Environmental health attitudes and behaviors: findings from a large pregnancy cohort study

Barrett, Emily S.; Sathyanarayana, Sheela; Janssen, Sarah; Redmon, J. Bruce; Nguyen, Ruby H.N.; Kobrosly, Roni W.; Swan, Shanna H.

doi:10.1016/j.ejogrb.2014.02.029

Cited by 91 publications

(86 citation statements)

References 31 publications

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“…However, the feasibility of adopting these practices in the general population should be carefully considered since environmental health-related behaviors have been found to vary in relation to sociodemographic factors [22]. …”

Section: Discussionmentioning

confidence: 99%

Dietary Phthalate Exposure in Pregnant Women and the Impact of Consumer Practices

Serrano

Karr

Seixas

et al. 2014

IJERPH

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Phthalates are ubiquitous endocrine-disrupting chemicals that are contaminants in food and contribute to significant dietary exposures. We examined associations between reported consumption of specific foods and beverages and first trimester urinary phthalate metabolite concentrations in 656 pregnant women within a multicenter cohort study, The Infant Development and Environment Study (TIDES), using multivariate regression analysis. We also examined whether reported use of ecofriendly and chemical-free products was associated with lower phthalate biomarker levels in comparison to not following such practices. Consumption of one additional serving of dairy per week was associated with decreases of 1% in the sum of di-2-ethylhexyl phthalate (DEHP) metabolite levels (95% CI: −2.0, −0.2). Further, participants who reported sometimes eating homegrown food had monoisobutyl phthalate (MiBP) levels that were 16.6% lower (95% CI: −29.5, −1.3) in comparison to participants in the rarely/never category. In contrast to rarely/never eating frozen fruits and vegetables, participants who reported sometimes following this practice had monobenzyl phthalate (MBzP) levels that were 21% higher (95% CI: 3.3, 41.7) than rarely/ever respondents. Future study on prenatal dietary phthalate exposure and the role of consumer product choices in reducing such exposure is needed.

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Section: Discussionmentioning

confidence: 99%

Dietary Phthalate Exposure in Pregnant Women and the Impact of Consumer Practices

Serrano

Karr

Seixas

et al. 2014

IJERPH

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“…2014 [13]. Briefly, TIDES recruited pregnant mothers and their children from four study centers from 2010 to 2012.…”

Section: Methodsmentioning

confidence: 99%

Anogenital distance and penile width measurements in The Infant Development and the Environment Study (TIDES): Methods and predictors

Sathyanarayana

Grady²,

Redmon

et al. 2015

Journal of Pediatric Urology

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Summary Background Anogenital distance (AGD), the distance from anus to genitals, is a sexually dimorphic measurement that has long been used to determine the sex of newborn rodent pups. Numerous animal studies have identified AGD as an androgen-sensitive endpoint, with a shortened distance in male offspring reflecting decreased androgen exposure in utero, and a longer distance in females reflecting increased androgen exposure in utero. Because AGD is a continuous measurement that can be assessed in all infants and adults, it can be included in epidemiologic studies as a predictive marker of reproductive health. We describe development of standardized measurement methods and predictors of AGD outcomes. Objectives One objective of this study was to develop a standardized protocol to measure anogenital distance (AGD) in newborns that would result in reliable and reproducible results. The second was to determine population statistics, demographics, and maternal predictors for AGD. We hypothesized that with proper training and oversight, our AGD measurement protocol would provide reliable and reproducible results. Methods We examined infants born to 758 participants in The Infant Development and the Environment Study (TIDES) enrolled in four clinical centers from 2011-2013. We developed and implemented a detailed training protocol incorporating multiple quality control (QC) measures. In males, we measured anoscrotal distance (AGDAS), anopenile distance (AGDAP), and penile width (PW) and in females, anofourchette distance (AGDAF,) and anoclitoral distance (AGDAC). A single examiner obtained three repetitions of all measurements, and a second examiner obtained independent measurements for 10% of infants. We assessed within-examiner variability and between-examiner variability. Results In the full TIDES cohort, including 758 mothers and children, significant predictors of AGD and PW included: age at exam, gestational age at birth, weight-for-length Z-score, maternal age and study center. In 371 males, the mean (SD) AGDAS, AGDAP, and PW were 24.7 (4.5), 49.6 (5.9), and 10.8 (1.3) mm, respectively. In 387 females, the mean (SD) AGDAF and AGDAC were 16.0 (3.2) mm and 36.7 (3.8) mm, respectively. The intra-examiner and inter-examiner intraclass coefficients averaged over all subjects and examiners were between 0.89-0.92 and 0.69-0.84 respectively. Discussion We have sent training videos or conducted in-person training and shared protocols with six research groups. As more research groups perform these measurements, we hope this sharing of methods will allow for the comparison of measurements across studies. Conclusions Our study demonstrates that with appropriate training and quality control measures, AGD and PW measurements can be performed reliably and in an easily replicable manner. These measurements should be adjusted for appropriate covariates in epidemiologic analysis.

