Environmental Degradation Rate Constants

Howard, Philip H.; Boethling, Robert S.; Jarvis, William F.; Meylan, William M.; Michalenko, Edward M.

doi:10.1201/9780203719329-3

Cited by 3 publications

(2 citation statements)

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“…The main concern with ethylene glycol poisoning is that its metabolites, glycolic acid and oxalic acid, cause metabolic acidosis, and the deposition of calcium oxalate in renal tubules causes renal damage (Howard et al 1991). There have been many reports of cases of declined consciousness due to the suppression of the central nervous system as metabolic acidosis progresses and thereby requiring emergency care.…”

Section: Discussionmentioning

confidence: 99%

Ethylene glycol poisoning treated using combination of ethanol and haemodialysis therapy instead of fomepizole: a case report

Une

Kishi

Hidaka

et al. 2021

IJM

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We report a case of ethylene glycol poisoning in a 70-year-old man with headache and dysarthria. Blood tests showed a marked increase in the anion gap (29.8 mOsm/kg) and osmotic gap (14 mOsm/kg). The estimated blood concentration of ethylene glycol was 86.8 mg/dL. Ethanol was administered and he underwent haemodialysis for 7 cycles, which was discontinued on day 12. Fomepizole, which competes with alcohol dehydrogenase, is an effective treatment for ethylene glycol poisoning. However, it is usually prescribed within 24 h after poisoning, and studies on its use in cases of severe acute renal injury over time are limited. We were able to obtain good results with haemodialysis without using fomepizole. Conventional treatments such as haemodialysis may be more useful than fomepizole in terms of cost benefits in patients with addiction who have been taking the drug for a long time or who have advanced renal injury.

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Section: Discussionmentioning

confidence: 99%

Ethylene glycol poisoning treated using combination of ethanol and haemodialysis therapy instead of fomepizole: a case report

Une

Kishi

Hidaka

et al. 2021

IJM

View full text Add to dashboard Cite

show abstract

“…Exposure to organohalogens threatens human health. 40–42 Resistance to biodegradation causes long lifetimes and accumulation of organohalogens in the environment, together with global distribution via waterways. 43 Bioaccumulation through food chains and direct uptake introduce organohalogens into the human body, where they have been linked to Parkinson's disease, 44 harm in cognitive function and development, reproductive, hormonal, and metabolic processes, and increased risk for cancer.…”

Section: Introductionmentioning

confidence: 99%