1990
DOI: 10.1021/jf00093a064
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Environmental fate of ceftiofur sodium, a cephalosporin antibiotic. Role of animal excreta in its decomposition

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Cited by 81 publications
(54 citation statements)
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“…Zuccato et al [8] carried out an extensive investigation on the presence of drugs in drinking and surface waters also in the Lombardy region of Italy. Transformation of antibiotics [7,[9][10][11] has been widely studied. At present only for few pharmaceutical substances (aspirin, caffeine, clofibrate, ciclofosphamide, oestrogens, ibuprofen, naproxen) literature information on the biodegradability are available [7,[12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…Zuccato et al [8] carried out an extensive investigation on the presence of drugs in drinking and surface waters also in the Lombardy region of Italy. Transformation of antibiotics [7,[9][10][11] has been widely studied. At present only for few pharmaceutical substances (aspirin, caffeine, clofibrate, ciclofosphamide, oestrogens, ibuprofen, naproxen) literature information on the biodegradability are available [7,[12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…After injection, ceftiofur is rapidly metabolized by kidney and liver esterases to desfuroylceftiofur, which allows it to be conjugated to cysteine and glutathione (33). Some observations suggest that primary metabolites of these polar conjugates may be rapidly degraded further by viable intestinal microbes to inactive metabolites, since fecal slurries from cattle rapidly degrade ceftiofur, but steam-sterilized fecal slurries do not (17). Metabolites of ceftiofur are predominantly eliminated in the urine (26).…”
mentioning
confidence: 99%
“…In one study, the chemically unrelated antimicrobial drug tylosin was shown to be degraded by bovine fecal microbes with a half-life of 6.2 days (44). The half-life of ceftiofur in feces of cattle was too rapid to measure, and addition of feces to urine containing ceftiofur decreased the half-life from 23 to 17 h, indicating that a fecal component catalyzed degradation of the drug (17).…”
mentioning
confidence: 99%
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