Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus

Rasmuson, Sigbritt; Olsson, Tommy; Henriksson, Bengt G.; Kelly, Paul A.; Holmes, Megan C.; Seckl, Jonathan R.; Mohammed, Abdul K.

doi:10.1016/s0169-328x(97)00317-3

Cited by 118 publications

(61 citation statements)

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“…21 At the molecular level, EE causes a significant change in the expression of a large set of genes involved in neuronal structure, excitability, synaptic transmission and plasticity, 23 modulating the synthesis and secretion of neurotrophic factors throughout the brain and affecting the cholinergic, serotoninergic and noradrenergic systems. [24][25][26][27] Although EE research has been mostly focused on rodents, similar effects have been reported in several species of mammals (gerbils, ground squirrels, rabbits, cats and primates). [28][29][30][31][32] …”

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confidence: 71%

“…Subsequent studies confirmed and extended this initial observation to other neurotransmitter systems, showing that EE increases noradrenaline concentration and strengthens the b-adrenoceptor signalling pathway in the cerebral cortex, cerebellum and brainstem, 27,103 and augments mRNA expression levels of serotonin 1A receptor and serotonin (5-HT) concentration in the cerebral cortex and hippocampus. 25,104,105 Interestingly, in vitro studies have repeatedly reported that 5-HT, acetylcholine, dopamine and, to a lesser extent, noradrenaline, suppress inhibition in several brain regions, including the visual cortex, possibly through a presynaptic mechanism mediated, respectively, by 5-HT 1/2 , muscarinic D1 and the a-adrenergic receptor families. [106][107][108][109][110][111][112][113] Moreover, very recently, a modification of visual cortex pyramidal neuron responses to input signals depending on the behavioural state has been observed, related to a bidirectional modulation of somatic inhibition.…”

Section: Impact Of Ee On the Brain L Baroncelli Et Almentioning

confidence: 99%

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Nurturing brain plasticity: impact of environmental enrichment

et al. 2009

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Environmental enrichment (EE) is known to profoundly affect the central nervous system (CNS) at the functional, anatomical and molecular level, both during the critical period and during adulthood. Recent studies focusing on the visual system have shown that these effects are associated with the recruitment of previously unsuspected neural plasticity processes. At early stages of brain development, EE triggers a marked acceleration in the maturation of the visual system, with maternal behaviour acting as a fundamental mediator of the enriched experience in both the foetus and the newborn. In adult brain, EE enhances plasticity in the cerebral cortex, allowing the recovery of visual functions in amblyopic animals. The molecular substrate of the effects of EE on brain plasticity is multi-factorial, with reduced intracerebral inhibition, enhanced neurotrophin expression and epigenetic changes at the level of chromatin structure. These findings shed new light on the potential of EE as a non-invasive strategy to ameliorate deficits in the development of the CNS and to treat neurological disorders.

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confidence: 71%

Section: Impact Of Ee On the Brain L Baroncelli Et Almentioning

confidence: 99%

Nurturing brain plasticity: impact of environmental enrichment

et al. 2009

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“…This question can not be addressed without further studies combining molecular biology with behavioral testing. Importantly however, changes in 5-HT 1A mRNA expression, at least in the hippocampus and raphe nuclei, are usually paralleled by changes in 5-HT 1A binding sites [28, 29, 30, 31]and 5-HT 1A receptor protein [32]which strongly argues for translation of the transcriptional effects seen. Moreover, the anxiogenic behavioural deficits in 5-HT 1A receptor knockout mice are seen in an attenuated form in heterozygotes, which have half the level of 5-HT 1A receptors of wild-type mice, suggesting that 5-HT 1A -determined behaviors are sensitive to mRNA density [33].…”

