Environmentally relevant concentrations of titanium dioxide nanoparticles pose negligible risk to marine microbes

Dedman, Craig J.; King, Aaron A.; Christie-Oleza, Joseph Alexander; Davies, G. R.

doi:10.1039/d0en00883d

Cited by 46 publications

(23 citation statements)

References 107 publications

(242 reference statements)

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“…Here, Prochlorococcus was clearly visible within aggregates of nCeO 2 which reached sizes in the 10s-of-micron range. The hetero-aggregation between metal oxide nanomaterials and phytoplankton has previously been reported in the literature (Rodea-Palomares et al, 2010;Manzo et al, 2015;Xia et al, 2015;Wang et al, 2016;Morelli et al, 2018;Dedman et al, 2021), and has been observed with nCeO 2 during 96 h exposure (Deng et al, 2017). It is our belief that the process of entrapment and subsequent co-precipitation of cyanobacteria and nCeO 2 from the water column (Figure 6) is a key mechanism behind the temporary declines in Prochlorococcus presented herein (sections "Short-Term (72 h) Exposure of nCeO 2 Toward Prochlorococcus" and "Alterations in Cell Density of Prochlorococcus in Extended Exposure (240 h)").…”

Section: Discussionmentioning

confidence: 69%

Investigating the Impact of Cerium Oxide Nanoparticles Upon the Ecologically Significant Marine Cyanobacterium Prochlorococcus

et al. 2021

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Cerium oxide nanoparticles (nCeO2) are used at an ever-increasing rate, however, their impact within the aquatic environment remains uncertain. Here, we expose the ecologically significant marine cyanobacterium Prochlorococcus sp. MED4 to nCeO2 at a wide range of concentrations (1 μg L–1 to 100 mg L–1) under simulated natural and nutrient rich growth conditions. Flow cytometric analysis of cyanobacterial populations displays the potential of nCeO2 (100 μg L–1) to significantly reduce Prochlorococcus cell density in the short-term (72 h) by up to 68.8% under environmentally relevant conditions. However, following longer exposure (240 h) cyanobacterial populations are observed to recover under simulated natural conditions. In contrast, cell-dense cultures grown under optimal conditions appear more sensitive to exposure during extended incubation, likely as a result of increased rate of encounter between cyanobacteria and nanoparticles at high cell densities. Exposure to supra-environmental nCeO2 concentrations (i.e., 100 mg L–1) resulted in significant declines in cell density up to 95.7 and 82.7% in natural oligotrophic seawater and nutrient enriched media, respectively. Observed cell decline is associated with extensive aggregation behaviour of nCeO2 upon entry into natural seawater, as observed by dynamic light scattering (DLS), and hetero-aggregation with cyanobacteria, confirmed by fluorescent microscopy. Hence, the reduction of planktonic cells is believed to result from physical removal due to co-aggregation and co-sedimentation with nCeO2 rather than by a toxicological and cell death effect. The observed recovery of the cyanobacterial population under simulated natural conditions, and likely reduction in nCeO2 bioavailability as nanoparticles aggregate and undergo sedimentation in saline media, means that the likely environmental risk of nCeO2 in the marine environment appears low.

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Section: Discussionmentioning

confidence: 69%

Investigating the Impact of Cerium Oxide Nanoparticles Upon the Ecologically Significant Marine Cyanobacterium Prochlorococcus

et al. 2021

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“…Numerous advances of nanoscience and nanotechnology have been reported in recent years on the use of metal oxide nanoparticles (MONPs) in enzymatic biosensors 1 and enzyme-linked immunosorbent assay 1 . The massive production of MONPs for industrial manufacturing of consumer products leads to the inadvertent release of MONPs to the natural aquatic environment 2 . This scenario raises great concerns because ZnO, TiO 2 and CeO 2 all exhibit toxicity towards microorganisms even though their bulk materials are generally considered to be non-toxic 3 .…”

Section: Introductionmentioning

confidence: 99%

Selective removal of ZnO nanoparticles from water using 3-aminopropyltriethoxysilane (APTES) and monitoring by meso-tetra(carboxyphenyl)porphyrin (TCPP)

