Sepsis is one of the common causes of morbidity and mortality in the ICU. Clinicians need to know and realize of good diagnosticmarkers to identify sepsis as early as possible. The role of eosinopenia as a marker of sepsis has recently been evaluated.The aim of thisstudy was to test the value of eosinopenia as a diagnostic marker of sepsis in comparison to Procalcitonin. A cross sectional study wasperformed in 61 adult patients with SIRS, and blood of all patients were cultured. Further examinations were done for comparing theeosinophil count with the Procalcitonin levels if the blood culture was positive or when there were clinical signs which supported for sepsis.In this study there were fourty two patients enrolled. Procalcitonin level yielded a sensitivity of 90.0%, specificity of 83.3%, a positivepredictive value (PPV) of 93.1% and a negative predictive value (NPV) of 76.9% at cut-off value of 2.75 ng/mL. The eosinophil (cut off ≤50 cells/μL) produced a sensitivity of 80.0%, specificity of 75.0%, PPV of 88.9%, and NPV of 60.0%. based on this study Procalcitoninappeared to be a more accurate diagnostic of sepsis than eosinopenia, but eosinopenia is still a helpful tool for clinicians, and may also beused as a diagnostic marker of sepsis, because it is highly sensitive, moderately specific, easy to measure, rapid and inexpensive as well.

Coronaviruses are a family of viruses that cause illness from the common cold to severe diseases such as Severe AcuteRespiratory Syndrome (SARS-CoV). In December 2019, forty new cases of pneumonia of unknown etiology have beenreported in Wuhan, China. The disease resembles Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and hasbeen subsequently named the 2019-novel Coronavirus Disease (COVID-19). The antibody test is a blood test that providesquantitative and qualitative detection of IgG and IgM antibodies against the SARS-CoV-2. Reported a male, 43-year oldsuffering from DHF, but the results of an IgG and IgM rapid test were COVID-19 reactive. Also, reviewed rapid tests forCOVID-19 and the results showed that only IgG was reactive. This explained that the patient already had SARS Cov-2antibodies but was not suffering from the disease. The rapid test COVID-19 IgM result was deemed to be a false positive.

Sepsis akibat infeksi bakteri merupakan masalah kegawatdaruratan medik yang serius sehingga memerlukan penanganan cepat dantepat. Saat ini C-RP (C- reactive protein) dan PCT (procalcitonin) sering digunakan sebagai petanda sepsis bakterial. Sepsis adalah infeksiyang disertai inflamasi sistemik. Respons fisiologis terhadap inflamasi sistemik adalah peningkatan jumlah neutrofil dan penurunanjumlah limfosit, sehingga gabungan perbandingan neutrofil dan limfosit Neutrophil Lymphocyte Count Ratio (NLCR)) dapat digunakansebagai petanda sepsis. Penelitian ini bertujuan untuk mengetahui kepekaan dan kekhasana dari uji NLCR di pasien sepsis akibatinfeksi bakteri. Terdapat 70 pasien SIRS dengan rentang usia 14–70 tahun di RS Mitra Keluarga Bekasi Timur dan RS FK - UKI Jakartamasa waktu bulan Juli–September 2015. Penelitian ini merupakan studi observasional komparatif dan potong lintang. Hasil penelitianmenunjukkan uji NLCR terhadap sepsis bakterial berdasarkan kurva ROC memiliki kepekaan 97,8% dan kekhasan 84,0% pada cutoff ≥6,4 (AUC: 0,94, nilai p<0,05). Neutrophil lymphocyte count ratio dapat diandalkan sebagai petanda sepsis bakterial dengan ujikepekaan dan kekhasan yang baik.