Enzymic polymerization of porphobilinogen into uroporphyrinogens

Der „umgedrehte Ring”︁ in Uroporphyrinogen III (Uro'gen III), der Stammverbindung aller natürlichen Porphyrine etc., könnte auf zwei Wegen zustandekommen: 1. durch Isomerisierung eines Kopf‐Schwanz‐verknüpften Bilans wie (1) beim Ringschluß oder 2. durch Bildung einer Vorstufe mit „umgedrehtem”︁ Ring. Nach neuen enzymatischen Studien wird der erste Weg beschritten. magnified image

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Enzymatische Bildung von Uroporphyrinogen I und III aus einem substituierten Bilan

Kammerer

Wörner

Müller

1979

Angewandte Chemie

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Enzymatic Formation of Uroporphyrinogen I and III from a Substituted Bilane

Kammerer

Wörner

Müller

1979

Angew. Chem. Int. Ed. Engl.

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Porphobilinogen deaminase and uroporphyrinogen III synthase: Structure, molecular biology, and mechanism

Shoolingin‐Jordan

1995

J Bioenerg Biomembr

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Porphobilinogen deaminase (hydroxymethylbilane synthase) and uroporphyrinogen III synthase (uroporphyrinogen III cosynthase) catalyze the transformation of four molecules of porphobilinogen, via the 1-hydroxymethylbilane, preuroporphyrinogen, into uroporphyrinogen III. A combination of studies involving protein chemistry, molecular biology, site-directed mutagenesis, and the use of chemically synthesized substrate analogs and inhibitors is helping to unravel the complex mechanisms by which the two enzymes function. The determination of the X-ray structure of E. coli porphobilinogen deaminase at 1.76 A resolution has provided the springboard for the design of further experiments to elucidate the precise mechanism for the assembly of both the dipyrromethane cofactor and the tetrapyrrole chain. The human deaminase structure has been modeled from the E. coli structure and has led to a molecular explanation for the disease acute intermittent porphyria. Molecular modeling has also been employed to stimulate the spiro-mechanism of uroporphyrinogen III synthase.

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Enzymic polymerization of porphobilinogen into uroporphyrinogens

Cited by 24 publications

References 69 publications

Enzymatische Bildung von Uroporphyrinogen I und III aus einem substituierten Bilan

Enzymatische Bildung von Uroporphyrinogen I und III aus einem substituierten Bilan

Enzymatic Formation of Uroporphyrinogen I and III from a Substituted Bilane

Porphobilinogen deaminase and uroporphyrinogen III synthase: Structure, molecular biology, and mechanism

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