Environmental tobacco smoke and peripheral arterial disease: A review

Ngu, Natalie L. Y.; McEvoy, Mark

doi:10.1016/j.atherosclerosis.2017.09.024

Cited by 17 publications

(14 citation statements)

References 50 publications

(86 reference statements)

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“…Meanwhile, compared with never smokers, current and former smokers with PAD had higher rates of death ( 37 ). High exposure to environmental tobacco also increased the risk of PAD among non-smokers ( 38 ). We found that the percentage contribution of tobacco use to age-standardized death of PAD was much larger in males than in females, which is consistent with the findings from Kumakura et al ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Burden of Peripheral Artery Disease and Its Attributable Risk Factors in 204 Countries and Territories From 1990 to 2019

Lin¹,

Chen²,

Jiang³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundData on burden of peripheral artery disease (PAD) and its attributable risk factors are valuable for policymaking. We aimed to estimate the burden and risk factors for PAD from 1990 to 2019.MethodsWe extracted the data on prevalence, incidence, death, years lived with disability (YLDs), and years of life lost (YLLs) from the Global Burden of Disease Study 2019 to measure PAD burden. Moreover, the attributable burden to PAD risk factors was also estimated.ResultsGlobally, in 2019, 113,443,017 people lived with PAD and 10,504,092 new cases occurred, resulting in 74,063 deaths, 500,893 YLDs, and 1,035,487 YLLs. The absolute numbers of PAD prevalent and incident cases significantly increased between 1990 and 2019, contrasting with the decline trends in age-standardized prevalence and incidence rates. However, no statistically significant changes were detected in the global age-standardized death or YLL rates. The burden of PAD and its temporal trends varied significantly by location, gender, age group, and social-demographic status. Among all potentially modifiable risk factors, age-standardized PAD deaths worldwide were primarily attributable to high fasting plasma glucose, followed by high systolic blood pressure, tobacco, kidney dysfunction, diet high in sodium, and lead exposure.ConclusionPAD remained a serious public health problem worldwide. More strategies aimed at implementing cost-effective interventions and addressing modifiable risk factors should be carried out, especially in regions with high or increasing burden.

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Section: Discussionmentioning

confidence: 99%

Burden of Peripheral Artery Disease and Its Attributable Risk Factors in 204 Countries and Territories From 1990 to 2019

Lin¹,

Chen²,

Jiang³

et al. 2022

Front. Cardiovasc. Med.

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“…Lo anterior está de acuerdo con el estudio UKPDS (30) en el que un buen control glucémico está asociado con disminución del riesgo de complicaciones macrovasculares; de igual manera una revisión sistemática y metaanálisis de la Universidad de Berna encontró que un mejor control glucémico en pacientes con DM1 y DM2 se asocia con una disminución de la incidencia de eventos macrovasculares especialmente EAP y accidentes cerebrovasculares (31). El consumo de cigarrillo estuvo presente en los pacientes con EAP, no se indagó por la intensidad ni duración del consumo pero se ha encontrado que la prevalencia e incidencia de EAP es mayor en pacientes con alto consumo de tabaco y tiempo prolongado de exposición (32)(33)(34)(35). La mayoría de los pacientes con EAP tenían un IMC > 25.…”

Section: Discussionunclassified

Enfermedad arterial periférica y estrés oxidativo en pacientes del programa para la prevención de complicaciones de diabetes mellitus y dislipidemias

et al. 2019

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Introducción. La enfermedad arterial periférica (EAP) es causada principalmente por aterosclerosis e intervienen la hiperglucemia y dislipidemia que desencadenan estrés oxidativo y daño vascular. Objetivo. Determinar la prevalencia de EAP en pacientes con diabetes mellitus tipo 2 (DM2) y/o prediabetes y/o dislipidemias, así como algunos factores de riesgo; también, establecer si los niveles urinarios de 8-isoprostano-f2α (marcador de estrés oxidativo) están elevados en pacientes con EAP. Diseño. Estudio de tipo transversal, no probabilístico, de conveniencia. Materiales y métodos. La muestra comprendió 146 pacientes con DM2 y/o prediabetes y/o dislipidemias. Se registraron factores de riesgo, síntomas relacionados con EAP, medida índice tobillo-brazo y variables bioquímicas (HbA1c%, glucemia basal, perfil lipídico, creatinina y albuminuria). Se determinaron niveles en orina de 8-isoprostano-f2α por ELISA. Los resultados de la concentración de 8-iso-PGF2α/creatinuria se analizaron mediante el paquete estadístico R. La comparación de factores de riesgo se analizó mediante ANOVA/Kruskal-Wallis. Se generaron curvas ROC para analizar el poder discriminante del biomarcador. El análisis conjunto de resultados de laboratorios y de factores de riesgo se realizó mediante regresiones logísticas multivariantes. Resultados. Se evidenció prevalencia de EAP en 10 pacientes diabéticos. Como factores de riesgo se encontraron: fumar, dislipidemia, mal control metabólico, sobrepeso u obesidad. No se evidenció aumento del 8-isoprostano-f2α urinario en estos sujetos. Conclusiones. La prevalencia de EAP fue menor que en otros estudios, probablemente por el seguimiento médico regular. En este estudio, la determinación mediante ELISA del 8-isoprostano-f2α urinario no permitió identificar EAP en fases tempranas; se recomienda estudiar otros marcadores de estrés oxidativo.

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“…A risk factor for atherosclerotic disease that was significantly different between the two HF groups was smoking, being more prevalent in the HFpEF population (26%x16%, p =0.001). This factor is cited as associated with the risk of PAD in several studies and may have contributed to the high rates of diagnosis of PAD in both populations, although mainly in patients with HFpEF (21,22).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of peripheral arterial disease in patients with heart failure with preserved ejection fraction

Cunha

Brugnarotto

Halal

et al. 2019

Clinics

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OBJECTIVES:To describe the prevalence of the reduced ankle-brachial index (ABI) in patients with heart failure (HF) with preserved ejection fraction (HFpEF) attended at a HF clinic in the metropolitan region of Porto Alegre, and to compar the patients to those with reduced ejection fraction (HFrEF).METHODS:A descriptive observational study, included patients referred to the heart failure clinic in HU-Ulbra with HFpEF or HFrEF and diastolic dysfunction, and measurements of ABIs using vascular Doppler equipment were performed in both groups.RESULTS:The sample consisted of 106 patients with HF, 53.9% of the patients had HFpEF, and 19.4% had a diagnosis of peripheral arterial disease (PAD) (ABI less than 0.9). PAD was identified in 24.1% of the patients with HFpEF, while15.8% of patients in the HFrEF group were diagnosed with PAD.CONCLUSION:Our results did not identify a significantly different prevalence of altered and compatible PAD values in patients with HFpEF. However, we showed a prevalence of 19.4%, a high value if we consider similar populations.

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Environmental tobacco smoke and peripheral arterial disease: A review

Cited by 17 publications

References 50 publications

Burden of Peripheral Artery Disease and Its Attributable Risk Factors in 204 Countries and Territories From 1990 to 2019

Burden of Peripheral Artery Disease and Its Attributable Risk Factors in 204 Countries and Territories From 1990 to 2019

Enfermedad arterial periférica y estrés oxidativo en pacientes del programa para la prevención de complicaciones de diabetes mellitus y dislipidemias

Prevalence of peripheral arterial disease in patients with heart failure with preserved ejection fraction

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