Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review

Scott, Jennifer; Hartnett, Jack; Mockler, David; Little, Mark A.

doi:10.1016/j.autrev.2020.102660

Cited by 39 publications

(28 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Environmental factors such as smoking, silica exposure, Staphylococcus aureus infection and use of drugs (e.g., propylthiouracil and hydralazine) are identified risk factors associated with the development of AAV [52,53].…”

Section: Pathogenesis Of Aav-ildmentioning

confidence: 99%

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review

Kadura

Raghu

2021

Eur Respir Rev

View full text Add to dashboard Cite

Over the past three decades, an increasing number of publications have reported the association between interstitial lung disease (ILD) and anti-neutrophil cytoplasmic antibody (ANCA) or ANCA-associated vasculitis (AAV). With this increased awareness, we have reviewed the literature to date and provide an update in this narrative review. The vast majority of cases of ILD have been shown to be in the setting of positive anti-myeloperoxidase antibody and can be present in up to 45% of patients of microscopic polyangiitis, though cases of ILD associated with proteinase 3 ANCA have rarely been reported. Pulmonary fibrosis and ANCA positivity can occur with or without systemic involvement. The pathogenetic mechanisms establishing the relationship between ANCA and the development of pulmonary fibrosis remain unclear. Histologic and radiographic features of ANCA-ILD most commonly reveal usual interstitial pneumonia or non-specific interstitial pneumonia patterns, though other atypical features such as bronchiolitis have been described. ILD in the setting of AAV has been associated with worse outcomes, and thus early identification and treatment in these patients is appropriate. We advocate that ANCA antibody testing be performed as a baseline evaluation in patients presenting with idiopathic interstitial pneumonia. Suggested treatment of ANCA-ILD includes immunosuppression and/or antifibrotic agents, though supporting data and clinical trials to substantiate use of these therapies are needed.

show abstract

Section: Pathogenesis Of Aav-ildmentioning

confidence: 99%

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review

Kadura

Raghu

2021

Eur Respir Rev

View full text Add to dashboard Cite

show abstract

“…Mainly, these occurred in individuals who were susceptible to autoimmune diseases and those in remission with these disorders. Therefore, an accepted hypothesis is that AAV develops in patients with a susceptible genetic background and a simultaneous exposure to environmental or other risk factors [ 11 ]. Previously, numerous reports have described a temporal association of AAV to influenza vaccination [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

ANCA-associated vasculitis following ChAdOx1 nCoV19 vaccination: case-based review

et al. 2022

View full text Add to dashboard Cite

For the foreseeable future, vaccines are the cornerstone in the global campaign against the Coronavirus Disease-19 (COVID-19) pandemic. As the number and fatalities due to COVID-19 decline and the lockdown anywise rescinded, we recognize an increase in the incidence of autoimmune disease post-COVID-19 vaccination. However, the causality of the most vaccine-induced side effects is debatable and, at best, limited to a temporal correlation. We herein report a case of a 51-year-old gentleman who developed Anti-Neutrophil Cytoplasmic Antibody (ANCA)-associated vasculitis (AAV) 2 week post-COVID-19 vaccination. The patient responded favorably to oral steroids and rituximab. Additionally, we conducted a case-based review of vaccine-associated AAV describing their clinical manifestations and treatment response of this emerging entity. Supplementary Information The online version contains supplementary material available at 10.1007/s00296-021-05069-x.

show abstract

“…In contrast, other risk factors for asthma (e.g., chemicals, metals, pesticides, and textile fibers) showed no effect on EGPA or even a protective effect (i.e., smoking) (37,40,41). Finally, agents such as silica, which is strongly associated with EGPA and AAV overall, do not seem to predispose to asthma in these patients (6–8,42). Further studies addressing differences in environmental exposures between asthma and EGPA may shed light on the different pathogenic mechanisms involved in these 2 conditions.…”

Section: Discussionmentioning

confidence: 99%

Occupational Exposures and Smoking in Eosinophilic Granulomatosis With Polyangiitis: A Case–Control Study

Maritati

Peyronel

Fenaroli

et al. 2021

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. Environmental agents and occupational exposures may confer susceptibility to EGPA, but data are scarce. This study was undertaken to investigate the association between occupational exposures (e.g., silica, farming, asbestos, and organic solvents) and other environmental agents (e.g., smoking) and the risk of EGPA. Methods Patients with newly diagnosed EGPA (n = 111) and general population controls (n = 333) who were matched for age, sex, and geographic area of origin were recruited at a national referral center for EGPA. Exposures were assessed using a dedicated questionnaire administered by a specialist in occupational medicine, under blinded conditions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results Exposures to silica (OR 2.79 [95% CI 1.55–5.01], P = 0.001), organic solvents (OR 3.19 [95% CI 1.91–5.34], P < 0.001), and farming (OR 2.71 [95% CI 1.71–4.29], P < 0.001) were associated with an increased risk of EGPA. Co‐exposure to silica and farming yielded an OR of 9.12 (95% CI 3.06–27.19, P < 0.001), suggesting a multiplicative effect between these 2 exposures. Smoking (current and former smokers combined) was significantly less frequent among patients with EGPA compared to controls (OR 0.49 [95% CI 0.29–0.70], P < 0.001). The pack‐year index was also lower among patients with EGPA (OR 0.96 [95% CI 0.94–0.98], P < 0.001). The association of silica and farming was primarily aligned with ANCA‐positive EGPA, while the association of smoking status and organic solvents was primarily aligned with ANCA‐negative EGPA. Conclusion The environment can influence susceptibility to EGPA. Exposure to silica, farming, or organic solvents is associated with an increased risk of EGPA, while smoking is associated with a lower risk. These exposures seem to have distinct effects on different EGPA subsets.

show abstract

Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review

Cited by 39 publications

References 112 publications

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review

ANCA-associated vasculitis following ChAdOx1 nCoV19 vaccination: case-based review

Occupational Exposures and Smoking in Eosinophilic Granulomatosis With Polyangiitis: A Case–Control Study

Contact Info

Product

Resources

About