Environmental Pathology

Centeno, José A.; Mullick, Florabel G.; Ishak, Kamal G.; Franks, Teri J.; Burke, Allen; Koss, Michael N.; Perl, Daniel P.; Tchounwou, Paul B.; Pestaner, Joseph P.

doi:10.1007/978-94-007-4375-5_25

Cited by 15 publications

(11 citation statements)

References 165 publications

(122 reference statements)

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“…Historically, it arose as a result of the observation of geographical differences in disease distribution (Peeters 1987). Medical geology is currently undergoing a qualitative change due to the interaction among scientist from different disciplines, and in research opportunities to better understand how the natural environment impacts human health (Centeno et al 2013). …”

Section: Introductionmentioning

confidence: 99%

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Association between heavy metal and metalloid levels in topsoil and cancer mortality in Spain

Núñez

Fernández-Navarro

Martín-Méndez

et al. 2017

Environ Sci Pollut Res

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Spatio-temporal cancer mortality studies in Spain have revealed patterns for some tumours which display a distribution that is similar across the sexes and persists over time. Such characteristics would be common to tumours that shared risk factors, including the geochemical composition of the soil. The aim of this study was to assess the possible association between heavy metal and metalloid levels in topsoil (upper soil horizon) and cancer mortality in mainland Spain. Ecological cancer mortality study at a municipal level, covering 861,440 cancer deaths (27 different tumour locations) in 7917 Spanish mainland towns, from 1999 to 2008. The elements included in this analysis were Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn. Topsoil levels (partial extraction) were determined by ICP-MS at 13,317 sampling points. For the analysis, the data on the topsoil composition have been transformed by the centred logratio (clr-transformation). Principal factor analysis was performed to obtain independent latent factors for the transformed variables. To estimate the effect of heavy metal levels in topsoil composition on mortality, we fitted Besag, York and Mollié models, which included each town’s factor scores as the explanatory variable. Integrated Nested Laplace Approximation (INLA) was used as a tool for Bayesian inference. All results were adjusted for sociodemographic variables. The results showed an association between trace contents of heavy metals and metalloids in topsoil and mortality due to tumours of the digestive system in mainland Spain. This association was observed in both sexes, something that would support the hypothesis that the incorporation of heavy metals into the trophic chain might be playing a role in the aetiology of some types of cancer. Topsoil composition and the presence of potentially toxic elements in trace concentrations might be an additional component in the aetiology of some types of cancer, and go some way to determine the ensuing geographic differences in mortality in Spain. The results support the interest of inclusion of heavy metal levels in topsoil as a hypothesis in analytical epidemiological studies using biological markers of exposure to heavy metals and metalloids.Electronic supplementary materialThe online version of this article (doi:10.1007/s11356-017-8418-6) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

“…Exposure to arsenic and heavy metals is associated with various types of cancer, but there is far less information on the health effects of low-dose chronic exposure to many trace metals (Naujokas et al 2013) (Centeno et al 2013). Studies on the health effects of metals in topsoil belong to this latter category.…”

Section: Introductionmentioning

confidence: 99%

Association between heavy metal and metalloid levels in topsoil and cancer mortality in Spain

Núñez

Fernández-Navarro

Martín-Méndez

et al. 2017

Environ Sci Pollut Res

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“…Actual health effects are contingent on whether TEs can be accessed and assimilated biologically (Menefee and Hettariachchi, 2018). TE contamination sensitivity also varies considerably between as well as within species, so that multiple safety levels are formulated according to specific situations or questions (Brown et al, 2016: 28;Centeno et al, 2005;McLaughlin et al, 2011: 13-14;Morgan, 2016: 73). The recalcitrance and therefore cumulative nature of TE contamination makes for the sort of problem that is not resolvable except by containment and prevention.…”

Section: Situating Te Contamination Baselinesmentioning

confidence: 99%

The troubling and troublesome worlds of urban soil trace element contamination baselines

Mauro

2019

Environment and Planning E: Nature and Space

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“…Downstream of their confluence, and in the vicinity of Lagos, drinking water exceeds the WHO quality standards for Mn and, to a lesser extent, Al. Manganese is neurotoxic and can provoke Parkinson's disease (Centeno et al 2005).…”

Section: Resultsmentioning

confidence: 99%

Quality of water resources in the Niger basin and in the region of Lagos (Nigeria)

Adeaga

Mahé

Dieulin

et al. 2017

Bulletin of Geography. Physical Geography Series

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Abstract. Water quality studies in Nigeria are usually conducted at local scales and limited to a restricted number of chemical contaminants, while reliable data on trace metal concentrations (including arsenic) are relatively scarce. This study focuses on the quality of available renewable water resources in terms of major ion and trace element concentrations at selected sampling locations in the Lower River Niger basin and part of the Lagos region. A screening of water contamination by arsenic and heavy metals was carried out through water sampling at selected locations using in situ measurement and laboratory testing to estimate heavy metal concentrations and water type. The analysis reveals moderate trace element contamination of the water resources, with the exception of Pb, while Mn and, to a lesser extent, Al exceeded WHO quality standards, but the Arsenic concentrations are within drinking water quality standards and are safe for consumption and irrigation, while the water type is Bicarbonate.

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Environmental Pathology

Cited by 15 publications

References 165 publications

Association between heavy metal and metalloid levels in topsoil and cancer mortality in Spain

Association between heavy metal and metalloid levels in topsoil and cancer mortality in Spain

The troubling and troublesome worlds of urban soil trace element contamination baselines

Quality of water resources in the Niger basin and in the region of Lagos (Nigeria)

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