Selective IgA Deficiency a Probable Risk of Recurrent Chest Infections in Asthmatics

Ali, Fawzia Hassan Abo; Mahmoud, Nehal Elfawy; El-Sayed, Amr Yakout Mohamed; Abdelmaksoud, Mariam Fathy; Shata, Alaa K; Fouad, Shaimaa H

doi:10.2147/jaa.s329531

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…In a study done by Shkalim et al among children in Israel, it was found that that asthma was the most common allergic disease in patients with selective immunoglobulin A deficiency (SIgAD), based on evaluation of their clinical and immunological characteristics [ 61 ]. This may be related to the fact that patients with SIgAD cannot neutralize or prevent the absorption of allergens so they are prone to allergic diseases, such as asthma and food allergy [ 34 ]. Urm et al conducted a case–control study and found that asthma patients are more susceptible to SIgAD than non-asthma patients, and SIgAD increases the risk of bacterial infections and recurring infections among patients with asthma.…”

Section: The Relationship Between Siga and Pulmonary Diseasesmentioning

confidence: 99%

“…Urm et al conducted a case–control study and found that asthma patients are more susceptible to SIgAD than non-asthma patients, and SIgAD increases the risk of bacterial infections and recurring infections among patients with asthma. It was also found that an elevated white blood cell count is associated with low levels of serum IgA in asthma patients with recurring infections [ 34 , 61 – 64 ]. However, some studies have concluded that SIgAD, as an immunodeficiency disease, may be related to increased serum IgE levels [ 61 ].…”

Section: The Relationship Between Siga and Pulmonary Diseasesmentioning

confidence: 99%

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SIgA in various pulmonary diseases

Wang,

Zhang,

et al. 2023

Eur J Med Res

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Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes among mucosa, which plays an indispensable role in the first-line protection against invading pathogens and antigens. Therefore, the role of respiratory SIgA in respiratory mucosal immune diseases has attracted more and more attention. Although the role of SIgA in intestinal mucosal immunity has been widely studied, the cell types responsible for SIgA and the interactions between cells are still unclear. Here, we conducted a wide search of relevant studies and sorted out the relationship between SIgA and some pulmonary diseases (COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, lung cancer), which found SIgA is involved in the pathogenesis and progression of various lung diseases, intending to provide new ideas for the prevention, diagnosis, and treatment of related lung diseases.

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Section: The Relationship Between Siga and Pulmonary Diseasesmentioning

confidence: 99%

Section: The Relationship Between Siga and Pulmonary Diseasesmentioning

confidence: 99%

SIgA in various pulmonary diseases

Wang,

Zhang,

et al. 2023

Eur J Med Res

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“…Severe asthma patients present with lower serum IgA levels compared to healthy controls and lower S-IgA levels were negatively correlated with lung function and positively with asthma symptoms ( 130 ). A recent study shows significantly lower serum IgA levels in asthmatics with recurrent infections ( 131 ). As shown in COPD, IgA levels were correlated to eosinophil activation in previous studies, with correlations between IgA (total and allergen-specific) and eosinophilic cationic protein (ECP) as marker of eosinophil degranulation.…”

Section: Role Of Iga In Lower Airway Diseasementioning

confidence: 99%

The Role of IgA in Chronic Upper Airway Disease: Friend or Foe?

et al. 2022

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Chronic upper airway inflammation is amongst the most prevalent chronic disease entities in the Western world with prevalence around 30% (rhinitis) and 11% (rhinosinusitis). Chronic rhinitis and rhinosinusitis may severely impair the quality of life, leading to a significant socio-economic burden. It becomes more and more clear that the respiratory mucosa which forms a physiological as well as chemical barrier for inhaled particles, plays a key role in maintaining homeostasis and driving disease. In a healthy state, the mucosal immune system provides protection against pathogens as well as maintains a tolerance toward non-harmful commensal microbes and benign environmental substances such as allergens. One of the most important players of the mucosal immune system is immunoglobulin (Ig) A, which is well-studied in gut research where it has emerged as a key factor in creating tolerance to potential food allergens and maintaining a healthy microbiome. Although, it is very likely that IgA plays a similar role at the level of the respiratory epithelium, very little research has been performed on the role of this protein in the airways, especially in chronic upper airway diseases. This review summarizes what is known about IgA in upper airway homeostasis, as well as in rhinitis and rhinosinusitis, including current and possible new treatments that may interfere with the IgA system. By doing so, we identify unmet needs in exploring the different roles of IgA in the upper airways required to find new biomarkers or therapeutic options for treating chronic rhinitis and rhinosinusitis.

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