Environmental exposures and family history of asthma

Sheikh, Shahid; Pitts, Judy; Ryan‐Wenger, Nancy A.; McCoy, Karen; Hayes, Don

doi:10.3109/02770903.2015.1108440

Cited by 19 publications

(21 citation statements)

References 28 publications

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“…In addition, we showed that CSE preferably induces CD4+ T cells to differentiate into Th2 cells via DCs. Epidemiologic, laboratory, and clinical studies clearly demonstrate that cigarette smoking is an important risk factor in Th2-mediated diseases such as asthma [32]. The role of DC-mediated Th1 and Th2 immunity is regulated by many factors, including Ag type and dose, the expression level of costimulatory molecules [33], the existence of polarizing cytokines and other mediators, and the time of exposure to the presence of innate receptor stimulants [34].…”

Section: Discussionmentioning

confidence: 99%

Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways

Jiang

Xia

et al. 2018

Int Arch Allergy Immunol

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Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Stimulated by CSE, immature DCs from murine bone marrow showed upregulated levels of TIM4. Cocultured with CD4+ T cells, stimulated DCs increased the ratio of IL-4+ versus IFN-γ+ of CD4+ T cells. This suggests a differentiation towards Th2 response. Moreover, antibodies against TIM4 reversed the upexpression of the IL-4+/IFN-γ+ ratio provoked by CSE, indicating that the Th2 polarization which was induced by CSE is via TIM4 mechanisms. CSE could activate mitogen-activated protein kinase pathways like ERK and p38. Upregulation of TIM4 expression by CSE stimulation was found to be inhibited by an ERK inhibitor but not p38 and JNK. In conclusion, DC-induced Th2 polarization is a hallmark of CSE allergy, and this aspect can be explained by CSE-induced TIM4 expression.

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Section: Discussionmentioning

confidence: 99%

Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways

Jiang

Xia

et al. 2018

Int Arch Allergy Immunol

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“…The rates of asthma and allergies continue to grow [72,73,74], where a combination of factors have played a role in the increasing rates, including increased rates of diagnosis [75]. For asthma, there are some common findings among studies for causal and related factors, such as positive association of a child’s asthma outcome with atopy, parental atopy and asthma, indoor and outdoor pollution, and a negative association with living in a rural area [53,73,74,76,77,78].…”

Section: Approachmentioning

confidence: 99%

A Review of the Field on Children’s Exposure to Environmental Contaminants: A Risk Assessment Approach

Ferguson

Penney

Solo‐Gabriele

2017

IJERPH

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Background: Children must be recognized as a sensitive population based on having biological systems and organs in various stages of development. The processes of absorption, distribution, metabolism and elimination of environmental contaminants within a child’s body are considered less advanced than those of adults, making them more susceptible to disease outcomes following even small doses. Children’s unique activities of crawling and practicing increased hand-to-mouth ingestion also make them vulnerable to greater exposures by certain contaminants within specific environments. Approach: There is a need to review the field of children’s environmental exposures in order to understand trends and identify gaps in research, which may lead to better protection of this vulnerable and sensitive population. Therefore, explored here are previously published contemporary works in the broad area of children’s environmental exposures and potential impact on health from around the world. A discussion of children’s exposure to environmental contaminants is best organized under the last four steps of a risk assessment approach: hazard identification, dose-response assessment, exposure assessment (including children’s activity patterns) and risk characterization. We first consider the many exposure hazards that exist in the indoor and outdoor environments, and emerging contaminants of concern that may help guide the risk assessment process in identifying focus areas for children. A section on special diseases of concern is also included. Conclusions: The field of children’s exposures to environmental contaminants is broad. Although there are some well-studied areas offering much insight into children exposures, research is still needed to further our understanding of exposures to newer compounds, growing disease trends and the role of gene-environment interactions that modify adverse health outcomes. It is clear that behaviors of adults and children play a role in reducing or increasing a child’s exposure, where strategies to better communicate and implement risk modifying behaviors are needed, and can be more effective than implementing changes in the physical environment.

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“…History of asthma in parents, siblings or grandparents was reported by Sheikh et al study in 575 (69.8%) patients including father (17.8%) and mother (26.5%) (Sheikh et al, 2016).…”

Section: Discussionmentioning

confidence: 93%

Study of Candida albicans & Aspergillus fumigatus Sensitization among Egyptian patients with allergic Bronchial Asthma

Ali¹,

Latif²,

Sayed³

et al. 2017

Int. J. Adv. Res. Biol. Sci

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Asthma is a major cause of disability, health resource utilization and poor quality of life for those who are affected. The global prevalence rates of doctor diagnosed asthma, clinical/treated asthma and wheezing in adults were 4.3%, 4.5%, and 8.6% respectively among 70 countries. Sensitization to fungi is an important factor in patients with allergic respiratory tract diseases, playing a major role in the development, persistence, and severity of lower airway disease, particularly asthma. The aim of this study was to determine the sensitization to Candida albicans and Aspergillus fumigatus fungi among Egyptian patients with allergic Asthma. This design of this study was cross-sectional, with enrolling of consecutive 100 adult asthmatic patients attended the allergy outpatient clinic; Ain Shams University hospital in the years 2015-2016. We found that 28 and 12 patients had positive Skin Prick Test to Candida albicans and Aspergillus fumigatus respectively, from those 22 and 10 were positive at Broncho-provocation test with positive predictive value of skin prick test 78.6% for Candida albicans and 83.3% for Aspergillus fumigatus.

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Environmental exposures and family history of asthma

Cited by 19 publications

References 28 publications

Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways

Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways

A Review of the Field on Children’s Exposure to Environmental Contaminants: A Risk Assessment Approach

Study of Candida albicans & Aspergillus fumigatus Sensitization among Egyptian patients with allergic Bronchial Asthma

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