Environmentally responsive injectable materials

Bearat, Hanin H.; Vernon, Brent L.

doi:10.1533/9780857091376.3.263

Cited by 11 publications

(9 citation statements)

References 132 publications

(194 reference statements)

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“…In light of the above, the use of polymeric additives featuring an inverse thermal gelling, like poloxamers, is of particular interest for controlling the properties of injectable biomaterials [19]. To the best of our knowledge there are no publications focusing on the combination of reverse thermoresponsive hydrogels with self-hardening calcium phosphate cements.…”

Section: Introductionmentioning

confidence: 99%

Self-hardening and thermoresponsive alpha tricalcium phosphate/pluronic pastes

et al. 2017

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Calcium phosphate cements are attractive bone substitutes due to their similarity to the bone mineral phase. Although they can be injectable, cohesion and stability of the paste are crucial in terms of performance and safety. A common strategy is the combination with hydrogels. However, this often results in a decrease of viscosity with increasing temperature, which can lead to extravasation and particle leakage from the bone defect. The preferred evolution would be the opposite: a low viscosity would enhance mixing and injection, and an instantaneous increase of viscosity after injection would ensure washout resistance to the blood flow. Here we develop for the first time a calcium phosphate cement exhibiting reverse thermoresponsive properties using a poloxamer featuring inverse thermal gelling.

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Section: Introductionmentioning

confidence: 99%

Self-hardening and thermoresponsive alpha tricalcium phosphate/pluronic pastes

et al. 2017

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“…The ionic strength of a solution or media is comprehended as the measure of the concentration of electrically charged species in a solution [37], which changes with the different fluids present throughout the GIT and can be advantageous for the release of on-cargo matrices commonly employed in oral drug release. Moreover, they can be exploited for controlling the response of polymeric biomaterials (e.g., swelling, dissolution, and degradation) [38][39][40][41][42], which, in turn, is critical for the survival of the probiotics [43][44][45]. Moreover, marked changes in the ionic potential of GIT fluids allow the control disaggregation of foods and ingestible encapsulates by destabilization of polypeptide bonds and polymeric structural rearrangements.…”

Section: Ionic Strength and Redox Potentialmentioning

confidence: 99%

“…Typical ionic strength values vary from 0.051 to 0.151 mol/L in the gastric fluid of the stomach and between 0.070-0.166 mol/L in the intestinal fluid [46]. However, as ionic strength is defined by the reactive species at equilibrium present in each GIT compartment, the state of ionic power is also regulated by the food intake and location within the GIT [41].…”

Section: Ionic Strength and Redox Potentialmentioning

confidence: 99%

“…The redox potency is used to describe a system's overall reducing or oxidizing capacity through the presence of chemically reactive species [41]. Its relevance in biological science stems from its role in shaping the structure and function of microbial communities, as demonstrated by the precise communication in the gut microbiome and epithelial cells in the mucosa layers [47,48].…”

Section: Ionic Strength and Redox Potentialmentioning

confidence: 99%

“…In this regard, it has been observed that a strongly charged hydrogel is likely to swell at low ionic strengths due to the strong interchain electrostatic repulsion but shrinks at high ionic strengths due to electrostatic screening effects [187]. Therefore, once a critical ionic strength level is reached, the hydrogel undergoes a conformational change from a swollen to a compact state, resulting in a regime of impeded diffusion [41,188].…”

Section: Ionic Strength and Redox-responsive Matricesmentioning

confidence: 99%

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Novel Developments on Stimuli-Responsive Probiotic Encapsulates: From Smart Hydrogels to Nanostructured Platforms

et al. 2022

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Biomaterials engineering and biotechnology have advanced significantly towards probiotic encapsulation with encouraging results in assuring sufficient bioactivity. However, some major challenges remain to be addressed, and these include maintaining stability in different compartments of the gastrointestinal tract (GIT), favoring adhesion only at the site of action, and increasing residence times. An alternative to addressing such challenges is to manufacture encapsulates with stimuli-responsive polymers, such that controlled release is achievable by incorporating moieties that respond to chemical and physical stimuli present along the GIT. This review highlights, therefore, such emerging delivery matrices going from a comprehensive description of addressable stimuli in each GIT compartment to novel synthesis and functionalization techniques to currently employed materials used for probiotic’s encapsulation and achieving multi-modal delivery and multi-stimuli responses. Next, we explored the routes for encapsulates design to enhance their performance in terms of degradation kinetics, adsorption, and mucus and gut microbiome interactions. Finally, we present the clinical perspectives of implementing novel probiotics and the challenges to assure scalability and cost-effectiveness, prerequisites for an eventual niche market penetration.

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