Enzymatic Degradation of Pentaerythritol Tetranitrate by Human Blood

Abstract

Percent radioactivity i deati fie d * -\ Medium Time (hr) P E T N PE-Trinitrate PE-Dinitrate PE-Mononitrate + PE Phosphate buffer JY Whole blood J 7 J Y Y7 Y J 9 9 YY 'JY Y 7 Blood plwma 7 7 Y J J 7 J 7 YY Y J 7 J 7 3 RBC suspension Y Y JY 77 9 7 J 7 J7 77 Y 7

Isolation and characterization of metabolites of centpropazine in rat liver, intestine, and red blood cell homogenates

“…The nitrato groups of nitroglycerin 9 and that of pentaerythritol nitrates 10 are reduced to nitrito groups that are subsequently hydrolyzed to free hydroxyls. Also reduced by enzymes in blood is a carbonyl group in daunorubicin.…”