Enzymetically Regulating the Self‐Healing of Protein Hydrogels with High Healing Efficiency

Gao, Yuzhou; Luo, Quan; Qiao, Shanpeng; Wang, Liang; Dong, Zeyuan; Xu, Jing

doi:10.1002/anie.201404531

Cited by 62 publications

(59 citation statements)

References 27 publications

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“…Injectable chemically cross‐linked hydrogels are generated by introducing covalent linkages between polymer chains through Schiff's base reactions, photo‐irradiation, enzyme, Michael‐type addition reaction, disulfide formation, and Diels–Alder reaction . Once intermolecular cross‐linking has occurred with adequate cross‐linking density due to the generation of new covalent bonds, three‐dimensional (3D) network structures may be formed.…”

Section: Injectable Hydrogels For Drug Co‐deliverymentioning

confidence: 99%

Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics‐Based Combination Antitumor Therapy

Chen

2018

Macromolecular Bioscience

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Different strategies of chemotherapeutics‐based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side effects limit their efficacy and application in the clinic. Local drug co‐delivery systems based on injectable hydrogels may have considerable advantages, such as a facile drug‐delivery procedure, targeted delivery of antitumor agents to tumor sites in a sustained manner, and markedly reduced systemic toxicities. Thus, in recent years, these systems have received increasing attention and consequently various injectable hydrogels have been tested as platforms for local chemotherapeutics‐based combination antitumor therapy. In this review, the focus is on recent advances in injectable hydrogel‐based drug co‐delivery systems for local combination antitumor therapy, including multiple chemotherapeutics combination therapy, chemo‐immunotherapy, chemo‐radiotherapy, and hyperthermia‐chemotherapy. Moreover, the rationale and preparation of local co‐delivery systems are summarized and discussed.

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Section: Injectable Hydrogels For Drug Co‐deliverymentioning

confidence: 99%

Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics‐Based Combination Antitumor Therapy

Chen

2018

Macromolecular Bioscience

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“…A direct and simple way of incorporating proteins into cross‐linked structures is the use of protein molecules as cross‐linkers. Amino and carboxylic acid groups on proteins were used directly in the cross‐linking reactions, or modified with the active functional groups for further cross‐linking reactions . For example, Yamauchi and co‐workers synthesized hydrogels based on a reaction between the NHS‐modified alginic acid (AL) and the HSA macro‐cross‐linker .…”

Section: Synthesis Of Protein–polymer Nanogels/hydrogelsmentioning

confidence: 99%

Fabrication of Polymer–Protein Hybrids

Zhang

Zhao

2018

Macromol. Rapid Commun.

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Rapid developments in organic chemistry and polymer chemistry promote the synthesis of polymer-protein hybrids with different structures and biofunctionalities. In this feature article, recent progress achieved in the synthesis of polymer-protein conjugates, protein-nanoparticle core-shell structures, and polymer-protein nanogels/hydrogels is briefly reviewed. The polymer-protein conjugates can be synthesized by the "grafting-to" or the "grafting-from" approach. In this article, different coupling reactions and polymerization methods used in the synthesis of bioconjugates are reviewed. Protein molecules can be immobilized on the surfaces of nanoparticles by covalent or noncovalent linkages. The specific interactions and chemical reactions employed in the synthesis of core-shell structures are discussed. Finally, a general introduction to the synthesis of environmentally responsive polymer-protein nanogels/hydrogels by chemical cross-linking reactions or molecular recognition is provided.

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“…Furthermore, some unique properties of self-healing materials are quite intriguing to in vivo applications. One instance is a bovine serum albumin (BSA) hydrogel regulated by glucose oxidase (GO X ) and catalase (CAT), in which recovery is stimulated by the presence of glucose and 100% healing efficiency could be obtained within 5 h at room temperature [25]. Due to the broad applications of selfhealing materials, this section mainly focuses on summarizing and discussing various applications of self-healing materials in the biomedical field.…”

Section: Self-healing Materials For Potential Biomedical Applicationsmentioning

confidence: 99%

Functional self-healing materials and their potential applications in biomedical engineering

Chen

Huang

et al. 2017

Adv Compos Hybrid Mater

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With the development of smart materials, stimulus-responsive self-repairing materials attract more and more research attention. Although self-healing materials including concretes, rubbers, and hydrogels have been extensively investigated in the past decades, novel functionalities or properties such as shape memory, sol-gel transition, adhesion, anti-biofouling, and electronic/magnetic property have been introduced to self-repairing systems in recent years in order to broaden the scope of their applications in energy, drug delivery, tissue adhesion, cell culture, etc. In this paper, we first present an overview of the general strategies to prepare self-healing materials and the characterization methods to assess their healing performance. Then, we mainly focus on reviewing recent progress in novel self-healing materials possessing unique functionalities and their potential applications in biomedical engineering. Finally, the challenges and scope for future development are also discussed.

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Enzymetically Regulating the Self‐Healing of Protein Hydrogels with High Healing Efficiency

Cited by 62 publications

References 27 publications

Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics‐Based Combination Antitumor Therapy

Injectable Hydrogels as Unique Platforms for Local Chemotherapeutics‐Based Combination Antitumor Therapy

Fabrication of Polymer–Protein Hybrids

Functional self-healing materials and their potential applications in biomedical engineering

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