Environmental Influences on Body Weight and Behavior in Developing Rats After Neonatal 6-Hydroxydopamine

Pearson, DE; Mh, Teicher; Shaywitz, B. A.; Dj, Cohen; Young, Justin G.; Gm, Anderson

doi:10.1126/science.7394533

Cited by 40 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is noteworthy in this regard that PD35 rats were prepuber tal while PD56 rats were postpubertal (Baker 1979) Another possible explanation for our &ndings, that of delayed secondary neurodegenerative changes, can not be excluded. This possibility has been proposed to explain results of other studies that found changes in the expression of a neonatal lesion over time (Pearson et al 1980;Saji and Reis 1987). However, there is a very important difference between our study and these ear lier reports.…”

Section: Discussioncontrasting

confidence: 41%

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

Lipska¹,

Jaskiw²,

Weinberger³

1993

Neuropsychopharmacol

656

451

View full text Add to dashboard Cite

The constellation of major phenomena associated with schizophrenia (e.g., postpubertal onset, congenital hippocampal area damage, cortical functional deficits, limbic dopamine (DA) dysregulation, and vulnerability to stress) have been difficult to explain with a unitary animal model. Although it has been shown that rats develop increased mesolimbic DA transmission and reduced cortical DA turnover following adult excitotoxic lesions of the ventral hippocampus (VH), the implications of early developmental VH lesions are not known. To determine the developmental sequelae of such changes, we produced ibotenic acid lesions of the ventral hippocampal formation in rats on the 7th day after birth (PD7). Motor activity in a novel environment, after saline injection and after d-amphetamine administration were similar in control and lesioned rats at PD35. However, in early adulthood, at PD56, animals with the hippocampal lesion were hyperactive in each of these conditions. The emergence of the hyperactivity at PD56 could be prevented by pretr�atment with haloperidol. Moreover, rats lesioned as nlion.(tes, in contrast to a similar lesion induced in adult animals, were also hyperresponsive to stress evaluated with a swim test. This latter effect is analogous to that seen after adult lesions of the medial prefrontal cortex, rather than after adult lesions of VH, suggesting that the neonatal VH lesion may affect functional development of the medial prefrontal cortex. These results demonstrate that in rats with neonatally induced excitotoxic VH lesions, behavioral indices consistent with increased mesolimbic DA responsivity to stressful and to pharmacologic stimuli emerge only in early adulthood. Homologous mechanisms may underlie certain aspects of the pathophysiology of schizophrenia. fNeuropsychopharmacology 9:67-75, 1993J

show abstract

Section: Discussioncontrasting

confidence: 41%

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

Lipska¹,

Jaskiw²,

Weinberger³

1993

Neuropsychopharmacol

656

451

View full text Add to dashboard Cite

show abstract

“…Previous research has shown that control pups are seriously affected as a consequence of rearing in litters with manipulated pups. 10 It is conceivable that the repeated isolation paradigm exerted a highly disruptive effect on the dam that was translated to both groups of pups. Clinically, research has shown that it is the caregiver's response after a significant separation that is the critical variable in determining any enduring effects.…”

mentioning

confidence: 99%

Enduring Neurochemical Effects of Early Maternal Separation on Limbic Structures

Andersen¹,

Lyss²,

Dumont³

et al. 1999

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

“…In a previous study (Pearson et al, 1980), we noted that pups reared under conditions where half were vehicle and half 6-OHDA treated were considerably less active than pups reared in litters composed of all normal littermates. We would speculate that those vehicle pups reared under conditions where half their littermates had been affected by the neurotoxin, but only 3 other pups were normal, would be at a decided competitive advantage for food, and would tend to be less active than when having to compete with 7 normal littermates.…”

Section: Discussionmentioning

confidence: 95%

“…Recent experiments in our laboratory indicate that these dopanline-depleted pups are remarkably sensitive to environmental manipulations (Pearson, Teicher, Shaywitz, Cohen, Young, & Anderson, 1980;Teicher et al, 1981). Thus, 6-OHDA pups reared only with other 6-OHDA animals are more active than similarly depleted pups who are reared with normal animals.…”

mentioning

confidence: 96%

“…Most interestingly, avoidance performance was significantly affected in 6-OHDA animals reared with others treated sinularly. For example, while both 6-OHDA-treated groups required significantly longer than controls to escape from a shock, or learn an avoidance task, pups reared with other damaged animals were significantly impaired compared to 6-OHDA pups reared with normal pups (Pearson et al, 1980).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Environmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated with 6‐hydroxydopamine

Goldenring¹,

Shaywitz

Wool³

et al. 1982

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

In order to examine the impact of social environment on the development of motor activity and cognitive performance in rat pups treated with 6‐hydroxydopamine (6‐OHDA), we employed artificial rearing techniques pioneered by Hall. In contrast to 6‐OHDA‐treated mother‐reared pups which exhibit an increase in activity during their first postnatal month, 6‐OHDA‐treated artificially reared animals fail to demonstrate this hyperactivity. The absence of hyperactivity in 6‐OHDA‐treated artificially reared pups may reflect the absence of isolation‐induced motor activity at the beginning of the test period. Both mother‐reared and artificially reared 6‐OHDA pups demonstrated impairment in shock escape and shock avoidance, suggesting that these deficits in maze performance were influenced by an inherent biological lesion following 6‐OHDA treatment while motor activity may depend, to a considerable extent, on environmental manipulations.

show abstract

Environmental Influences on Body Weight and Behavior in Developing Rats After Neonatal 6-Hydroxydopamine

Cited by 40 publications

References 25 publications

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

Enduring Neurochemical Effects of Early Maternal Separation on Limbic Structures

Environmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated with 6‐hydroxydopamine

Contact Info

Product

Resources

About