Enzyme mimic nanomaterials as nanozymes with catalytic attributes

Bilal, Muhammad; Khaliq, Nida; Ashraf, Mubeen; Hussain, N.; Baqar, Zulqarnain; Zdarta, Jakub; Jesionowski, Teofil; Iqbal, Hafiz M.N.

doi:10.1016/j.colsurfb.2022.112950

Cited by 60 publications

(13 citation statements)

References 79 publications

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“…It has also been demonstrated that platinum and palladium nanozymes have more efficient catalase-mimicking activity than gold and silver nanoparticles, which explains why platinum is widely used in biosensing and PDT (photodynamic therapy). 63,64 On the other hand, studies have also unveiled that FeNPs act as catalase mimetics at high pH and as peroxidase mimetics at lower pH. 65 This evidence was supported by the fact that FeNPs entrapped in lysosomal vesicles at low pH cause cell death by exhibiting peroxidaselike activity, while they cause no damage to the cells in the cytoplasmic environment, where they exhibit catalase-like activity at neutral pH.…”

Section: ■ Nanozymes: Structure and Functionsmentioning

confidence: 99%

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Singh,

Rai,

Tiwari

et al. 2023

ACS Appl. Bio Mater.

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Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming their drawbacks related to stability, cost, and storage. Nanozymes have the potential to manipulate active sites of natural enzymes, which is why they are considered promising candidates to function as enzyme mimetics. Several microscopy- and spectroscopy-based techniques have been used for the characterization of nanozymes. To date, a wide range of nanozymes, including catalase, oxidase, peroxidase, and superoxide dismutase, have been designed to effectively mimic natural enzymes. The activity of nanozymes can be controlled by regulating the structural and morphological aspects of the nanozymes. Nanozymes have multifaceted benefits, which is why they are exploited on a large scale for their application in the biomedical sector. The versatility of nanozymes aids in monitoring and treating cancer, other neurodegenerative diseases, and metabolic disorders. Due to the compelling advantages of nanozymes, significant research advancements have been made in this area. Although a wide range of nanozymes act as potent mimetics of natural enzymes, their activity and specificities are suboptimal, and there is still room for their diversification for analytical purposes. Designing diverse nanozyme systems that are sensitive to one or more substrates through specialized techniques has been the subject of an in-depth study. Hence, we believe that stimuli-responsive nanozymes may open avenues for diagnosis and treatment by fusing the catalytic activity and intrinsic nanomaterial properties of nanozyme systems.

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Section: ■ Nanozymes: Structure and Functionsmentioning

confidence: 99%

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Singh,

Rai,

Tiwari

et al. 2023

ACS Appl. Bio Mater.

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“…However, traditional nanozymes still face many challenges in their practical applications. First, it is difficult to precisely identify enzyme-like active sites, revealing structure–activity relationships due to the factors such as morphology, elemental composition, surface configuration with different crystal structures, and so on. − Second, it is still hampered by the difficulty of accurately simulating the complex coordination structure and catalytic microenvironment of the natural enzyme catalytic center, which pose great challenges to improving their catalytic activity and specificity. − These problems have seriously hampered the development of nanozymes. To further overcome the above limitations of nanozymes, recently many studies began to explore single-atom nanozymes (SAzymes).…”

Section: Introductionmentioning

confidence: 99%

Perspectives for the Role of Single-Atom Nanozymes in Assisting Food Safety Inspection and Food Nutrition Evaluation

Wu,

Xia,

et al. 2024

Anal. Chem.

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Single-atom nanozymes (SAzymes) have been greatly developed for rapid detection, owing to their rich active sites and excellent catalytic activity. Although several excellent reviews concentrating on SAzymes have been reported, they mainly focused on advanced synthesis, sensing mechanisms, and biomedical applications. To date, few reviews elaborate on the promising applications of SAzymes in food safety inspection and food nutrition evaluation. In this paper, we systematically reviewed the enzyme-like activity of SAzymes and the catalytic mechanism, in addition to recent research advances of SAzymes in the domain of food safety inspection and food nutrition evaluation in the past few years. Furthermore, current challenges hampering practical applications of SAzymes in food assay are summarized and analyzed, and possible research areas focusing on SAzyme-based sensors in rapid food testing are also proposed.

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“…Nanozymes, nanoparticle-based articial enzymes, have been actively investigated owing to their advantages over natural enzymes; their advantages include controllable and facile synthesis, tunability in catalytic activities, cost-effectiveness, and high stability against stringent conditions. [1][2][3][4][5][6] Owing to these advantages, they are widely applied in various elds, including H 2 generation, CO 2 reduction, wastewater treatment, organic reactions, biosensors, cancer therapy, energy transfer, and pollutant removal. 4,[7][8][9][10][11][12][13] Representative nanozymes include metal oxide-or sulde-based materials (e.g., Fe 3 O 4 , CeO 2 , Co 9 S 8 , CuO, MnO 2 ); metal-based materials (e.g., Au, Ag, Pt, and Ir); and carbon-based materials (e.g., carbon dots (CDs), g-C 3 N 4 , graphene, CNT).…”

Section: Introductionmentioning

confidence: 99%

“…4,[7][8][9][10][11][12][13] Representative nanozymes include metal oxide-or sulde-based materials (e.g., Fe 3 O 4 , CeO 2 , Co 9 S 8 , CuO, MnO 2 ); metal-based materials (e.g., Au, Ag, Pt, and Ir); and carbon-based materials (e.g., carbon dots (CDs), g-C 3 N 4 , graphene, CNT). 1,4,14 CDs are emerging as enzyme-like catalytic agents, such as peroxidase, oxidase, and catalase, through proton-coupled electron transfer. 15,16 They contain graphenelike crystalline sp 2 domains and various defect sites at their edges.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing catalytic efficiency of carbon dots by modulating their Mn doping and chemical structure with metal salts

et al. 2023

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Enzyme mimic nanomaterials as nanozymes with catalytic attributes

Cited by 60 publications

References 79 publications

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Perspectives for the Role of Single-Atom Nanozymes in Assisting Food Safety Inspection and Food Nutrition Evaluation

Enhancing catalytic efficiency of carbon dots by modulating their Mn doping and chemical structure with metal salts

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