Environmental Factors and Psoriasis1

Dika, Emi; Bardazzi, F; Balestri, Riccardo; Maibach, H I

doi:10.1159/000106419

Cited by 45 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering the additional influence of environmental factors [78], it is tempting to argue that studies focused exclusively on genetically homogenous inbred mice, despite all their advantages, can never succeed in fully replicating human diseases and their complexity [79]. An advantage of IMQ, however, is its flexibility and convenience as an experimental approach, which in this study allowed us to demonstrate strain- and sex-dependent effects.…”

Section: Discussionmentioning

confidence: 99%

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

et al. 2017

View full text Add to dashboard Cite

BackgroundImiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. Such effects, however, could lead to conflicts among studies, while further impacting study outcomes and efforts to translate research findings.MethodsRNA-seq was used to evaluate the psoriasiform phenotype elicited by 6 days of Aldara (5% IMQ) treatment in both sexes of seven mouse strains (C57BL/6 J (B6), BALB/cJ, CD1, DBA/1 J, FVB/NJ, 129X1/SvJ, and MOLF/EiJ).ResultsIn most strains, IMQ altered gene expression in a manner consistent with human psoriasis, partly due to innate immune activation and decreased homeostatic gene expression. The response of MOLF males was aberrant, however, with decreased expression of differentiation-associated genes (elevated in other strains). Key aspects of the IMQ response differed between the two most commonly studied strains (BALB/c and B6). Compared with BALB/c, the B6 phenotype showed increased expression of genes associated with DNA replication, IL-17A stimulation, and activated CD8+ T cells, but decreased expression of genes associated with interferon signaling and CD4+ T cells. Although IMQ-induced expression shifts mirrored psoriasis, responses in BALB/c, 129/SvJ, DBA, and MOLF mice were more consistent with other human skin conditions (e.g., wounds or infections). IMQ responses in B6 mice were most consistent with human psoriasis and best replicated expression patterns specific to psoriasis lesions.ConclusionsThese findings demonstrate strain-dependent aspects of IMQ dermatitis in mice. We have shown that IMQ does not uniquely model psoriasis but in fact triggers a core set of pathways active in diverse skin diseases. Nonetheless, our findings suggest that B6 mice provide a better background than other strains for modeling psoriasis disease mechanisms.Electronic supplementary materialThe online version of this article (doi:10.1186/s13073-017-0415-3) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Environmental triggers that may precipitate or exacerbate psoriasis include endocrine factors, infections, trauma, drugs, psychological stress, obesity, smoking and alcohol consumption. 1 Alcohol intake is significantly greater in patients with psoriasis compared with normal controls, but the question is often raised: Does alcohol cause psoriasis or psoriasis cause alcoholism? A recent study showed a small but significant association between alcohol intake and anxiety and depression in patients with psoriasis, therefore it is possible that these individuals use alcohol to handle distress.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and alcohol: is cutaneous ethanol one of the missing links?

Farkas

Kemény

2009

British Journal of Dermatology

View full text Add to dashboard Cite

Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, and decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin, cyclin D1 and keratinocyte growth factor receptor. Recently the correlation between blood and skin ethanol levels in humans was determined by a transdermal alcohol monitoring device, against the 'gold standard' breath alcohol readings. Based on transdermal alcohol measurements it can be concluded that cutaneous alcohol concentrations can reach levels that induce proinflammatory cytokine production and lymphocyte and keratinocyte proliferation in vitro. It is expected that the development of methodologies measuring transdermal ethanol will provide additional tools to evaluate how alcohol influences skin physiology and different dermatological conditions including psoriasis. Our review focuses on the possible link between alcohol misuse and psoriasis, particularly on the possible role of cutaneous ethanol in precipitating the disease.

show abstract

“…Psoriasis, atopic dermatitis, rosacea and acne are all widely believed to be exacerbated by stress. Although controlled trials are difficult, there are a number of reports indicating that stress can exacerbate these conditions (Dika et al, 2007; Arndt et al, 2008; Sowińska-Glugiewicz et al, 2005; Yosipovitch et al, 2007) and that alleviation of stress can improve some of them, such as atopic dermatitis and psoriasis (Ersser et al, 2007; Zacharieae et al, 1996). In support of this concept, there are animal models demonstrating enhancement of inflammatory skin disorders by experimental stressors (Amano et al, 2008; Pavlovic et al, 2008).…”

Section: Clinical Relevancementioning

confidence: 99%

Nerve-derived transmitters including peptides influence cutaneous immunology

Madva

Granstein

2013

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Clinical observations suggest that the nervous and immune systems are closely related. For example, inflammatory skin disorders; such as psoriasis, atopic dermatitis, rosacea and acne; are widely believed to be exacerbated by stress. A growing body of research now suggests that neuropeptides and neurotransmitters serve as a link between these two systems. Neuropeptides and neurotransmitters are released by nerves innervating the skin to influence important actors of the immune system, such as Langerhans cells and mast cells, which are located within close anatomic proximity. Catecholamines and other sympathetic transmitters that are released in response to activation of the sympathetic nervous system are also able to reach the skin and affect immune cells. Neuropeptides appear to direct the outcome of Langerhans cell antigen presentation with regard to the subtypes of Th cells generated and neuropeptides induce the degranulation of mast cells, among other effects. Additionally, endothelial cells, which release many inflammatory mediators and express cell surface molecules that allow leukocytes to exit the bloodstream, appear to be regulated by certain neuropeptides and transmitters. This review focuses on the evidence that products of nerves have important regulatory activities on antigen presentation, mast cell function and endothelial cell biology. These activities are highly likely to have clinical and therapeutic relevance.

show abstract

Environmental Factors and Psoriasis1

Cited by 45 publications

References 0 publications

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

Psoriasis and alcohol: is cutaneous ethanol one of the missing links?

Nerve-derived transmitters including peptides influence cutaneous immunology

Contact Info

Product

Resources

About