most breeders bred two litters or less a year. We identified four components, relating to the dam, that were considered important to breeders. These were defined as Maternal Care, Offspring Potential, Dam Temperament, and Dam Genetics and Health. Overall, differences were observed in attitudes and beliefs across these components, showing that there is variation according to breed/breed groups. In particular, the importance of Maternal Care varied according to dog breed group. Breeders of brachycephalic breeds tended to differ the most in relation to Offspring Potential and Dam Genetics and Health. The number of breeding dogs/bitches influenced breeding priority, especially in relation to Dam Temperament, however no effect was found relating to the number of puppies bred each year. Only 24% of breeders used their own sire for breeding. The finding that some breeders did not test for diseases relevant to their breed, such as hip dysplasia in Labrador Retrievers and German Shepherds, provides important information on the need to educate some breeders, and also buyers of purebred puppies, that screening for significant diseases should occur. Further research into the selection of breeding dams and sires will inform future strategies to improve the health and behaviour of our best friend.

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“…However, the functional role of UCN and its receptors in testicular descent and function needs to be investigated in future studies. In another recent report (Lea et al, 2016), it was postulated that environmental chemicals, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), may increase the incidence of cryptorchidism. However, a direct correlation study between environmental chemicals and cryptorchidism is lacking.…”

Section: Genetic and Molecular Regulation Of Normal Testicular Descmentioning

confidence: 99%

Canine cryptorchidism: An update

Khan

Gartley

Khanam

2018

Reprod Domestic Animals

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This review article is aimed at providing an update on canine cryptorchidism based on the research studies published in this area over the last 26 years. Although a majority of these research studies were directed at investigating the genetic and molecular basis of cryptorchidism, the mechanisms underlying this problem in dogs are still not clear. Future studies using advanced genomic and molecular approaches and including a larger number of dogs of multiple breeds are required to further our understanding of canine cryptorchidism. Diagnosis and treatment of cryptorchidism in dogs have not received much attention. Research advancements include investigation of ultrasonography and anti-Müllerian hormone assay as potential diagnostic methods. Advancements in treatment include the use of laparoscopic-assisted cryptorchidectomy. Based on the available literature, this method appears to be the best for removal of abdominal cryptorchid testes from dogs. However, future studies that compare laparoscopic-assisted cryptorchidectomy with the traditional approaches are required for a more conclusive determination of the best method for cryptorchidectomy in dogs.

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Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism

Cited by 40 publications

References 61 publications

Dog sperm swimming parameters analysed by computer‐assisted semen analysis of motility reveal major breed differences

Dog sperm swimming parameters analysed by computer‐assisted semen analysis of motility reveal major breed differences

Selection of Breeding Stock among Australian Purebred Dog Breeders, with Particular Emphasis on the Dam

Canine cryptorchidism: An update

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