Enzymic Synthesis of Polysaccharides: a Biological type of Polymerization

Hehre, Edward J.

doi:10.1002/9780470122563.ch6

Cited by 16 publications

(4 citation statements)

References 142 publications

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“…Oral streptococcal GTFs (EC: 2.4.1.5) [41] are encoded by gtf genes, belong to the glycosyl hydrolase family 70 and basically catalyze the transfer of D-glucopyranosyl units from sucrose to acceptor molecules [42]. Biochemically, GTFs are classified into mainly 2 types according to their products, water-soluble glucan (WSG) and water-insoluble glucan (WIG), main components of oral biofilm.…”

Section: Catechins As Inhibitors Of Glucosyltransferasementioning

confidence: 99%

Recent Progress of Basic Studies of Natural Products and Their Dental Application

et al. 2018

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The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous cell carcinoma cell lines, with much lower toxicity against human oral keratinocytes, as compared with various anticancer drugs. QSAR analysis suggests the possible correlation between their tumor-specificity and three-dimensional molecular shape. Condensed tannins in the tea extracts inactivated the glucosyltransferase enzymes, involved in the biofilm formation. Lignin-carbohydrate complexes (prepared by alkaline extraction and acid-precipitation) and crude alkaline extract of the leaves of Sasa species (SE, available as an over-the-counter drug) showed much higher anti-HIV activity, than tannins, flavonoids and Japanese traditional medicine (Kampo). Long-term treatment with SE and several Kampo medicines showed an anti-inflammatory and anti-oxidant effects in small size of clinical trials. Although the anti-periodontitis activity of synthetic angiotensin II blockers has been suggested in many papers, natural angiotensin II blockers has not yet been tested for their possible anti-periodontitis activity. There should be still many unknown substances that are useful for treating the oral diseases in the natural kingdom.

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Section: Catechins As Inhibitors Of Glucosyltransferasementioning

confidence: 99%

Recent Progress of Basic Studies of Natural Products and Their Dental Application

et al. 2018

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“…The term transglycosylation was first introduced in 1951 by Hehre [ 129 ]. Although amylases are the most widely used enzymes for preparing maltooligosaccharides, transglycosylation reactions might also be used for this purpose.…”

Section: Overview Of Different Ways Of Producing Maltooligosaccharidesmentioning

confidence: 99%

Maltooligosaccharides: Properties, Production and Applications

et al. 2023

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Maltooligosaccharides (MOS) are homooligosaccharides that consist of 3–10 glucose molecules linked by α-1,4 glycosidic bonds. As they have physiological functions, they are commonly used as ingredients in nutritional products and functional foods. Many researchers have investigated the potential applications of MOS and their derivatives in the pharmaceutical industry. In this review, we summarized the properties and methods of fabricating MOS and their derivatives, including sulfated and non-sulfated alkylMOS. For preparing MOS, different enzymatic strategies have been proposed by various researchers, using α-amylases, maltooligosaccharide-forming amylases, or glycosyltransferases as effective biocatalysts. Many researchers have focused on using immobilized biocatalysts and downstream processes for MOS production. This review also provides an overview of the current challenges and future trends of MOS production.

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“…Este es sintetizado por la enzima dextransacarasa, la cual es una glucosiltransferasa que cataliza la transferencia de los residuos de glucosilo de la sacarosa al polímero de dextrano y libera fructuosa. (Hehre, 1951).…”

Section: Q22o Generación De Materiales De Alto Valor Agregado a Paunclassified

Memorias del VII Congreso de la Red Latinoamericana de Ciencias Ambientales

Guzmán¹

2013

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Enzymic Synthesis of Polysaccharides: a Biological type of Polymerization

Cited by 16 publications

References 142 publications

Recent Progress of Basic Studies of Natural Products and Their Dental Application

Recent Progress of Basic Studies of Natural Products and Their Dental Application

Maltooligosaccharides: Properties, Production and Applications

Memorias del VII Congreso de la Red Latinoamericana de Ciencias Ambientales

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