Environmental pollutants exposure: A potential contributor for aging and age-related diseases

Liu, Yaru; Wang, Jiequan; Huang, Zhenchi; Liang, Jun; Xia, Qingrong; Qin, Xia; Liu, Xinhua

doi:10.1016/j.etap.2020.103575

Cited by 29 publications

(11 citation statements)

References 139 publications

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“…Environmental pollutant exposure plays an important role in the acceleration of aging and the high morbidity and mortality rates of age-related diseases [ 12 ]. Thiocyanate, perchlorate, and nitrate are found ubiquitously in the environment, leading to broad human exposure and primary uptake through the food web, cigarette smoke, working in cyanide-related industries, and drinking water [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Association between environmental exposure to perchlorate, nitrate, and thiocyanate and serum α-Klotho levels among adults from the National Health and nutrition examination survey (2007–2014)

Yao

et al. 2022

BMC Geriatr

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Background & aims Aging is a pathophysiological process driven by a diverse set of complex biological processes, and environmental pollution plays an important role in this process. This study aimed to explore the association between serum α-Klotho levels and urinary perchlorate, nitrate, and thiocyanate levels. Methods This secondary dataset analysis included 4875 participants (mean age, 57.69 year; male, 49.58%; non-Hispanic White, 47.67%) from the US National Health and Nutrition Examination Survey (2007–2014). Enzyme-linked immunosorbent assay was used to quantify α-Klotho levels, and ion chromatography coupled with electrospray tandem mass spectrometry was used to quantify thiocyanate, nitrate, and perchlorate levels. Multivariate linear regression models were applied to estimate the association between perchlorate, nitrate, and thiocyanate levels and serum α-Klotho levels. Results Urinary thiocyanate levels were negatively associated with α-Klotho levels (β = − 0.006; 95% confidence interval, − 0.010 to − 0.003; P = 0.0004) after adjusting for age, sex, body mass index, race, alcohol consumption, estimated glomerular filtration rate, underlying disease, physical activity, smoking status, usual energy intake, and urinary creatinine and serum cotinine levels and mutual adjustment of urinary perchlorate, urinary nitrate, and urinary thiocyanate levels. The α-Klotho level in participants in the highest quartile was higher by 50.567 ng/mL (β = 50.567; 95% confidence interval, 14.407 to 86.726; P = 0.009) than that in participants in the lowest quartile of urinary perchlorate. A linear relationship was observed between urinary thiocyanate and α-Klotho levels. Conclusions Urinary thiocyanate levels were negatively associated with serum α-Klotho levels. Urinary thiocyanate should be further investigated as a potential mediator of aging and age-related diseases.

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Section: Introductionmentioning

confidence: 99%

Association between environmental exposure to perchlorate, nitrate, and thiocyanate and serum α-Klotho levels among adults from the National Health and nutrition examination survey (2007–2014)

Yao

et al. 2022

BMC Geriatr

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“…Epidemiological studies on humans show that exposure to PM does not only alter telomere dynamics in those tissues directly exposed to the stressor such as lung or skin cells, but also in peripheral blood and in the placenta (Liu et al, 2021). In addition, increases in telomere length have been reported in peripheral blood in response to short-term PM exposure, and although the mechanisms are not fully understood, these seem to be independent of telomerase expression via methylation on its promoter (Dioni et al, 2011).…”

Section: Air Pollutionmentioning

confidence: 99%

“…In light of the available epidemiological studies, exposure to POPs is generally associated with shorter telomeres (reviewed by Liu et al, 2021 ), although this may depend on the particular compound or exposure intensity (e.g., Callahan et al, 2017 ; Shin et al, 2010 ; Vriens et al, 2019 ). Metabolism of POPs can induce oxidative stress via the production of ROS as by‐products, and can also alter the mitochondrial redox status and function, such as via oxidative damage (Liu et al, 2020 ; Figure 2 ). Moreover, telomere dysfunction due to exposure to POPs may also be driven by reduced telomerase activity (e.g., Senthilkumar et al, 2011 ) or by the upregulation of TERRA (Yuan et al, 2018 ).…”

