Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts

Abstract

Recently, a survey by the Centers for Disease Control and Prevention (CDC) reported that nearly 90% of U.S. adult smokers began smoking at the age of 18. This demonstrates that the exposure to environmental tobacco smoke (ETS) of youngsters today is changing from passive smoking to active smoking (direct inhalation of tobacco). In the current study, an investigation of ETS exposure in young C57BL mice was conducted. After 6 weeks of ETS exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced. Youngsters' desire to look more mature is one of the psychological factors that impacts smoking amongst young people. Our results suggest that though ETS exposure might cause cardiac autophagy amongst youngsters, the loss of the longevity Sirt-1 protein and the increase in IGF2R cardiac hypertrophy signaling could still promote heart diseases that are age-specific.

The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling

“…The mammalian genome encodes 7 sirtuin isoforms (SIRT 1 to SIRT7) that vary in their tissue specificity, subcellular localization, enzymatic activity, and targets [ 22 , 24 – 25 ]. SIRT6 is a chromatin-associated enzyme involved in deacetylating histone 3 at Lys9 (H3K9) and H3K56, thereby regulating gene expression, cellular metabolism, and the inflammatory response [ 22 ].…”

Resveratrol and Neuroinflammation: Total-Scale Analysis of the Scientific Literature

“…Another term that showed significant occurrence was SIRT-1. Many studies attribute the biological properties of resveratrol to its ability to activate this SIRT-1 [68,[82][83][84], an enzyme classified as an NAD+ dependent histone deacetylase, involved in metabolic processes, cellular stress regulation, and longevity [85,86]. In one study, the researchers demonstrated that the activation of SIRT1 by resveratrol (30 mg/kg/day for 8 weeks) reduced Tau protein phosphorylation induced by streptozotocin injection into the brain, confirming its protective role [87].…”