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“…Details of participant recruitment in The Infant Development and the Environment Study (TIDES) cohort have been published elsewhere (40) and are summarized here briefly. TIDES recruited mothers in their first trimester (T1) at four clinical centers (University of California, San Francisco, University of Minnesota, University of Rochester Medical Center, and Seattle Children's Hospital/University of Washington) from 2010 to 2012.…”

Section: Study Participantsmentioning

confidence: 99%

Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

Sathyanarayana

Butts

Wang

et al. 2017

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context: Adequate sex steroid hormone concentrations are essential for normal fetal genital development in early pregnancy. Our previous study demonstrated an inverse relationship between third-trimester di-2-ethyl hexyl phthalate exposure and total testosterone (TT) concentrations. Here, we examine earlypregnancy phthalates, sex steroid hormone concentrations, and newborn reproductive outcomes. Design:We examined associations between urinary phthalate metabolite concentrations in early pregnancy and serum free testosterone (FT), TT, estrone (E1), and estradiol (E2) in 591 woman/infant dyads in The Infant Development and Environment Study; we also examined relationships between hormones and newborn genital outcomes using multiple regression models with covariate adjustment.Results: E1 and E2 concentrations were 15% to 30% higher in relation to 1-unit increases in log monoisobutyl phthalate (MiBP), mono-2-ethyl hexyl phthalate, and mono-2-ethyl-5-oxy-hexyl phthalate concentrations, and E2 was 15% higher in relation to increased log monobenzyl phthalate (MBzP). FT concentrations were 12% lower in relation to 1-unit increases in log mono(carboxynonyl) phthalate (MCNP) and mono-2-ethyl-5-carboxypentyl phthalate concentrations. Higher maternal FT was associated with a 25% lower prevalence of having a male genital abnormality at birth. Conclusions:The positive relationships between MiBP, MBzP, and DEHP metabolites and E1/E2 are unique and suggest a positive estrogenic effect in early pregnancy. The inverse relationship between MCNP and DEHP metabolites and serum FT supports previous work examining phthalate/testosterone relationships later in pregnancy. Higher FT in relation to a 25% lower prevalence of male genital abnormalities confirms the importance of testosterone in early fetal development. Abbreviations: AGD, anogenital distance; AGD AC , anoclitoral distance; AGD AF , anofourchette distance; AGD AP , anopenile distance; AGD AS , anoscrotal distance; BBzP, benzyl butyl phthalate; CDC, Centers for Disease Control and Prevention; CI, confidence interval; DBP, dibutyl phthalate; DEHP, di-2-ethyl hexyl phthalate; EDC, endocrine-disrupting chemical; FT, free testosterone; HPLC, high-performance liquid chromatography; LC, liquid chromatography; LOD, limit of detection; MBP, monobutyl phthalate; MBzP, monobenzyl phthalate; MCNP, mono(carboxynonyl) phthalate; MCOP, mono(carboxy-isooctyl) phthalate; MECPP, mono-2-ethyl-5-carboxypentyl phthalate; MEHP, mono-2-ethylhexyl phthalate; MEHHP, mono-2-ethyl-5-hydroxy-hexyl phthalate; MEOHP, mono-2-ethyl-5-oxy-hexyl phthalate; MEP, monoethyl phthalate; MiBP, monoisobutyl phthalate; MS/MS, tandem mass spectrometry; SD, standard deviation; SHBG, sex hormone-binding globulin; TIDES, The Infant Development and the Environment Study; TT, total testosterone. 1870https://academic.oup.com/jcem

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Environmental health attitudes and behaviors: findings from a large pregnancy cohort study

Cited by 91 publications

References 31 publications

Dietary Phthalate Exposure in Pregnant Women and the Impact of Consumer Practices

Dietary Phthalate Exposure in Pregnant Women and the Impact of Consumer Practices

Anogenital distance and penile width measurements in The Infant Development and the Environment Study (TIDES): Methods and predictors

Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

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