Eosinophilic spongiosis: a localized bullous dermatosis unassociated with pemphigus

Kennedy, Cameron; Hodge, Leicester; Sanderson, K.V.

doi:10.1111/j.1365-2230.1978.tb01474.x

Cited by 4 publications

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References 6 publications

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“…Other variants of pemphigus, such as eosinophilic spongiosis, may be more difficult to identify since these cases may clinically resemble bullous pemphigoid or dermatitis herpetiformis. Immunopathologicaily the majority of cases of eosinophilic spongiosis can be shown to belong to the pemphigus group with intercellular epidermal direct IMF (Knight, Black & Delaney, 1976), although there are other cases who appear to be unrelated to pemphigus (Knight et al, 1976;Black 1977;Kennedy, Hodge & Sanderson, 1978). ' I 2.…”

Section: Imf Findings In the Bullous Disordersmentioning

confidence: 99%

The value of immunofluorescence techniques in the diagnosis of bullous disorders: a review

1983

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Immunofiuorescence (IMF) techniques are often of considerable help in the diagnosis of bullous disorders. It must be emphasized however, that they do not circumvent the need for routine skin histopathology. It is by considering the results of IMF and histopathology together that one is likely to avoid making diagnostic errors. As with routine skin histopathology, if the initial IMF findings are negative and the bullous disease is evolving or changing its clinical appearance, both histopathology and IMF tests should be repeated at serial intervals. As with any laboratory or other diagnostic investigation, clinical judgement is at all times paramount in deciding on the correct diagnosis. Methods /. Specimens(a) Serum samples. About 10 ml of blood without anticoagulant should be collected and the serum separated from the clotted blood as soon as possible. Such serum samples can be mailed without freezing. Clotted whole blood should never be mailed frozen as this induces massive haemolysis.(b) Skin biopsy specimens. As in diagnostic histopathology the site of biopsy is of crucial importance. In the bullous dermatoses it is preferable to take the erythematous peri-bullous margin of early vesicles or bullae to use for IMF (Fig. t). At the same time it is convenient to excise the whole bulla in an eleptical biopsy so that the bulla and the other edge can be placed in formalin for routine histopathological examination. In general in our experience, punch biopsy

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