Environmental management in the gut: fecal transplantation to restore the intestinal ecosystem

Young, Vincent B.; Hayden, Mary K.

doi:10.1080/23744235.2016.1177200

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…Another approach to restoring the intestinal ecosystem is FMT, also called bacteriotherapy, a transfer of liquid filtrate feces from a healthy donor into the recipients’ gastrointestinal tract to treat a particular disease or condition [ 149 ]. Initially, bacteriotherapy was developed as an effective method of treating Clostridium difficile infection, which is a major cause of healthcare-associated diarrhea through perturbation of the normal GM [ 150 ].…”

Section: Gut Microbiota Age-related Changes Brain Functions and Neurmentioning

confidence: 99%

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro

Ostan

Candela

et al. 2017

Cell. Mol. Life Sci.

199

103

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The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which contributes to a variety of physiological functions. The GM is highly dynamic, being sensitive to environmental stimuli, and its composition changes over the host’s entire lifespan. However, the basic question of how much these changes may be ascribed to variables such as population, diet, genetics and gender, and/or to the aging process per se is still largely unanswered. We argue that comparison among studies on centenarians—the best model of healthy aging and longevity—recruited from different geographical areas/populations (different genetics and dietary habits) can help to disentangle the contribution of aging and non-aging-related variables to GM remodeling with age. The current review focuses on the role of population, gender and host genetics as possible drivers of GM modification along the human aging process. The feedback impact of age-associated GM variation on the GM–brain axis and GM metabolomics is also discussed. We likewise address the role of GM in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, and its possible therapeutic use, taking advantage of the fact that centenarians are characterized by an extreme (healthy) phenotype versus patients suffering from age-related pathologies. Finally, it is argued that longitudinal studies combining metagenomics sequencing and in-depth phylogenetic analysis with a comprehensive phenotypic characterization of centenarians and patients using up-to-date omics (metabolomics, transcriptomics and meta-transcriptomics) are urgently needed.

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Section: Gut Microbiota Age-related Changes Brain Functions and Neurmentioning

confidence: 99%

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro

Ostan

Candela

et al. 2017

Cell. Mol. Life Sci.

199

103

View full text Add to dashboard Cite

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“…Intestinal inflammation can be mitigated by reshaping gut microbiota [73], which enhances the intestinal health of poultry [74]. Presently, dietary interventions and probiotic supplementation are regarded as essential to alter the gut microbiota, and FMT has got considerable attention to reshape the host intestinal microbiota via assessing the microbe-host signal profile for improving human and chicken health [19,75,76]. Lactobacillus and Bifidobacterium are the potential probiotics that prominently influence the chicken microbial abundance [46], and Yang et al [69] demonstrated that supplementation of Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 99%

Chicken jejunal microbiota improves growth performance by mitigating intestinal inflammation

et al. 2022

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Background Intestinal inflammation is prevalent in chicken, which results in decreased growth performance and considerable economic losses. Accumulated findings established the close relationship between gut microbiota and chicken growth performance. However, whether gut microbiota impacts chicken growth performance by lessening intestinal inflammation remains elusive. Results Seven-weeks-old male and female chickens with the highest or lowest body weights were significantly different in breast and leg muscle indices and average cross-sectional area of muscle cells. 16S rRNA gene sequencing indicated Gram-positive bacteria, such as Lactobacilli, were the predominant species in high body weight chickens. Conversely, Gram-negative bacteria, such as Comamonas, Acinetobacter, Brucella, Escherichia-Shigella, Thermus, Undibacterium, and Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium were significantly abundant in low body weight chickens. Serum lipopolysaccharide (LPS) level was significantly higher in low body weight chickens (101.58 ± 5.78 ng/mL) compared with high body weight chickens (85.12 ± 4.79 ng/mL). The expression of TLR4, NF-κB, MyD88, and related inflammatory cytokines in the jejunum was significantly upregulated in low body weight chickens, which led to the damage of gut barrier integrity. Furthermore, transferring fecal microbiota from adult chickens with high body weight into 1-day-old chicks reshaped the jejunal microbiota, mitigated inflammatory response, and improved chicken growth performance. Conclusions Our findings suggested that jejunal microbiota could affect chicken growth performance by mitigating intestinal inflammation.

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“…The probiotic Lactobacillus rhamnosus GG ATCC 53103 has been shown to promote the anti-inflammatory pathways of resident microorganisms [73]. Fecal microbiota transplantation (FMT) is a radical management program that is used to restore the intestinal ecosystem through the transferring of liquid filtrate feces from a healthy donor into the recipient’s gastrointestinal tract [74]. FMT has been used as a therapeutic option for Clostridium difficile infection [75].…”

Section: Gut Microbiotamentioning

confidence: 99%

Recent Advances in Anti-Aging Medicine

2019

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A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging process and its associated effects, such as disability and frailty. Anti-aging medicine is emerging as a growing industry, but many supplements or protocols are available that do not have scientific evidence to support their claims. In this review, the mechanisms of action and the clinical implications of anti-aging interventions were examined and explained. Calorie restriction mimetics define compounds that imitate the outcome of calorie restriction, including an activator of AMP protein kinase (metformin), inhibitor of growth hormone/insulin-like growth factor-1 axis (pegvisomant), inhibitor of mammalian target of rapamycin (rapamycin), and activator of the sirtuin pathway (resveratrol). Hormonal replacement has also been widely used in the elderly population to improve their quality of life. Manipulating healthy gut microbiota through prebiotic/probiotics or fecal microbiota transplantation has significant potential in anti-aging medicine. Vitamin D is expected to be a primary anti-aging medicine in the near future due to its numerous positive effects in the elderly population.

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Environmental management in the gut: fecal transplantation to restore the intestinal ecosystem

Cited by 11 publications

References 18 publications

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Chicken jejunal microbiota improves growth performance by mitigating intestinal inflammation

Recent Advances in Anti-Aging Medicine

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