Enzyme Molecules as Nanomotors

Sengupta, S.; Dey, Krishna Kanti; Muddana, Hari S.; Tabouillot, Tristan; Ibele, Michael E.; Butler, Peter J.; Sen, Ayusman

doi:10.1021/ja3091615

Cited by 293 publications

(435 citation statements)

References 47 publications

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“…Sen and coworkers (39,40) have shown that catalytically active enzymes have larger diffusion coefficients than their inactive counterparts in the absence of substrate. Recently, chemotaxislike drift of enzymes in the presence of substrate gradients has been observed and used for sorting of the enzymes (41).…”

Section: Discussionmentioning

confidence: 99%

Hydrodynamic collective effects of active protein machines in solution and lipid bilayers

Mikhailov

Kapral

2015

Proc. Natl. Acad. Sci. U.S.A.

100

113

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The cytoplasm and biomembranes in biological cells contain large numbers of proteins that cyclically change their shapes. They are molecular machines that can function as molecular motors or carry out various other tasks in the cell. Many enzymes also undergo conformational changes within their turnover cycles. We analyze the advection effects that nonthermal fluctuating hydrodynamic flows induced by active proteins have on other passive molecules in solution or membranes. We show that the diffusion constants of passive particles are enhanced substantially. Furthermore, when gradients of active proteins are present, a chemotaxis-like drift of passive particles takes place. In lipid bilayers, the effects are strongly nonlocal, so that active inclusions in the entire membrane contribute to local diffusion enhancement and the drift. All active proteins in a biological cell or in a membrane contribute to such effects and all passive particles, and the proteins themselves, will be subject to them

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Section: Discussionmentioning

confidence: 99%

Hydrodynamic collective effects of active protein machines in solution and lipid bilayers

Mikhailov

Kapral

2015

Proc. Natl. Acad. Sci. U.S.A.

100

113

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“…While the results of Fukushima and coworkers [91] may seem surprising, recent work indicating an ability of low-entropy sunlight to impart long-range order in bulk as well as surface water [92] provides a plausible route by which water CD's may provide energy catalyzing chemical reactions not only at enzymes but indeed near many hydrophobic or hydrophilic surfaces [93,94], as well as for actual diffusion of enzymes through bulk aqueous solution toward areas of high local substrate concentration [95][96][97].…”

Section: Interaction With Electric and Magnetic Fieldsmentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

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This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

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“…Bacteria and other single-or multi-cellular organisms propel themselves up or down the concentration gradient of a particular substance in their search for nutrients or to avoid antagonists. Inspired by chemotaxis in biology, researchers synthesized artificial microswimmers [2,3] that can move in response to a chemical stimulus [4,5]. They showed that Janus particles (JP), in the form of two-faced Au-Pt colloidal rods that catalyze hydrogen peroxide redox, are attracted by a hydrogen peroxide source.…”

Section: Introductionmentioning

confidence: 99%

Pseudochemotactic drifts of artificial microswimmers

Ghosh

Marchesoni

et al. 2015

Phys. Rev. E

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We numerically investigate the motion of active artificial microswimmers diffusing in a fuel concentration gradient. We observe that, in the steady state, their probability density accumulates in the low-concentration regions, whereas a tagged swimmer drifts with velocity depending in modulus and orientation on how the concentration gradient affects the self-propulsion mechanism. Under most experimentally accessible conditions, the particle drifts toward the high-concentration regions (pseudo-chemotactic drift). A correct interpretation of experimental data must account for such an "anti-Fickian" behavior.

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Enzyme Molecules as Nanomotors

Cited by 293 publications

References 47 publications

Hydrodynamic collective effects of active protein machines in solution and lipid bilayers

Hydrodynamic collective effects of active protein machines in solution and lipid bilayers

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Pseudochemotactic drifts of artificial microswimmers

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