Environmental RNA interference in animals

Meng, Lingfeng; Chen, Liang; Li, ZhaoYong; Wu, Zheng-Xing; Ge, Shengfang

doi:10.1007/s11434-013-5982-0

Cited by 5 publications

(3 citation statements)

References 88 publications

(126 reference statements)

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“…Cells are subjected to inner and outer stimuli and insults at all times, and noncoding RNAs are known to play vital roles in these contexts [23][24][25][26]. Further investigations are essential to better understand the involvement of noncoding RNAs in these biological events.…”

Section: Discussionmentioning

confidence: 99%

Altered expression of microRNAs in the response to ER stress

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Altered expression of microRNAs in the response to ER stress

et al. 2015

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“…Sid-1 expresses multi-pass transmembrane protein, conserved amongst nematodes to mammals, whilst sid-2 encodes a single-pass transmembrane protein found only in Caenorhabditis elegans and close species (Feinberg & Hunter, 2003;Jose et al, 2009;McEwan et al, 2012;Winston et al, 2002Winston et al, , 2007. Notably, to date, there is no consensus about the potential effect of external sRNAs on vertebrates and invertebrates, and reports are controversial (Akay et al, 2015;Chan & Snow, 2017;Liu et al, 2012;Meng et al, 2013;Petrick et al, 2015). First reports of the alteration of gene expression in invertebrates upon ingestion of dsRNA were on C. elegans.…”

Section: Off-target Effects and Health Concernsmentioning

confidence: 99%

Harnessing environmental‐RNAi to win an enduring battle: Plant versus pathogen

Almasi

Amari

2021

Journal of Phytopathology

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With increasing fear of GMOs and pesticide residues in agricultural products and the environment, alternative efficient, fast approaches are urgently needed for crop protection. After its first report in 2001, topical applications of dsRNA showed a great potential as a non-transgenic approach to counter plant pathogens and pests via RNA-silencing (Tenllado & Dıaz-Ruız, 2001). The advantages of RNAi, such as specificity and lack of the main GMO's drawback, public concerns, give topical RNAi great potential to become a future trend in environmental-friendly plant protection strategies.Several studies illustrated that one of the main ways of communication between the microbiome and their interacting partner(s) is by the RNA language. Such communication is a crucial determinant for the nature of the interaction, from parasitism to commensalism.Plants and pathogens continuously exchange small RNA (sRNA) molecules to alter gene expression at their opponent side, so-called process 'environmental-RNAi' or 'cross-kingdom RNAi' (Huang

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“…More recent research indicates that they might have an indirect effect through the biogenesis of secondary siRNAs . Figure based on (Jose and Hunter, 2007); ; (Rocheleau, 2012); , (Meng et al, 2013) and (Sarkies and Miska, 2014) Sid-1…”

Section: Cellular Uptake and Transport Of Srnas In Caenorhabditis Ele...mentioning

confidence: 99%

Literature review of baseline information on RNAi to support the environmental risk assessment of RNAi‐based GM plants

Christiaens

Dzhambazova

Kostov

et al. 2018

EFS3

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This report is the outcome of an EFSA procurement (OC/EFSA/GMO/2015/02) which aims at reviewing relevant scientific information on RNA interference (RNAi) that could serve as baseline information for the environmental risk assessment of RNAi‐based genetically modified (GM) plants. The report is based on a systematic literature search on the use of RNAi molecules in arthropods, nematodes, annelids and molluscs with dsRNA, siRNA and miRNA applied primarily through feeding and soaking (oral ingestion). The numbers of retrieved publications covering these areas are reported, along with the species name, life stages tested, the target gene and its function, details of the test substances and their concentrations used, methods of delivery and effects. Separate sections discuss the available information on: (1) the uptake and systematic spread of RNAi activity, including a description of the various components involved in this process; (2) the mechanisms of dsRNA‐, siRNA‐ and miRNA‐elicited gene silencing and the different factors involved in RNAi efficiency; (3) routes of exposure of the biotic and abiotic environment to dsRNA, siRNA and miRNA from GM plants; (4) the environmental fate of dsRNA, siRNA and miRNA; and (5) the various factors that may limit non‐target effects including exposure, factors influencing the silencing efficiency of dsRNA, siRNA and miRNA, possible unintended and off‐target effects, and their mechanisms. Finally, an overview of the species of arthropods, nematodes, annelids and molluscs for which genomic data are available is also presented. The report identifies some of the challenges involved in developing plants with RNAi systems which affect invertebrate gene expression. The report also concludes that, currently, knowledge on issues such as exposure, specificity, offtarget effects, sequence similarities and bioinformatics is very limited, as only a few RNAi expressing plants which specifically target invertebrate species have been developed and comprehensively studied.

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Environmental RNA interference in animals

Cited by 5 publications

References 88 publications

Altered expression of microRNAs in the response to ER stress

Altered expression of microRNAs in the response to ER stress

Harnessing environmental‐RNAi to win an enduring battle: Plant versus pathogen

Literature review of baseline information on RNAi to support the environmental risk assessment of RNAi‐based GM plants

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