Eosinopenia Dan Procalcitonin Dalam Sepsis

Abstract

Sepsis is one of the common causes of morbidity and mortality in the ICU. Clinicians need to know and realize of good diagnosticmarkers to identify sepsis as early as possible. The role of eosinopenia as a marker of sepsis has recently been evaluated.The aim of thisstudy was to test the value of eosinopenia as a diagnostic marker of sepsis in comparison to Procalcitonin. A cross sectional study wasperformed in 61 adult patients with SIRS, and blood of all patients were cultured. Further examinations were done for comparing theeosinophil count with the Procalcitonin levels if the blood culture was positive or when there were clinical signs which supported for sepsis.In this study there were fourty two patients enrolled. Procalcitonin level yielded a sensitivity of 90.0%, specificity of 83.3%, a positivepredictive value (PPV) of 93.1% and a negative predictive value (NPV) of 76.9% at cut-off value of 2.75 ng/mL. The eosinophil (cut off ≤50 cells/μL) produced a sensitivity of 80.0%, specificity of 75.0%, PPV of 88.9%, and NPV of 60.0%. based on this study Procalcitoninappeared to be a more accurate diagnostic of sepsis than eosinopenia, but eosinopenia is still a helpful tool for clinicians, and may also beused as a diagnostic marker of sepsis, because it is highly sensitive, moderately specific, easy to measure, rapid and inexpensive as well.

Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis

“…Neutrophil and lymphocyte are important components of the immune system, which initially fights off infection [24]. During sepsis, a strong adhesion between neutrophil and endothelium was made, causing the failure of neutrophil to migrate to the infection site [25].…”

Neutrophil-Lymphocyte Count Ratio in Bacterial Sepsis

“…Sepsis is also considered as one of the medical emergency problems, so it needs a quick, precise, and inexpensive diagnosis. [1][2] There were 50 out of 70 research samples that matched the inclusion criteria of bacterial sepsis. Among 70 samples of sepsis research, 46 samples (65%) were obtained with positive culture result, while 4 patients (5.7%) with negative culture result.…”

“…The increased number of neutrophils in sepsis patients is due to proinflammatory cytokines, such as IL-6, IL-1 and TNF- produced by macrophages. 1,9 On the other hand, the decreased number of lymphocytes in bacterial sepsis is caused by increased secretion of the hormone glucocorticoids that suppress the production of lymphocytes in the Lymphocytopenia gland. 10 Another theory suggests that the mechanisms responsible for the lymphocytopenia process in sepsis involve marginalitation and redistribution processes of lymphocytes in the lymphatic system as well as the acceleration of apoptotic process.…”

“…The ideal sepsis diagnostic markers must be: very specific and sensitive; easy to use; fast and cheap; and directly proportional to severity. 1 Culture is the gold standard, but takes a long time. As a result, it often causes a delay in diagnosis.…”

“…Consequently, a good and cheap sepsis marker that is easy to use is still needed. 1 Systemic Inflammation Response Syndrome (SIRS) is a collection of symptoms that can be triggered by ischemia, inflammatory processes, trauma, infection, or a combination of some of them, as a result, SIRS may not always be correlated with infection. 2 Infection is an inflammatory response due to microorganisms or microorganism invasion to tissues that are supposed to be sterile.…”