Environmental enrichment applied with sensory components prevents age-related decline in synaptic dynamics: Evidence from the zebrafish model organism

Karoglu-Eravsar, Elif Tugce; Tuz-Sasik, Melek Umay; Adams, Michelle M.

doi:10.1016/j.exger.2021.111346

Cited by 6 publications

(9 citation statements)

References 82 publications

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“…We also demonstrated that adolescent housing in an EE increased BDNF levels of the hippocampus in both saline and serotonin-depleted groups. These data are in agreement with other studies reporting that the enhancement of cognitive functions under the influence of EE happens not only in healthy animals but also in experimental animals model with different disorders such as brain ischemia (Zhang et al, 2021) and aging (Karoglu-Eravsar et al, 2021;X. Wang et al, 2020).…”

Section: Discussionsupporting

confidence: 93%

Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal brain‐derived neurotrophic factor level following postnatal serotonin depletion in male rats

Saadati

Ghaheri

Sadegzadeh

et al. 2022

Intl J of Devlp Neuroscience

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The neurotransmitter serotonin (5‐HT) is one of the most important modulators of neural circuitry and has a critical role in neural development and functions. Previous studies indicated that changes in serotonergic system signaling in early life critically impact mental health, behavior, the morphology of hippocampal neurons, and cognitive functions across the lifespan. The enriched environment (EE) has indicated beneficial effects on behavior and cognitive functions in the developmental period of life, but its impacts on cognitive impairments and behavioral changes following postnatal serotonin depletion are unknown. Therefore, the present study aimed to evaluate the influences of the EE housing (postnatal days [PNDs] 21–60) following postnatal serotonin depletion (by para‐chlorophenylalanine [PCPA], 100 mg/kg, s.c, in PNDs 10–20) on anxiety‐related behaviors, cognitive functions, and brain‐derived neurotrophic factor (BDNF) mRNA expression in the hippocampus of male rats. Memory and behavioral parameters were examined in early adulthood and after that, the hippocampi of rats were removed to determine the BDNF mRNA expression by PCR (PNDs 60–70). The findings of the present work indicated that adolescent EE exposure alleviated memory impairment, decreased BDNF levels, and anxiety disorders induced by experimental depletion of serotonin. Overall, these results indicate that serotonergic system dysregulation during the developmental periods can be alleviated by adolescent EE exposure.

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Section: Discussionsupporting

confidence: 93%

Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal brain‐derived neurotrophic factor level following postnatal serotonin depletion in male rats

Saadati

Ghaheri

Sadegzadeh

et al. 2022

Intl J of Devlp Neuroscience

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“…More recently, in a pro-inflammatory mouse model, multisensory stimulation reversed memory impairment (Ravache et al, 2023). Karoglu-Eravsar et al (2021) further showed that EE with sensory components prevented age-related decline in synaptic dynamics in zebrafish. EE may lead to the maintenance of cognitive processing at older ages in both humans and animals, consistent with the strong association between social isolation or lower social or cognitive engagement and CF (Section 3.3.1).…”

Section: Resultsmentioning

confidence: 90%

Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

Holland,

Dravecz,

Owens

et al. 2024

Preprint

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Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and physical frailty. While predictors of each element are well-researched, mechanisms of their co-occurrence have not been integrated, particularly in terms of relationships between social, psychological, and biological factors. This interdisciplinary scoping review set out to categorise a heterogenous multidisciplinary literature to identify potential pathways and mechanisms of CF, and research gaps. Studies were included if they used the definition of CF OR focused on conjunction of cognitive impairment and frailty, AND excluded studies on specific disease populations, interventions, epidemiology or prediction of mortality. Searches used Web of Science, PubMed and Science Direct. Search terms included "cognitive frailty" OR (("cognitive decline" OR "cognitive impairment") AND (frail*)), with terms to elicit mechanisms, predictors, causes, pathways and risk factors. To ensure inclusion of animal and cell models, keywords such as "behavioural" or "cognitive decline" or "senescence", were added. 206 papers were included. Descriptive analysis provided high-level categorisation of determinants from social and environmental through psychological to biological. Patterns distinguishing CF from Alzheimer's disease were identified and social and psychological moderators and mediators of underlying biological and physiological changes and of trajectories of CF development were suggested as foci for further research.

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“…Karoglu-Eravsar and collaborators (Karoglu-Eravsar et al, 2021) evaluated adult (6 mpf) and old (27 mpf) zebrafish exposed to EE for 4 weeks. They described global changes in cellular and synaptic markers age-related in zebrafish, such as to decrease in synaptophysin, in the AMPA-type glutamate receptor subunits, and in the postmitotic neuronal marker, and showed that the short-term pre-exposition to EE prevented these changes in old zebrafish.…”

Section: Resultsmentioning

confidence: 99%

“…Gephyrin is an inhibitory scaffolding protein that plays a role as a structural and functional component in inhibitory synapses, and its increase may be related to a protective role against oxidative stress (Groeneweg et al, 2018). In addition, they showed that EE exposure increased brain weight in an age-dependent manner (Karoglu-Eravsar et al, 2021) Old zebrafish pré-exposure to EE showed an increase in brain weight when compared to those in the same condition without EE pré-exposure. However, the same was not observed in adult zebrafish (Groeneweg et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Is environmental enrichment beneficial for laboratory animals? A systematic review of studies in zebrafish

Gallas‐Lopes

Benvenutti²,

Donzelli

et al. 2023

Preprint

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Environmental enrichment (EE) consists of a series of interventions that are carried out in the home environment to provide greater exposure to sensory stimuli with the objective of mimicking the natural habitat for the animals housed in the laboratory, offering a more complex environment like those found in nature. Some studies have shown the positive effects of EE on zebrafish housed in a laboratory environment. However, this evidence is still very recent and accompanied by contradictory results. Furthermore, there is great variability in the protocols applied, and in the conditions of the tests, tanks, and materials used for creating an EE environment. This substantial variability can bring many uncertainties to the development of future studies and hinder the reproducibility and replicability of research. In this context, the main objective of this study was to carry out a systematic review of the literature aiming to provide an overview of the EE protocols used in zebrafish. We conducted a systematic review following PRISMA recommendations. The literature search was performed in PubMed, Scopus, and Web of Science databases and the studies were selected based on inclusion/exclusion criteria. We performed data extraction and risk of bias analysis of the studies included. A total of 901 articles were identified in the databases and 27 of these studies were included in this review. Among these studies, the effect of EE was evaluated as two different proposals. (1) to improve animal welfare and (2) as an intervention for the prevention of some disorders. Although the zebrafish EE protocols presented a series of experimental differences, the results showed that the benefits of the EE for zebrafish were robust. According to the results described here, the use of EE in the zebrafish home tank provides better welfare and may reduce sources of bias in scientific experiments, such as high-stress levels and fighting events.

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Environmental enrichment applied with sensory components prevents age-related decline in synaptic dynamics: Evidence from the zebrafish model organism

Cited by 6 publications

References 82 publications

Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal brain‐derived neurotrophic factor level following postnatal serotonin depletion in male rats

Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal brain‐derived neurotrophic factor level following postnatal serotonin depletion in male rats

Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

Is environmental enrichment beneficial for laboratory animals? A systematic review of studies in zebrafish

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