Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens

Green, Thomas A.; Alibhai, Imran N.; Roybal, C. Nathaniel; Winstanley, Catharine A.; Theobald, David E. H.; Birnbaum, Shari G.; Graham, Ami; Unterberg, Stephen; Graham, Danielle; Vialou, Vincent; Bass, Caroline E.; Terwilliger, Ernest F.; Bardo, Michael T.; Nestler, Eric J.

doi:10.1016/j.biopsych.2009.06.022

Cited by 163 publications

(217 citation statements)

References 27 publications

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“…The relationship of signaling pathways secondary to growth factors with depression-and anxiety-like behavior is another focus of interest. For instance a study has reported that the expression of the active (phosphorylated) form of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) in the NAc was decreased following EE (45). In parallel with this finding, knockdown of CREB in the NAc resulted in decreased depression-like and increased anxiety-like behavior similar to that caused by EE.…”

Section: Alexander Et Al (2010) Investigated the Effect Of P11supporting

confidence: 53%

RNA Interference: A New Hope in Understanding and Treatment of Psychiatric Disorders

Kocak

2012

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Section: Alexander Et Al (2010) Investigated the Effect Of P11supporting

confidence: 53%

RNA Interference: A New Hope in Understanding and Treatment of Psychiatric Disorders

Kocak

2012

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Similar to enhanced sensitization to repeated stimulants, IC rats show greater propensity to selfadminister amphetamine and cocaine relative to EC rats (Bardo et al, 2001;Miczek et al, 2008;Green et al, 2010;Gipson et al, 2011a). This difference is greater at low unit doses than at high unit doses delivered on either FR or PR schedules.…”

Section: B Social Influencesmentioning

confidence: 95%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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“…We used three tests of anxiety-like behavior; the elevated plus-maze (EPM), cold stress defecation, and neophobia to a novel taste (sucrose) (6,16). At the beginning of the EPM test, the rat was placed in the central area facing one of the open arms.…”

Section: Animals and Induction Of Ulcerative Colitis-like Inflammationmentioning

confidence: 99%

“…We employed three tests to model distinct aspects of depression-like behavior: the sucrose preference test to model anhedonia, the social interaction test to model social withdrawal, and the forced swim test to model behavioral despair (16). In the sucrose preference test, rats were preexposed to 1% (wt./vol.)…”

Section: Animals and Induction Of Ulcerative Colitis-like Inflammationmentioning

confidence: 99%

“…Reflexive measures demonstrate hypersensitivity and allodynia evoked by balloon distension, but they do not assess the affective responses (aversive states), because they occur in the absence of balloon distension. The conditioned place preference (18) paradigm rewards the animals with analgesic-induced relief from aversive states, so that they prefer the chamber in which they received treatment (16,18). Ulcerative colitis-like inflammation induces a robust inflammatory response and tissue damage in the affected colon (29).…”

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confidence: 99%

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Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation

Chen

Winston

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation. Am J Physiol Regul Integr Comp Physiol 308: R18-R27, 2015. First published November 1, 2014; doi:10.1152/ajpregu.00298.2014.-Psychological disorders are prevalent in patients with inflammatory bowel disease; the underlying mechanisms remain unknown. We tested the hypothesis that ulcerative colitis-like inflammation induced by dextran sodium sulfate (DSS) exacerbates the ongoing spontaneous activity in colon-projecting afferent neurons that induces abdominal discomfort and anxiety, and depressive-like behaviors in rats. In this study, we used the conditioned place preference and standard tests for anxiety-and depression-like behaviors. DSS rats developed anxiety-and depression-like behaviors 10 to 20 days after the start of inflammation. Single-fiber recordings showed an increase in the frequency of spontaneous activity in L6-S1 dorsal root ganglion (DRG) roots. Prolonged desensitization of transient receptor potential vanilloid 1 (TRPV1)-expressing colonic afferents by resiniferatoxin (RTX) suppressed the spontaneous activity, as well as the anxiety-and depressive-like behaviors. Reduction in spontaneous activity in colon afferents by intracolonic administration of lidocaine produced robust conditioned place preference (CPP) in DSS rats, but not in control rats. Patchclamp studies demonstrated a significant decrease in the resting membrane potential, lower rheobase, and sensitization of colonprojecting L6-S1 DRG neurons to generate trains of action potentials in response to current injection in DSS rats. DSS inflammation upregulated the mRNA levels of transient receptor potential ankyrin 1 and TRPV1 channels and downregulated that of K v1.1 and Kv1.4 channels. Ulcerative colitis-like inflammation in rats induces anxietyand depression-like behaviors, as well as ongoing abdominal discomfort by exacerbating the spontaneous activity in the colon-projecting afferent neurons. Alterations in the expression of voltage-and ligandgated channels are associated with the induction of mood disorders following colon inflammation.inflammatory bowel disease; spontaneous activity in visceral afferent neurons; anxiety; depression; visceral hypersensitivity ACCUMULATING EVIDENCE SHOWS that peripheral inflammation in chronic diseases, including Type 1 diabetes, cardiovascular disease, asthma, rheumatoid arthritis, chronic pulmonary disease, and chronic hepatitis C, associates with anxiety and depression in vulnerable patients (7). Inflammatory bowel disease (IBD) causes intense overt inflammation in the distal gut. The prevalence of psychological disorders is controversial in IBD patients (20). However, various reports show that as high as 80% of IBD patients suffer from anxiety and 60% from depression during relapse (1) and 29% to 35% during remission (3, 22). The cellular and neurological mechanisms by which peripheral inflammation induces anxiety and depression remain unknown.Evoked pain induced by balloon distension in the col...

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Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens

Cited by 163 publications

References 27 publications

RNA Interference: A New Hope in Understanding and Treatment of Psychiatric Disorders

RNA Interference: A New Hope in Understanding and Treatment of Psychiatric Disorders

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation

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