Zhang

Lai

2021

Preprint

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Metal oxide nanoparticles (MONPs) such as TiO2 and ZnO have been engineered for various industrial manufacturing processes with an annual global production exceeding millions of tonnes. Among MONPs, environmental exposure to ZnO nanoparticles may cause a significant toxicity due to bioaccumulation in the human body. Therefore, detection and removal of ZnO nanoparticles in the aqueous environment is highly desired. In this work, 3-aminopropyltriethoxysilane (APTES) was chosen to treat aqueous suspensions containing ZnO and other metal oxide nanoparticles. APTES first formed a thin surface layer on ZnO nanoparticles and continued in branching polymerization to reach out towards other APTES-ZnO nanoparticles. Eventually, a web-like sediment settled down onto the bottom. A high removal efficiency over 99% has attained for ZnO nanoparticles in aqueous suspension. The sedimentation was selective towards ZnO nanoparticles, due to the amino group of ATPES preferentially interacting with ZnO to form a sturdy condensation coagulate. Other MONPs (such as Al2O3, CaO, CeO2, CuO and TiO2) did not form any web-like sediment with APTES but could co-precipitate with the ZnO nanoparticles. Meso-tetra(carboxyphenyl)porphyrin (TCPP) could be added as an indicator to co-precipitate with the sediment, with its color changing from red purple to bright green during the formation of APTES-TCPP-ZnO sediment.

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“…In terms of being able to inject a large number of TiO 2 NMs into vessels that are endothelial cells (ECs) lined by one epithelial scalp and anticontainous membrane between vessel wall and blood, many biological properties of TiO 2 NMs, including magnetic detection and hyperthermia, require a great deal (Dedman et al., 2021 ; Escudero et al., 2021 ; Liang et al., 2021 ). The ECs is a modulative agent for blood flow and blood vessel sound, which contributes to inflammatory and immune response, coagulation, growth controls, extracellular matrix's formation, and ECs damage, activation, or impairment are characteristic of specific disease conditions, such as atherosclerosis, lack of semi-permeableness and thrombosis (Zhang et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Synergic fabrication of succimer coated titanium dioxide nanomaterials delivery for in vitro proliferation and in vivo examination on human aortic endothelial cells

Song

et al. 2021

Drug Delivery

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The probable nanotoxicity to human health and the environment is a significant challenge for the sustainable application of nanomaterials in medicine. The cytototoxical effect of succimer (meso-2,3-dimercaptosuccinic acid-DMSA) coated titanium dioxide (DMSA-TiO 2 ) with cultured human aortic endothelial cells (HAoECs) was assessed in this investigation. Our findings have shown that DMSA-TiO 2 can be accumulated in HAoECs and dispersed in a cytoplasm on the culture medium. DMSA-cytotoxicity TiO 2 effects were dose-responsive, and the concentrations were of little toxicity, and MTT stain testing showed that they had only 0.02 mg ml −1 . Meanwhile, the lactate dehydrogenase biomarker was not considerably more remarkable than the biomarker from untreated (control) cells (free DMSA-TiO 2 ). Though, also without any apparent signs of cell damage, the endocrine functions for prostacyclin I-2 and endothelin-1 and the urea transporter functions were modified. In addition, in vitro endothelial tube development has been shown that HAoECs could induce angiogenesis even with small amounts of DMSA-TiO 2 (0.01 and 0.02 mg ml −1 ). Further, we have examined the in vivo toxicity and biochemical parameter by animal model. Furthermore, in vivo assessments designated that the resulting DMSA-TiO 2 presented synergistic activities of angiogenesis activity. Overall, these findings show the cytotoxicity of DMSA-TiO 2 and could induce adverse effects on normal endothelial cells.

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Environmentally relevant concentrations of titanium dioxide nanoparticles pose negligible risk to marine microbes

Abstract: Nano-sized titanium dioxide (nTiO2) represents the highest produced nanomaterial by mass worldwide and, due to its prevalent industrial and commercial use, it inevitably reaches the natural environment. Previous work has...

Cited by 46 publications

References 107 publications

Investigating the Impact of Cerium Oxide Nanoparticles Upon the Ecologically Significant Marine Cyanobacterium Prochlorococcus

Investigating the Impact of Cerium Oxide Nanoparticles Upon the Ecologically Significant Marine Cyanobacterium Prochlorococcus

Selective removal of ZnO nanoparticles from water using 3-aminopropyltriethoxysilane (APTES) and monitoring by meso-tetra(carboxyphenyl)porphyrin (TCPP)

Synergic fabrication of succimer coated titanium dioxide nanomaterials delivery for in vitro proliferation and in vivo examination on human aortic endothelial cells

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