Enzyme-Assisted Photodynamic Therapy Based on Nanomaterials

Du, Baoji; Tung, Ching–Hsuan

doi:10.1021/acsbiomaterials.9b00968

Cited by 29 publications

(17 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the second form, PDT itself causes rapid inhibition of the tumor vasculature, leading to rapid depletion of the local oxygen supply 87 . In any case, solid tumors with a high percentage of hypoxic cells have strong resistance to PDT, making it very difficult to continuously perform PDT 88 . The key molecular mechanism of hypoxia begins with the activation of hypoxia-inducible factor-1 (HIF-1), which is a major effector and transcriptional regulator.…”

Section: Introductionmentioning

confidence: 99%

Tailoring photosensitive ROS for advanced photodynamic therapy

et al. 2021

View full text Add to dashboard Cite

Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective modality for tumor treatment. However, the complexity of tumor microenvironments poses challenges to the implementation of traditional PDT. Here, we review recent advances in PDT to resolve the current problems. Major breakthroughs in PDTs are enabling significant progress in molecular medicine and are interconnected with innovative strategies based on smart bio/nanomaterials or therapeutic insights. We focus on newly developed PDT strategies designed by tailoring photosensitive reactive oxygen species generation, which include the use of proteinaceous photosensitizers, self-illumination, or oxygen-independent approaches. While these updated PDT platforms are expected to enable major advances in cancer treatment, addressing future challenges related to biosafety and target specificity is discussed throughout as a necessary goal to expand the usefulness of PDT.

show abstract

Section: Introductionmentioning

confidence: 99%

Tailoring photosensitive ROS for advanced photodynamic therapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Additionally, numerous recent studies have utilized catalase to increase the efficiency of photodynamic therapy by resolving tumor hypoxia through oxygen production, but they are not of interest in this article. [ 102 ] Simple loading of catalase into polymeric NPs is a straightforward approach for the protection of the enzyme. An early study has demonstrated that encapsulating catalase into PEG–PLGA NPs can retain enzymatic activity under protease conditions.…”

Section: Polymer‐based Delivery Of Antioxidantsmentioning

confidence: 99%

Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders

Yeo

Lee

et al. 2021

Advanced Therapeutics

View full text Add to dashboard Cite

Reactive oxygen and nitrogen species (RONS) play a key role in physiological conditions as signaling molecules for regulating homeostasis in the human body. However, abnormally increased RONS levels can damage DNA, protein, and tissue, or even impair cellular signaling. Consequently, when this state is present for a long time, it can lead to severe inflammatory disorders, such as lupus, diabetes, rheumatoid arthritis, Crohn's disease, and neurodegenerative disorders. Although antioxidant therapies have been developed for a long time to treat acute or chronic inflammatory diseases, small molecule‐based antioxidants showed relatively low therapeutic effects due to rapid clearance and low stability in the bloodstream. As one of the solutions to overcome such limitations, incorporating polymers would provide enhanced blood stability, bioavailability, and even enhanced therapeutic effects. Herein, diverse polymeric antioxidant materials are introduced that are categorized into simple loading strategies and polymers with inherent antioxidative activity. Further, preclinical and clinical studies of polymeric antioxidant materials for anti‐inflammatory therapy are discussed and a better direction is provided for these to be pursued and improved in anti‐inflammatory therapy.

show abstract

“…Upregulation of endogenous enzymes on the surface of tumor environment for O 2 generation heavily trusts on catalase loaded nanocarriers for which understanding the strategic role of PDT in the presence of a photosensitizer (PS), oxygen, and light is essential especially for non‐invasive cancers. [ 159 ] In this context, the release of the enzymes and its control in the TME including self‐acceleration mechanism is required to understand. A greater control over systemic toxicity in a deoxygenation‐activated chemotherapy can be achieved for which nanoclustered cascaded enzymes paves an avenue.…”

Section: Perspectivesmentioning

confidence: 99%

Biocompatible nanoreactors of catalase and nanozymes for anticancer therapeutics

Munjal

Dutta

2021

Nano Select

View full text Add to dashboard Cite

Significant progress has laid the groundwork in understanding the fundamental role of catalase enzyme and catalase-like nanozymes, notably with the emergence of nano-bioreactors which are promoting nanomaterials-based antitumor therapeutic strategies. The radiotherapy techniques such as photodynamic, photothermal, photoacoustic and along with chemotherapy are extensively used for interrupting microenvironment by exerting to locally applied ionizingradiations. Nevertheless, tumor therapy not only deficient in therapeutic efficiency for various solid tumors but also alerts significant side effects. The convergence of nano-bioreactor driven catalase delivery at the lysosome of tumor cells with photodynamic therapy (PDT) tool along with the engineered catalase-like nanozymes enable outstanding efficacy of radiotherapy for in vivo target specific cell population. Herein, the state of the art of catalase delivering nano-bioreactors that activate the catalase delivery in tumor microenvironment (TME) are reviewed. This was linked with the functional mimic catalase-like engineered nanozymes for improving the challenges in the TME for a widerange of cell lines in vivo. Such nanoarchitecture-based strategies of catalase and synthetic nanozymes include lysosomal upregulation of H 2 O 2 in TME, image-based probing, and mechanism of catalase action for reactive oxygen species generation which are likely to amplify efficiency of cancer therapy.

show abstract

Enzyme-Assisted Photodynamic Therapy Based on Nanomaterials

Cited by 29 publications

References 102 publications

Tailoring photosensitive ROS for advanced photodynamic therapy

Tailoring photosensitive ROS for advanced photodynamic therapy

Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders

Biocompatible nanoreactors of catalase and nanozymes for anticancer therapeutics

Contact Info

Product

Resources

About