Enzyme Technology in Biofuel Production

Vipparla, Chetana; Sarkar, Silpi; Manasa, B.; Pattela, Thireesha; Nagari, Dikshit Chandra; Aradhyula, Thirumala Vasu; Paul, Tania

doi:10.1007/978-981-16-8094-6_14

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…PMLA exhibits distinctive attributes, including water solubility, biodegradability, biocompatibility, non-toxicity, non-immunogenicity, and a renewable raw material source. The use of process optimization also plays a critical aspect in this regard [13,14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Creating innovative pH-responsive PMLA nanoparticles for the targeted transport of Amoxicillin to combat pathogenic microorganisms

2024

IRJMETS

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Thiolated chitosan/PMLA nanoparticles, featuring cysteine conjugation, were synthesized to serve as a sophisticated nano-level drug transportation system aimed at eradicating Helicobacter pylori. This bacterium notably expresses a membrane protein for importing urea in the cytoplasm and aids in supplying ammonia for its protection within the acidic stomach environment. In this research endeavor, a novel cysteine-amalgamated derivative of chitosan, termed Cys-CS, was designed and synthesized. This derivative was specifically tailored to possess mucoadhesive and anticoagulant properties, thereby facilitating its incorporation into multifunctional nanoparticles. The optimized technique allowed for the preparation of nanoparticles with the primary goal of encapsulating amoxicillin. The experimental findings revealed that antibiotic-loaded nanoparticles exhibited favorable pH-susceptible characteristics, effectively delaying the release of amoxicillin within the gastric acid milieu. This property enabled the precise delivery and targeting of the drug to Helicobacter pylori within its survival niche. Comparatively, when contrasted with unmodified antibiotic-nanoparticles conjugate, the antibiotic-loaded nanoparticles exhibited remarkable inhibition of Helicobacter pylori growth. The findings emphasize the significant promise of nanoparticles loaded with antibiotics for the efficient management of H. pylori infections.

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Section: Introductionmentioning

confidence: 99%

Creating innovative pH-responsive PMLA nanoparticles for the targeted transport of Amoxicillin to combat pathogenic microorganisms

2024

IRJMETS

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“…The world faces numerous critical challenges (Roy and Ray 2019;Roy and Ray 2020), with environmental issues, water scarcity, and human health concerns standing out (Roy, Debnath, and Chakraborty 2022;. Health-related issues are especially significant Song et al 2022;Su et al 2022), often linked to microorganisms and their products, such as enzymes (Ghoshal et al 2022;Vipparla et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Antimicrobial Potential of Silver Nanoparticles against Two Prominent Mycobacterium Tuberculosis Strains

Panda,

Manna,

Choudhary

2023

Int. J. Res. Publ. Rev.

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Tuberculosis (TB) stands as a prominent global health concern. This study aims to assess the impact of silver nanoparticles (AgNP) on Mycobacterium tuberculosis, the causative agent of TB. The efficacy of AgNP was determined using the minimum inhibitory concentration (MIC) through a microplate Alamar blue assay.AgNP synthesis involves chemical methods. The size and shape of AgNP were verified through ultraviolet-visible (UV-Vis) absorption spectroscopy, X-ray diffraction (XRD) spectroscopy, and transmission electron microscopy (TEM). Two strains were examined: Mycobacterium tuberculosis H37Rv and Mycobacterium bovis. Furthermore, a multidrug-resistant Mycobacterium tuberculosis strain was included, along with clinically obtained isolates from Mycobacterium tuberculosis H37Rv and Mycobacterium bovis. The synthesized nanoparticles appeared tetrahedral in shape with an average size of 45±3 nanometers (nm). Results showed that the synthesized AgNPs effectively inhibited the growth of all strains, including the multidrug-resistant strain. The MIC for the multidrug-resistant strain ranged from 2-12 µg/ml, while for Mycobacterium tuberculosis H37Rv and Mycobacterium bovis, it ranged from 2-14 µg/ml and 3-30 µg/ml, respectively. This study presents a novel approach to combat tuberculosis, a global threat to humanity, highlighting its innovative potential.

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Determination of the antagonistic efficacy of silver nanoparticles against two major strains of Mycobacterium tuberculosis

Sadhu

Karmakar

Chatterjee³

et al. 2022

IJERR

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Tuberculosis (TB) is considered one of the most prominent diseases across the globe. This present study aims to inspect the impact of silver nanoparticles (AgNP) against Mycobacterium tuberculosis, which is the causative vector of TB. The efficacy of the AgNP was conducted based on the minimum inhibitory concentration (MIC) of the AgNPs through microplate Alamar blue assay. The preparation of the AgNPs involved chemical synthesis. The state and the size of the AgNPs were determined and confirmed by using ultraviolet-visible (UV-Vis) absorption spectroscopy, X-ray diffraction (XRD) spectroscopy, and Transmission electron microscopy (TEM). This study evaluated two strains: Mycobacterium tuberculosis H37Rv and Mycobacterium bovis. In addition, another multiple drug-resistant Mycobacterium tuberculosis strain was also considered in this study, along with the clinically obtained isolates from Mycobacterium tuberculosis H37Rv and Mycobacterium tuberculosis bovis. The synthesized nanoparticles were found to be tetrahedral in shape with an average particle size of 45±3 nanometre (nm). The obtained results indicated that the proliferation of all the strains (two reference strains and one MDR strain) was resisted by the action of the synthesized AgNPs. The MIC of the MDR strain was noted within the range of 2-12 µg/ml, whereas the MIC for the Mycobacterium tuberculosis H37Rv and Mycobacterium bovis was noted in the range of 2-14 and 3-30 µg/ml, respectively. Accordingly, this study proposed a novel approach to combat tuberculosis, which is considered a global threat to humankind, indicating the present study's novelty.

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Enzyme Technology in Biofuel Production

Cited by 3 publications

References 51 publications

Creating innovative pH-responsive PMLA nanoparticles for the targeted transport of Amoxicillin to combat pathogenic microorganisms

Creating innovative pH-responsive PMLA nanoparticles for the targeted transport of Amoxicillin to combat pathogenic microorganisms

Evaluating the Antimicrobial Potential of Silver Nanoparticles against Two Prominent Mycobacterium Tuberculosis Strains

Determination of the antagonistic efficacy of silver nanoparticles against two major strains of Mycobacterium tuberculosis

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