Environmental factors shaping the gut microbiome in a Dutch population

Gaćeša, Ranko; Kurilshikov, Alexander; Vila, Arnau Vich; Sinha, Trishla; Klaassen, Marjolein A Y; Bolte, Laura A; Andreu‐Sánchez, Sergio; Chen, Lianmin; Collij, Valerie; Hu, Shixian; Dekens, Jackie; Lenters, Virissa; Björk, Johannes; Swarte, J Casper; Swertz, Morris A.; Jansen, Bernadien H.; Gelderloos-Arends, Jody; Jankipersadsing, Soesma A; Hofker, Marten H.; Vermeulen, Roel; Sanna, Serena; Harmsen, Hermie J. M.; Wijmenga, Cisca; Fu, Jingyuan; Zhernakova, Alexandra; Weersma, Rinse K.

doi:10.1038/s41586-022-04567-7

Cited by 392 publications

(363 citation statements)

References 78 publications

Supporting

Mentioning

339

Contrasting

Order By: Relevance

“…F. prausnitzii has been shown to have anti-inflammatory effects, to produce the SCFA butyrate and has been associated with improving the intestinal barrier by increasing levels of tight junction proteins occludin and E-cadherin (Carlsson et al, 2013;He, Zhao, & Li, 2021;Laval et al, 2015;Martín et al, 2015). Next to that, F. prausnitzii has been associated with smoking, which is in line with the fact that the percentage of smokers is higher in psychiatric disorders (Gacesa et al, 2022;Lê Cook et al, 2014). Multiple of the findings, like higher relative abundances of Actinobacteria and lower Psychological Medicine abundancy of Prevotella in MDD have been associated unhealthy dietary patterns.…”

Section: Actinobacteriamentioning

confidence: 60%

“…Moreover, the recently published systematic review and meta-analysis of Nikolova et al ( 2021 ) observed depleted levels of Faecalibacterium in BD, MDD and schizophrenia as well. Faecalibacterium , especially species Faecalibacterium prausnitzii , is usually considered a ‘good’ gut bacterium and is associated with positive healthy outcomes, and its depletion with negative healthy outcomes (Ferreira-Halder, de Faria, & Andrade, 2017 ; Gacesa et al, 2022 ). Furthermore, F. prausnitzii was negatively associated with MDD (Gacesa et al, 2022 ).…”

Section: Gm In Three Major Psychiatric Disordersmentioning

confidence: 99%

“…The human gut microbiome (GM), comprised of trillions of microorganisms, bacteria, viruses, fungi and other life forms, has been implicated in numerous aspects of human health and disease (Lai, Gao, & Zhang, 2020 ). The GM is diverse, personalized, dynamic and can be influenced, especially early in life, by factors such as vaginal/caesarean birth, diet, sleep, contact with other humans and stress (Gacesa et al, 2022 ; Szeligowski, Yun, Lennox, & Burnet, 2020 ). However, genetic factors, especially immunological background also determine a person's microbiome composition (Thaiss, Zmora, Levy, & Elinav, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of the gut microbiome in three major psychiatric disorders

et al. 2022

View full text Add to dashboard Cite

Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia-spectrum disorders (SSD) are heterogeneous psychiatric disorders, which place significant burden on patient's well-being and global health. Disruptions in the gut-microbiome may play a role in these psychiatric disorders. This review presents current data on composition of the human gastrointestinal microbiota, and its interaction mechanisms in the gut–brain axis in MDD, BD and SSD. Diversity metrics and microbial relative abundance differed across studies. More studies reported inconsistent findings (n = 7) or no differences (n = 8) than studies who reported lower α-diversity in these psychiatric disorders (n = 5). The most consistent findings across studies were higher relative abundances of the genera Streptococcus, Lactobacillus, and Eggerthella and lower relative abundance of the butyrate producing Faecalibacterium in patients with psychiatric disorders. All three increased genera were associated with higher symptom severity. Confounders, such as medication use and life style have not been accounted for. So far, the results of probiotics trials have been inconsistent. Most traditional and widely used probiotics (consisting of Bifidobacterium spp. and Lactobacillus spp.) are safe, however, they do not correct potential microbiota disbalances in these disorders. Findings on prebiotics and faecal microbiota transplantation (FMT) are too limited to draw definitive conclusions. Disease-specific pro/prebiotic treatment or even FMT could be auspicious interventions for prevention and therapy for psychiatric disorders and should be investigated in future trials.

