Insulation materials are essential for minimizing energy use, enhancing thermal comfort, and minimizing greenhouse gas emissions in buildings. However, the insulation materials sector may have a considerable environmental impact. Many literature reviews and numerous studies have addressed the insulation material and its thickness from the perspectives of energy efficiency and thermal performance inside buildings, regardless of the environmental impacts of the insulation materials industry. Therefore, the research problem in this article is to observe the environmental burdens of the insulation materials industry. The scientific methodology used in the research is the life cycle assessment (LCA) methodology based on the ISO14040 series standards. Using the LCA approach, the research compares the environmental impact of four widely used insulation materials: extruded polystyrene, expanded polystyrene, rock wool, and glass wool. Without considering the use and end-of-life disposal stages (the system boundary of this study), the LCA approach assesses the insulation materials from the cradle to the gate, including raw material extraction, production, and transportation. The study analyzes the Ibny Baitak project in New Assiut City as a case study to apply the LCA of the insulation materials scenario. Extruded polystyrene, rock wool, and glass wool have the lowest impacts, according to the study's findings, while expanded polystyrene is the most harmful. Concerning the midpoint result, the XPS recorded 4.35 kgCO 2 eq, and the EPS pointed to 3.96 kgCO 2 eq. As for the endpoint result, the XPS insulation material has recorded the highest adverse impact compared to other materials by 1.61 mt. The EPS came in the second rank by 1.24 mt, then the rock wool by 0.55 mt, and finally, the glass wool by 0.33 mt. The results imply that a building's environmental effect over its lifetime can be considerably impacted by the material used for insulation. The study's findings can help architects, engineers, and construction professionals choose the best insulation for energy-efficient buildings. Considering the LCA approach is very important to consider in all manufactured materials. Thus, the industry and stakeholders should consider environmental concerns besides energy efficiency when choosing insulation materials for construction projects.