Enzyme and Isoenzyme Studies in Preinvasive Carcinoma of the Cervix

Latner, A. L.; Turner, D.M.; Way, Stanley

doi:10.1016/s0140-6736(66)92251-3

Cited by 42 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors deemed the altered LDHA to LDHB ratio as a possible biochemical indicator of an early process of malignant conversion [67]. These conclusions were supported by the data of other investigators who showed high LDHA to LDHB ratios in uninvolved tissues from resection edges that were related to local recurrence possibly due to deep infiltration [58,59,[68][69][70][71]. It is known that LDH-5 overproduction is related exclusively to cancer cells but not to stromal fibroblasts, which have low LDHA expression [72].…”

Section: Clinical Significance Of Ldh Isoenzymesmentioning

confidence: 57%

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

2015

View full text Add to dashboard Cite

Section: Clinical Significance Of Ldh Isoenzymesmentioning

confidence: 57%

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

2015

View full text Add to dashboard Cite

“…Langvad (16) found the uninvolved mucosa of the colon in patients with carci noma of the colon had an M/H ratio resembling the cancer tissue, and Latneret al (17) reached similar conclusions in relation to preinvasive carcinoma of the uterine cervix. …”

Section: Discussionmentioning

confidence: 83%

LDH Isoenzyme Pattern of Uninvolved Gastric Mucosa of Patients with Gastric Carcinoma and Benign Gastric Disease

et al. 1976

View full text Add to dashboard Cite

The LDH isoenzyme pattern of the uninvolved mucosa of gastric cancer patients differs as regards the LDH isoenzyme pattern from that of similar tissue of patients with benign gastric disease; the former tissue is characterised by a high M/H ratio of the LDH isoenzymes (M and H sub-units). A high M/H ratio characterises antral mucosa when the latter is compared with fundic mucosa. Mucosa showing superficial and atrophic gastritis also has a higher M/H ratio, whereas the presence of intestinal metaplasia does not appear to influence the M/H ratio. These observations are consistent with the concept that the tissue from which the cancer arose may possess a pre-malignant biochemical lesion.

show abstract

“…Latner et al (9) found in the morphological normal tissue which lies around the cervix, cancer an intermedium LDH isoenzyme between the normal and tumoral tissue. Stagg and Why la (15) susepcted that these changes were due to the existence of a mixture of both malignant and benign cells in the same peritumoral tissue sample.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Lactic Dehydrogenase Patterns in Carcinoma of Stomach and in Peritumoral Tissues

Mate¹,

Jm²,

Moreno–Otero³

et al. 1978

Digestion

View full text Add to dashboard Cite

Segments of gastric mucosa from 32 surgical and biopsy specimens containing gastric carcinoma have been studied to determine the total content of lactate dehydrogenase (LDH). The LDH isoenzyme distribution patterns in tumoral tissues have been compared to that of peritumoral tissue and to the gastric mucosa of a healthy control group. LDH isoenzyme activity in the samples from tumoral tissue was significantly increased. The adjacent peritumoral tissue had a slight increment in the polypeptide M as compared to the distant and normal tissue. This suggests that LDH isoenzyme measurement may prove a valuable addition to histologic study, in the recognition of the tumoral distribution in stomach carcinoma.

show abstract

Enzyme and Isoenzyme Studies in Preinvasive Carcinoma of the Cervix

Cited by 42 publications

References 4 publications

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

LDH Isoenzyme Pattern of Uninvolved Gastric Mucosa of Patients with Gastric Carcinoma and Benign Gastric Disease

Abnormal Lactic Dehydrogenase Patterns in Carcinoma of Stomach and in Peritumoral Tissues

Contact Info

Product

Resources

About