show abstract

Section: Actinobacteriamentioning

confidence: 60%

Section: Gm In Three Major Psychiatric Disordersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of the gut microbiome in three major psychiatric disorders

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This suggests that the formation of adaptive immune responses against microbiota flagellins occurs very early in disease pathogenesis. Apart from the highly immunogenic properties of flagellins, bacterial flagella may facilitate transport across the epithelial mucus layer and enhance contact with a disrupted epithelial barrier, which may translate into an increased propensity to be exposed to the mucosal immune system ( 41 , 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera

et al. 2022

View full text Add to dashboard Cite

IntroductionInflammatory bowel disease (IBD) is characterized by a disturbed gut microbiota composition. Patients with IBD have both elevated mucosal and serum levels of IgG-antibodies directed against bacterial antigens, including flagellins. In this study, we aimed to determine to which intestinal bacteria the humoral immune response is directed to in patients with IBD.MethodsFecal and serum samples were collected from patients with IBD (n=55) and age- and sex-matched healthy controls (n=55). Fecal samples were incubated with autologous serum and IgG-coated fractions were isolated by magnetic-activated cell sorting (MACS) and its efficiency was assessed by flow cytometry. The bacterial composition of both untreated and IgG-coated fecal samples was determined by 16S rRNA-gene Illumina sequencing.ResultsIgG-coated fecal samples were characterized by significantly lower microbial diversity compared to the fecal microbiome. Both in patients with IBD and controls, serum IgG responses were primarily directed to Streptococcus, Lactobacillus, Lactococcus, Enterococcus, Veillonella and Enterobacteriaceae, as well as against specific Lachnospiraceae bacteria, including Coprococcus and Dorea (all P<0.001), and to Ruminococcus gnavus-like bacteria (P<0.05). In contrast, serological IgG responses against typical commensal, anaerobic and colonic microbial species were rather low, e.g. to the Lachnospiraceae members Roseburia and Blautia, to Faecalibacterium, as well as to Bacteroides. Patients with IBD showed more IgG-coating of Streptococcus, Lactobacillus, and Lactococcus bacteria compared to healthy controls (all P<0.05). No differences in IgG-coated bacterial fractions were observed between Crohn’s disease and ulcerative colitis, between active or non-active disease, nor between different disease locations.ConclusionThe IgG immune response is specifically targeted at distinct intestinal bacterial genera that are typically associated with the small intestinal microbiota, whereas responses against more colonic-type commensals are lower, which was particularly the case for patients with IBD. These findings may be indicative of a strong immunological exposure to potentially pathogenic intestinal bacteria in concordance with relative immune tolerance against commensal bacteria.

show abstract

“…Recently, an increasing amount of research has revealed that animal social behaviors (e.g., grooming, cuddling, mating, and other social contacts) also shape the gut microbiome community (Ezenwa et al, 2012; Li et al, 2021; Moeller et al, 2016; Nagpal & Cryan, 2021; Tung et al, 2015; Xia et al, 2022; Zhu et al, 2020). Environment (e.g., shared household or cohabitating) has a profound role in shaping animal gut microbiome (Gacesa et al, 2022; Rothschild et al, 2018; Song et al, 2013). Animals exhibit many kinds of behavior in addition to the behaviors necessary to survive and reproduce.…”

Section: Introductionmentioning

confidence: 99%

New challenges in the study of the evolution of wild animals and their gut microbiome

Zhu

2022

Ecology and Evolution

View full text Add to dashboard Cite

In this viewpoint, by reviewing the recent findings on wild animals and their gut microbiomes, we found some potential new insights and challenges in the study of the evolution of wild animals and their gut microbiome. We suggested that wild animal gut microbiomes may come from microbiomes in the animals' living habitats along with animals' special behavior, and that the study of long‐term changes in gut microbiomes should consider both habitat and special behaviors. Also, host behavior would facilitate the gut microbiome transmission between individuals. We suggested that research should integrate the evolutionary history and physiological systems of wild animals to understand the evolution of animals and their gut microbiomes. Finally, we proposed the Noncultured‐Cultured‐Fermentation‐Model Animal pipeline to determine the function (diet digestion, physiology, and behavior) of these target strains in the wild animal gut.

show abstract

Environmental factors shaping the gut microbiome in a Dutch population

Cited by 392 publications

References 78 publications

Role of the gut microbiome in three major psychiatric disorders

Role of the gut microbiome in three major psychiatric disorders

Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera

New challenges in the study of the evolution of wild animals and their gut microbiome

Contact Info

Product

Resources

About