Eosinophilia in Wegener's Granulomatosis

Potter, Mark B.; Fincher, Roger Keith; Finger, David R.

doi:10.1378/chest.116.5.1480

Cited by 42 publications

(20 citation statements)

References 15 publications

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“…Till now only four cases of WG with peripheral eosinophilia (more than1,500/l) have been reported to date. [5][6][7][8] According to the Hammanrich criteria for CSS, a peripheralblood eosinophil count of more than 1,500/l is suggestiveof CSS. 5 However, the four previous cases and the presentpatient were considered as WG with eosinophilia in view ofthe involved organs and theexistence of PR3-ANCA, eventhough their peripheral blood eosinophil count was higherthanthatlevel.…”

Section: Discussionmentioning

confidence: 99%

Wegeners Granulomatosis with Peripheral Eosinophilia in a Young Adult Patient

et al. 2014

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Wegeners granulomatosis is a rare autoimmue disease with multi-system involvement that manifests as granulomatous vasculitic lesions, mainly involving the upper respiratory tract, lower respiratory tract and kidney. We present a case in a young adult male patient presenting with complaints of epistaxis, cough and hemoptysis who was diagnosed as Wegeners granulomatosiswith peripheral eosinophilia on the basis of chest x-ray and CT Chest and pathological confirmation by high level of serum cytoplasmic antineutrophil cytoplasmic antibody.DOI: http://dx.doi.org/10.3329/jom.v14i2.19689 J Medicine 2013, 14(2): 204-206

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Section: Discussionmentioning

confidence: 99%

Wegeners Granulomatosis with Peripheral Eosinophilia in a Young Adult Patient

et al. 2014

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“…Meist bereitet der Ausschluss einer 7 Wegener-Granulomatose (WG), mikroskopischen Polyangiitis (MPA) oder Panarteriitis nodosa (PAN) kein Problem. Die allergische Anamnese und die meist ausgeprägte Eosinophilie beim CSS sind klare Unterscheidungsmerkmale, wenn auch eine Eosinophilie bei WGPatienten selten einmal vorkommen kann [15]. Die Diagnose eines CSS wird heute meist mithilfe der ACR-Kriterien von 1990 nach Ausschluss anderer Differenzialdiagnosen gestellt 4 von 6 Kriterien müssen zur Klassifikation als CSS erfüllt sein.…”

Section: Epidemiologie äTiologie Und Pathogeneseunclassified

Das Churg-Strauss-Syndrom

Zwerina¹

2008

Z. Rheumatol.

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Churg-Strauss syndrome is a systemic ANCA-associated vasculitis arising almost exclusively in patients with a pre-existent asthma. Common clinical manifestations are marked blood eosinophilia, asthma, chronic sinusitis, cardiomyopathy, pulmonary infiltrates, gastrointestinal complaints and a multiplex neuropathy. The morphological substrate is an eosinophilic necrotizing vasculitis. Other eosinophilic disorders such as parasitic diseases, allergies and idiopathic hyper-eosinophilic syndrome have to be excluded. The mainstay of therapy is high-dose corticosteroids with the addition of cytotoxic drugs in patients with poor prognosis.

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“…Auf der anderen Seite gibt es auch Argumente für das Vorliegen eines Churg-Strauss-Syndroms, da neben einer mäßigen Bluteosinophilie auch eosinophile Gewebsinfiltrate vorlagen. In der Literatur sind aber auch Fälle von M. Wegener beschrieben, bei denen eine deutliche Eosinophilie bestand (17). Wie bereits beschrieben, kamen die Differentialdiagnosen einer Sarkoidose und einer HIV-Infektion aufgrund des klinischen Bildes und der serologischen Befunde nicht in Betracht.…”

Section: Diskussionunclassified