Eosinophilic pustular folliculitis of infancy: A series of 15 cases and review of the literature

Hernández‐Martín, Ángela; Nuño-González, Almudena; Colmenero, Isabel; Torrelo, Antonio

doi:10.1016/j.jaad.2012.05.025

Cited by 56 publications

(93 citation statements)

References 34 publications

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“…The most commonly affected age group was between the third and fourth decade, which is consistent with previous results [12]. Although several cases of infants with EPF (also known as I-EPF) have been reported, no patient was aged <10 years in the present study [13,14,15]. Katoh et al [3] reviewed all published cases of EPF in Japan and showed that 4% were I-EPF, suggesting that I-EPF may include other diseases than EPF because of the lower incidence and the unusual clinical findings.…”

Section: Discussionsupporting

confidence: 92%

Clinical Epidemiology of Eosinophilic Pustular Folliculitis: Results from a Nationwide Survey in Japan

Yamamoto

Nomura²,

Kabashima³

2014

Dermatology

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Background: No epidemiological study has examined the clinical characteristics, including medication use, of patients with eosinophilic pustular folliculitis (EPF). Objective: To describe the clinical characteristics for EPF and to examine the factors associated with the effectiveness of oral indomethacin for EPF. Methods: A cross-sectional study was performed of patients with EPF who visited the dermatology departments of the 67 main teaching facilities in Japan. We documented the patient characteristics and examined factors associated with the effectiveness of oral indomethacin. Results: A total of 145 patients with EPF were enrolled; 62.8% were prescribed oral indomethacin. A multivariable analysis revealed that female patients were more likely to exhibit complete response to oral indomethacin after adjustment for confounders (adjusted proportion ratio = 1.93, p = 0.04). Conclusion: Oral indomethacin has been accepted as a first-line treatment in EPF. Our results suggest that there is a sex difference in the treatment response to oral indomethacin.

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Section: Discussionsupporting

confidence: 92%

Clinical Epidemiology of Eosinophilic Pustular Folliculitis: Results from a Nationwide Survey in Japan

Yamamoto

Nomura²,

Kabashima³

2014

Dermatology

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“…Lesions in infants usually exhibit secondary crusting . Infantile EPF is more common in Caucasian boys (male : female ratio: 8 : 1) and typically affects children aged 5–10 months . However, some neonatal cases have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Pruritus is common, but there are typically no associated systemic manifestations. Because peripheral blood eosinophilia appears at the beginning of flares in up to 70% of infants, the condition may be undetected in some children . Sometimes serum immunoglobulin E (IgE) may be elevated .…”

Section: Discussionmentioning

confidence: 99%

“…No infectious agent has ever been identified. A possible association between I‐EPF and atopy has been pointed out …”

Section: Discussionmentioning

confidence: 99%

“…Unlike the classical form, histologically I‐EPF does not display true folliculitis in all cases, but dense eosinophilic infiltrates may spread within the superficial and mid‐dermis, in a perifollicular, interfollicular, and/or periadnexal array . This is the reason why some authors prefer to use the term “eosinophilic pustulosis of infancy”, proposed by Taïeb .…”

Section: Discussionmentioning

confidence: 99%

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