Section: Influence Of Anthropogenic Disturbances On Telomere Structur...mentioning

confidence: 99%

Telomeres and anthropogenic disturbances in wildlife: A systematic review and meta‐analysis

Salmón

Burraco

2022

Molecular Ecology

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Human-driven environmental changes are affecting wildlife across the globe. These challenges do not influence species or populations to the same extent and therefore a comprehensive evaluation of organismal health is needed to determine their ultimate impact. Evidence suggests that telomeres (the terminal chromosomal regions) are sensitive to environmental conditions and have been posited as a surrogate for animal health and fitness. Evaluation of their use in an applied ecological context is still scarce. Here, using information from molecular and occupational biomedical studies, we aim to provide ecologists and evolutionary biologists with an accessible synthesis of the links between human disturbances and telomere length. In addition, we perform a systematic review and meta-analysis on studies measuring telomere length in wild/wild-derived animals facing anthropogenic disturbances. Despite the relatively small number of studies to date, our meta-analysis revealed a significant small negative association between disturbances and telomere length (−0.092 [−0.153, −0.031]; n = 28; k = 159). Yet, our systematic review suggests that the use of telomeres as a biomarker to understand the anthropogenic impact on wildlife is limited. We propose some research avenues that will help to broadly evaluate their suitability: (i) further causal studies on the link between human disturbances and telomeres; (ii) investigating the organismal implications, in terms of fitness and performance, of a given telomere length in anthropogenically disturbed scenarios; and (iii) better understanding of the underlying mechanisms of telomere dynamics. Future studies in these facets will help to ultimately determine their role as markers of health and fitness in wildlife facing anthropogenic disturbances.

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“…Exposure to environmental pollutants and contaminants, such as air pollution, heavy metals, and pesticides, has been associated with increased risk for health problems, from hypertension, to respiratory and cardiovascular disease, to Alzheimer's disease, and depression (Brook et al., 2010; Manczak et al., 2020; Mir et al., 2020; Navas et al., 2007; Reuben et al., 2021). One mechanism that might underlie the association between pollutant exposure and disease is accelerated rates of biological aging, often measured by telomere length (Liu et al., 2021; Martens et al., 2017). Telomeres are protein caps located at the ends of chromosomes that protect the genome and serve as a marker of cellular aging (Blackburn, 2000).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal volume indexes neurobiological sensitivity to the effect of pollution burden on telomere length in adolescents

Miller

Buthmann

Gotlib

2022

New Drctns Chld & Adlscnt

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Exposure to environmental pollutants has been associated with cellular aging in children and adolescents. Individuals may vary, however, in their sensitivity or vulnerability to the effects of environmental pollutants. Larger hippocampal volume has emerged as a potential index of increased sensitivity to social contexts. In exploratory analyses (N = 214), we extend work in this area by providing evidence that larger hippocampal volume in early adolescence reflects increased sensitivity to the effect of neighborhood pollution burden on telomere length (standardized β = -0.40, 95% CI[-0.65, -0.15]). In contrast, smaller hippocampal volume appears to buffer this association (standardized β = 0.02). In youth with larger hippocampal volume, pollution burden was indirectly associated with shorter telomere length approximately 2 years later through shorter telomere length at baseline (indirect standardized β = -0.25, 95% CI[-0.40, 0.10]). For these youth, living in high or low pollutionburdened neighborhoods may predispose them to develop shorter or longer telomeres, respectively, later in adolescence.

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Environmental pollutants exposure: A potential contributor for aging and age-related diseases

Cited by 29 publications

References 139 publications

Association between environmental exposure to perchlorate, nitrate, and thiocyanate and serum α-Klotho levels among adults from the National Health and nutrition examination survey (2007–2014)

Association between environmental exposure to perchlorate, nitrate, and thiocyanate and serum α-Klotho levels among adults from the National Health and nutrition examination survey (2007–2014)

Telomeres and anthropogenic disturbances in wildlife: A systematic review and meta‐analysis

Hippocampal volume indexes neurobiological sensitivity to the effect of pollution burden on telomere length in adolescents

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