“…Lysozyme is a good model because both large (∼μm) and small (∼nm) size substrates can be catalyzed by this enzyme ( Vocadlo et al., 2001 , Kao et al., 2014 ). Meanwhile, MOFs/COFs are advanced porous platforms for enzyme encapsulation ( Howarth et al., 2016 , Majewski et al., 2017 , Drout et al., 2019 , Wang et al., 2020 , Gkaniatsou et al., 2017 , Lyu et al., 2014 , Lian et al., 2017 , Li et al., 2020 , Farmakes et al., 2020 , Neupane et al., 2019 ). Note that, a unique feature of SDSL-EPR is that it is immune of the background matrices (under low water volume; see below) ( Pan et al., 2021a ).…”