Eosinophilic dermatosis of hematologic malignancy: A retrospective cohort of 37 patients from an Italian center

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review

“…Eosinophilic dermatoses of HMs encompass a heterogeneous group of cutaneous eruptions that predominantly occur in patients with indolent lymphoproliferative disorders, mostly B-cell chronic lymphatic leukaemia [103]. The condition was first described by Weed in 1965, reporting on ten patients with B-cell chronic lymphatic leukaemia experiencing unusual delayed hypersensitivity reactions to mosquito bites [104].…”

“…Besides B-cell chronic lymphatic leukaemia, where EDHM is estimated to affect 6-8% of patients, and B-cell lymphoproliferative disorders, EDHM can also occur in association with other HMs, such as T-cell lymphomas, acute leukaemia, chronic myeloproliferative disorders and plasma cell dyscrasias [103,105,108,109]. The disease usually manifests months to years after the diagnosis of the HM; however, a minority of patients experienced the skin eruption up to 10 years prior to the haematological diagnosis [105,110].…”

Reply to ‘Comment on “Fatal occurrence of acquired haemophilia A in a patient with pemphigus vulgaris”’

“…In a previous work, we pointed out that the association between autoimmune bullous disease and HM may be overestimated because of a clinical and pathological overlap with eosinophilic dermatosis of haematological malignancies (EDHM) . Although this condition overlaps more often with BP, we recently observed a case of EDHM presenting with extensive intraepidermal detachment mimicking the acantholysis of PV (R. Maglie, unpublished data).…”

Hematologic-Related Malignancy-Induced Eosinophilic Dermatosis (He Remained): An eosinophilic dermatosis predominantly associated with chronic lymphocytic leukemia

“…To the Editor: I read with interest the enlightening research letter by Grandi et al 1 and the accompanying astute clinician's perspective by Heymann,2 which summarize many of the salient features of a paraneoplastic dermatosis that is characterized by recurrent episodes of pruritic erythematous lesions-ranging from papules and nodules to urticarial plaques and blisters-that show prominent dermal eosinophilia. 3,4 The world literature on eosinophilic dermatosis of hematologic malignancy (EDHM) was recently reviewed 5 ; to the best of my knowledge, 206 patients with this condition have been described (Table I).…”