Environmental Factors and Endometriosis

Polak, Grzegorz; Banaszewska, Beata; Filip, Michał; Radwan, Michał; Wdowiak, Artur

doi:10.3390/ijerph182111025

Cited by 22 publications

(37 citation statements)

References 61 publications

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“…In two independent reviews, both Parazzini et al 19 and later Osmanlioglu et al 22 agreed that evidence supporting a significant association between diet and endometriosis is equivocal. Polak et al 21 could not take out any significant conclusions about the relation between…”

Section: Discussionmentioning

confidence: 96%

“…A consequent important issue is to establish whether and how promoters of inflammation could influence endometriosis risk 15,16 . It is not surprising that modifiable lifestyle factors, such as diet, caffeine, environment, and smoking, all factors possibly associated with inflammation, have been explored in this regard [17][18][19][20][21][22][23][24] . Alcohol has already gained a certain attention.…”

Section: A Systematic Review and Meta-analysis On Alcohol Consumption...mentioning

confidence: 99%

See 1 more Smart Citation

A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

Piani

Chiaffarino

Cipriani

et al. 2022

Sci Rep

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Endometriosis is a complex and chronic disease, whose multifactorial nature has encouraged a deep investigation on the role of lifestyle factors. A strong association between alcohol intake and endometriosis risk has already been shown. We aimed to confirm this association, considering the updated literature. 23 eligible studies were identified through comprehensive literature search of PubMed and EMBASE (May 2012–October 2021). A borderline statistical significance was found comparing any alcohol consumption with no consumption (unadjusted OR 1.14; 95% CI: 0.99–1.31, p = 0.06), in contrast with a previous meta-analysis. However, we confirmed the significant association between moderate alcohol intake and endometriosis (unadjusted OR 1.22, 95% CI: 1.03–1.45, p = 0.02), also performing a sensitivity analysis (unadjusted OR 1.27, 95% CI: 1.04–1.54). Our partly divergent evidence reflects the tough challenge of isolating the impact of specific factors on the natural history of multifactorial diseases. Indeed, on one hand alcohol could be adopted by patients as a self-management therapy and on the other, it could favor the disease, promoting positive feedback with inflammatory mediators and oxidative stress. Our study encourages further investigation on the role of modifiable lifestyle factors and highlights the opportunity to adopt them to prevent or at least limit endometriosis progression.

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Section: Discussionmentioning

confidence: 96%

Section: A Systematic Review and Meta-analysis On Alcohol Consumption...mentioning

confidence: 99%

A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

Piani

Chiaffarino

Cipriani

et al. 2022

Sci Rep

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show abstract

“…Clinical and experimental data also indicate that exposure to EDCs affects fertility by interfering with multiple processes, including folliculogenesis, steroidogenesis, ovulation, fertilization, and gestation, which means EDCs disrupt ovarian function and fertility ( Figure 1 ). Numerous studies have suggested that exposure to EDCs may increase the incidence of uterine fibroids by promoting estrogen-dependent hyperplasia of the myometrium, endometriosis, premature ovarian failure, and polycystic ovary syndrome (PCOS) [ 49 , 50 , 51 , 52 ]. In addition, exposure to EDCs during early gestation disrupts intrauterine implantation and uterine reception, leading to implantation failure [ 53 ].…”

Section: Disease Endpoints In Relation To Edcsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Disease Endpoints

Ahn

Jeung

2023

IJMS

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Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and have been shown to interfere with physiological systems, especially by disrupting the hormone balance. During the last few decades, EDCs have been shown to affect reproductive, neurological, and metabolic development and function and even stimulate tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals have endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates. These compounds have gradually been elucidated as risk factors for many diseases, such as reproductive, neural, and metabolic diseases and cancers. Endocrine disruption has been spread to wildlife and species that are connected to the food chains. Dietary uptake represents an important source of EDC exposure. Although EDCs represent a significant public health concern, the relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and the disease endpoints associated with endocrine disruption for a better understanding of the relationship between EDCs-disease and elucidates the development of new prevention/treatment opportunities and screening methods.

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“…Koike et al showed that in mice exposed to DES, constant expression of the lactoferrin and EGF genes can be observed in the vagina and uterus [ 63 ]. Furthermore, Wang et al hypothesized that EGF could stimulate endometriosis cell proliferation by activating the Ras/Raf/MEK/ERK pathway [ 72 , 73 , 74 ].…”

Section: Environmental Impactmentioning

confidence: 99%

Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

2023

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Endometriosis is a chronic disease caused by ectopic endometrial tissue. Endometriotic implants induce inflammation, leading to chronic pain and impaired fertility. Characterized by their dependence on estradiol (via estrogen receptor β (ESRβ)) and their resistance to progesterone, endometriotic implants produce their own source of estradiol through active aromatase. Steroidogenic factor-1 (SF1) is a key transcription factor that promotes aromatase synthesis. The expression of SF1 and ESRβ is enhanced by the demethylation of their promoter in progenitor cells of the female reproductive system. High local concentrations of estrogen are involved in the chronic inflammatory environment favoring the implantation and development of endometriotic implants. Similar local conditions can promote, directly and indirectly, the appearance and development of genital cancer. Recently, certain components of the microbiota have been identified as potentially promoting a high level of estrogen in the blood. Many environmental factors are also suspected of increasing the estrogen concentration, especially prenatal exposure to estrogen-like endocrine disruptors such as DES and bisphenol A. Phthalates are also suspected of promoting endometriosis but throughmeans other than binding to estradiol receptors. The impact of dioxin or tobacco seems to be more controversial.

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Environmental Factors and Endometriosis

Cited by 22 publications

References 61 publications

A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

Endocrine-Disrupting Chemicals and Disease Endpoints

Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

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