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Introduction: iga deficiency is one of the commonest primary antibody deficiencies. although many affected individuals could be asymptomatic, selected patients suffer from recurrent mucosal infections, allergies, and autoimmune diseases.Aim of the study: to investigate the prevalence of iga deficiency among egyptian patients with food allergy.Material and methods: we studied 100 patients (62 males, 38 females; mean age, 28.6 years) with multiple food allergies who were recruited on the basis of adequate immunological assessment by history, skin prick test, and confirmed by open challenge test as well as 50 healthy controls. measurement of levels of ige and iga using elisa technique were performed for all patients and controls.Results: deficiency of iga was detected in 67% of patients with food allergy. serum iga levels were significantly lower among patients with food allergy (67.3 μg/ml; range, 56.7-72.0 μg/ml) as compared to healthy control (78.6 μg/ml; range, 72.8-84 μg/ml). both iga and ige levels were not statistically different between patients with food allergy only and those with combined food and aeroallergen. among food allergic group, serum IgA levels were inversely correlated with serum IgE levels (r = -0.314, p < 0.001).Conclusions: manifestations of atopy, such as food allergy might be a present feature before diagnosis of primary immune deficiency diseases as iga deficiency.

Asthma is a major cause of disability, health resource utilization and poor quality of life for those who are affected. The global prevalence rates of doctor diagnosed asthma, clinical/treated asthma and wheezing in adults were 4.3%, 4.5%, and 8.6% respectively among 70 countries. Sensitization to fungi is an important factor in patients with allergic respiratory tract diseases, playing a major role in the development, persistence, and severity of lower airway disease, particularly asthma. The aim of this study was to determine the sensitization to Candida albicans and Aspergillus fumigatus fungi among Egyptian patients with allergic Asthma. This design of this study was cross-sectional, with enrolling of consecutive 100 adult asthmatic patients attended the allergy outpatient clinic; Ain Shams University hospital in the years 2015-2016. We found that 28 and 12 patients had positive Skin Prick Test to Candida albicans and Aspergillus fumigatus respectively, from those 22 and 10 were positive at Broncho-provocation test with positive predictive value of skin prick test 78.6% for Candida albicans and 83.3% for Aspergillus fumigatus.

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