This article reviews interdisciplinary toxicity literature, building from Gerald E. Markowitz and David Rosner’s “deceit and denial” and Phil Brown’s “contested illnesses” to argue for a third, more critical analytic that I term “empire and empirics.” Deceit and denial pit corporate actors against antitoxins advocates, while contested illnesses highlight social movements. Empire and empirics center the role of imperialism in reproducing today’s unevenly distributed toxic exposures. I find this third path the most generative because the products and the production of science—toxicants and toxicology—are situated in their sociohistorical, politico-economic, ecological, and affective contexts. Revealing the imperialist logics embedded into dominant ontoepistemology also illuminates alternative, liberatory pathways toward more environmentally just futures. I close with examples of “undisciplined” action research, highlighting scholar-practitioners who study toxicity with care and in nonhierarchical collaboration. While undisciplining is challenging, its potential for realizing environmental justice far outweighs the difficulties of doing science differently.