Section: Discussionmentioning

confidence: 99%

Serotonin 5-HT<sub>1A</sub> Receptor mRNA Expression in Dorsal Hippocampus and Raphe Nuclei after Gonadal Hormone Manipulation in Female Rats

et al. 2001

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Female ovarian steroids influence mood and cognition, an effect presumably mediated by the serotonergic system. A key receptor in this interplay may be the 5-HT_1A receptor subtype. We gave adult ovariectomized female rats subcutaneous pellets containing different dosages of 17β-estradiol alone or in combination with progesterone, or placebo pellets, for 2 weeks. 5-HT_1A receptor mRNA levels were analyzed by in situ hybridization in the dorsal hippocampus, dorsal and median raphe nuclei, and entorhinal cortex. Estradiol treatment alone reduced 5-HT_1A gene expression in the dentate gyrus and the CA2 region (17 and 19% decrease, respectively). Estradiol combined with progesterone supplementation increased 5-HT_1A gene expression versus placebo in the CA1 and CA2 subregions of the dorsal hippocampus (16 and 30% increase, respectively). Concomitantly, 5-HT_1A mRNA expression was decreased by 13% in the ventrolateral part of the dorsal raphe nuclei, while no changes were found in the median raphe nucleus and entorhinal cortex. Chronic effects of ovarian hormones on 5-HT_1A receptor mRNA expression appear tissue-specific and involve hippocampal subregions and the raphe nuclei. Modulation of 5-HT_1A receptor gene expression may be of importance for gonadal steroid effects on mood and cognition.

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“…Thus, through increased levels of various neurotrophic factors, environmental enrichment likely decreases the vulnerability of the brain to neurodegeneration following environmental insults and injury. Furthermore, environmental enrichment modulates cholinergic (Rosenzweig and Bennett, 1996;Del Arco et al, 2007;van Praag et al, 2000), serotonin-ergic (Rasmuson et al, 1998), dopaminergic (Bezard et al, 2003;Bowling et al, 1993;Del Arco et al, 2007) and glutamatergic neurotransmission (Foster et al, 1996;Bredy et al, 2004;Naka et al, 2005;Mlynarik et al, 2004). Moreover, adult rats placed in an enriched environment demonstrated increased levels of proteins involved in learning and memory function.…”

Section: Alterations In Brain Chemistrymentioning

confidence: 99%

Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?

Dhanushkodi

Shetty

2008

Neuroscience & Biobehavioral Reviews

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Exposure to environmental enrichment has been shown to induce robust neuronal plasticity in both intact and injured adult central nervous system, including up-regulation of multiple neurotrophic factors, enhanced neurogenesis in the dentate gyrus of the hippocampus, and improved spatial learning and memory function. Neuronal plasticity, though mostly adaptive and abnormal, also occurs during certain neurodegenerative conditions such as the temporal lobe epilepsy (TLE). The TLE is characterized by hippocampal neurodegeneration, aberrant mossy fiber sprouting, spontaneous recurrent motor seizures, cognitive deficits, and abnormally enhanced neurogenesis during the early phase and dramatically declined neurogenesis during the chronic phase of the disease. As enrichment has been found to be beneficial for treating animal models of Alzheimer's, Parkinson's, and Huntington's diseases, there is considerable interest in determining the efficacy of this strategy for preventing or treating chronic TLE after the initial precipitating brain injury. This review first discusses the proof of principle behind the potential application of the environmental enrichment strategy for preventing or treating TLE after brain injury. The subsequent chapters confer the portrayed beneficial effects of enrichment for functional post-lesional recovery in TLE and the possible complications which may arise from housing epilepsy-prone or epileptic rats in enriched environmental conditions. The final segment discusses studies that are essential for further understanding the efficacy of this approach for preventing or treating TLE.

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Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus

Cited by 118 publications

References 30 publications

Nurturing brain plasticity: impact of environmental enrichment

Nurturing brain plasticity: impact of environmental enrichment

Serotonin 5-HT<sub>1A</sub> Receptor mRNA Expression in Dorsal Hippocampus and Raphe Nuclei after Gonadal Hormone Manipulation in Female Rats

Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?

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